YER145C / FTR1

High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER145C / FTR1

Click on Significant Values for Screen Details ID:SGTC_157|Compound:1348-1695|FD-Score:11.40|P-value:2.28E-28 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.13|P-value:3.62E-5 ID:SGTC_263|Compound:alizarin|FD-Score:4.68|P-value:3.43E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:-7.00|P-value:8.81E-12 ID:SGTC_428|Compound:3448-4153|FD-Score:3.92|P-value:8.17E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:4.07|P-value:4.56E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.28|P-value:8.03E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.70|P-value:1.92E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.35|P-value:6.52E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.49|P-value:8.23E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.14|P-value:3.52E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:4.34|P-value:1.54E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.44|P-value:4.76E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.32|P-value:1.60E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.26|P-value:8.66E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.31|P-value:7.40E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.44|P-value:4.77E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.89|P-value:9.50E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:5.06|P-value:5.99E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.24|P-value:9.42E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:5.60|P-value:3.76E-8 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.34|P-value:6.68E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-3.49|P-value:3.95E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.10|P-value:4.78E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:6.45|P-value:3.01E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.88|P-value:9.59E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.47|P-value:4.35E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.72|P-value:1.77E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.45|P-value:4.56E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_1611|Compound:st001856|FD-Score:5.37|P-value:1.24E-7 ID:SGTC_1624|Compound:st003710|FD-Score:-3.25|P-value:8.95E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.18|P-value:2.68E-12 ID:SGTC_1660|Compound:st012960|FD-Score:3.24|P-value:9.32E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.25|P-value:9.14E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.76|P-value:2.40E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.36|P-value:6.34E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.37|P-value:1.37E-5 ID:SGTC_2153|Compound:5569715|FD-Score:4.34|P-value:1.55E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.45|P-value:4.58E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.81|P-value:1.28E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_2275|Compound:7947463|FD-Score:9.09|P-value:1.30E-18 ID:SGTC_2291|Compound:7917025|FD-Score:12.20|P-value:3.42E-32 ID:SGTC_2389|Compound:9091542|FD-Score:4.46|P-value:9.33E-6 ID:SGTC_2396|Compound:5342950|FD-Score:3.45|P-value:4.63E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.59|P-value:1.22E-10 ID:SGTC_2444|Compound:5485484|FD-Score:3.95|P-value:7.29E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.69|P-value:3.39E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.56|P-value:3.13E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.54|P-value:6.47E-6 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.25|P-value:9.11E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.40|P-value:5.48E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.23|P-value:9.66E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.54|P-value:6.55E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.35|P-value:6.40E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.42|P-value:5.07E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:7.30|P-value:1.22E-12 ID:SGTC_2704|Compound:st078022|FD-Score:5.25|P-value:2.30E-7 ID:SGTC_2827|Compound:7993847|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.35|P-value:6.56E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.24|P-value:2.29E-5 ID:SGTC_3065|Compound:9113888|FD-Score:4.34|P-value:1.51E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.69|P-value:1.95E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.25|P-value:2.26E-7 ID:SGTC_3166|Compound:9102297|FD-Score:3.73|P-value:1.69E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.32|P-value:7.21E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.75|P-value:2.51E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:11.40|P-value:2.28E-28 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.13|P-value:3.62E-5 ID:SGTC_263|Compound:alizarin|FD-Score:4.68|P-value:3.43E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:-7.00|P-value:8.81E-12 ID:SGTC_428|Compound:3448-4153|FD-Score:3.92|P-value:8.17E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:4.07|P-value:4.56E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.28|P-value:8.03E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.70|P-value:1.92E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.35|P-value:6.52E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.49|P-value:8.23E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.14|P-value:3.52E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:4.34|P-value:1.54E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:3.44|P-value:4.76E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.32|P-value:1.60E-7 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.26|P-value:8.66E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.31|P-value:7.40E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.44|P-value:4.77E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.89|P-value:9.50E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:5.06|P-value:5.99E-7 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.24|P-value:9.42E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:5.60|P-value:3.76E-8 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.34|P-value:6.68E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-3.49|P-value:3.95E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.10|P-value:4.78E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:6.45|P-value:3.01E-10 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.88|P-value:9.59E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.47|P-value:4.35E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.72|P-value:1.77E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.45|P-value:4.56E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.62|P-value:2.58E-4 ID:SGTC_1611|Compound:st001856|FD-Score:5.37|P-value:1.24E-7 ID:SGTC_1624|Compound:st003710|FD-Score:-3.25|P-value:8.95E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.18|P-value:2.68E-12 ID:SGTC_1660|Compound:st012960|FD-Score:3.24|P-value:9.32E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.74|P-value:1.65E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.25|P-value:9.14E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.76|P-value:2.40E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.36|P-value:6.34E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.37|P-value:1.37E-5 ID:SGTC_2153|Compound:5569715|FD-Score:4.34|P-value:1.55E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.45|P-value:4.58E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.82|P-value:1.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.81|P-value:1.28E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.10|P-value:4.19E-5 ID:SGTC_2275|Compound:7947463|FD-Score:9.09|P-value:1.30E-18 ID:SGTC_2291|Compound:7917025|FD-Score:12.20|P-value:3.42E-32 ID:SGTC_2389|Compound:9091542|FD-Score:4.46|P-value:9.33E-6 ID:SGTC_2396|Compound:5342950|FD-Score:3.45|P-value:4.63E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.59|P-value:1.22E-10 ID:SGTC_2444|Compound:5485484|FD-Score:3.95|P-value:7.29E-5 ID:SGTC_2473|Compound:5854593|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.69|P-value:3.39E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.56|P-value:3.13E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.54|P-value:6.47E-6 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.25|P-value:9.11E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.40|P-value:5.48E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.23|P-value:9.66E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.54|P-value:6.55E-6 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.35|P-value:6.40E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.42|P-value:5.07E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:7.30|P-value:1.22E-12 ID:SGTC_2704|Compound:st078022|FD-Score:5.25|P-value:2.30E-7 ID:SGTC_2827|Compound:7993847|FD-Score:3.34|P-value:6.64E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.35|P-value:6.56E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.24|P-value:2.29E-5 ID:SGTC_3065|Compound:9113888|FD-Score:4.34|P-value:1.51E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-3.69|P-value:1.95E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.25|P-value:2.26E-7 ID:SGTC_3166|Compound:9102297|FD-Score:3.73|P-value:1.69E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.32|P-value:7.21E-4 ID:SGTC_3334|Compound:9142812|FD-Score:4.75|P-value:2.51E-6

Top fitness defect scores for YER145C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2291 7917025 12.20 104.3 µM 3.42E-32 iron homeostasis 3 9.89E-35
2 SGTC_157 1348-1695 11.40 65.8 µM 2.28E-28 iron homeostasis 10 1.38E-30
3 SGTC_2275 7947463 9.09 200.0 µM 1.30E-18 iron homeostasis 5 5.09E-20
4 SGTC_2633 5,7-dihydroxyisoflavone 7.30 100.0 µM 1.22E-12 3 1.49E-13
5 SGTC_1658 st012944 7.18 20.0 µM 2.68E-12 iron homeostasis 15 3.49E-13
6 SGTC_2418 pentamidine 6.59 31.7 µM 1.22E-10 mitochondrial processes 13 2.17E-11
7 SGTC_1174 0739-0097 6.45 51.1 µM 3.01E-10 redox potentiating 6 5.77E-11
8 SGTC_1141 3253-0389 5.60 52.6 µM 3.76E-8 3 1.07E-8
9 SGTC_1611 st001856 5.37 99.4 µM 1.24E-7 5 3.91E-8
10 SGTC_892 0929-0076 5.32 29.0 µM 1.60E-7 TRP & mitochondrial translation 10 5.12E-8
11 SGTC_3142 9086498 5.25 49.5 µM 2.26E-7 iron homeostasis 15 7.45E-8
12 SGTC_2704 st078022 5.25 71.1 µM 2.30E-7 7 7.60E-8
13 SGTC_1160 4092-0570 5.10 10.5 µM 4.78E-7 plasma membrane duress 19 1.68E-7
14 SGTC_1080 nisoldipine 5.06 24.4 µM 5.99E-7 TSC3-RPN4 9 2.14E-7
15 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 4.76 14.9 µM 2.40E-6 3 9.61E-7
16 SGTC_3334 9142812 4.75 21.9 µM 2.51E-6 15 1.01E-6
17 SGTC_2500 5-alpha-androstan-3,17-dione 4.69 61.4 µM 3.39E-6 26 1.39E-6
18 SGTC_263 alizarin 4.68 107.9 µM 3.43E-6 iron homeostasis 40 1.41E-6
19 SGTC_2516 gossypol 4.54 71.5 µM 6.47E-6 9 2.80E-6
20 SGTC_2597 laccaic acid a 4.54 100.0 µM 6.55E-6 21 2.84E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.451 1.11E-167 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.436 6.10E-156 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.374 3.36E-112 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.315 4.20E-78 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.292 4.99E-67 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.266 2.91E-55 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.251 2.96E-49 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.224 1.64E-39 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.167 2.68E-22 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.159 1.51E-20 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.159 2.35E-20 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.145 3.24E-17 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.143 8.28E-17 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.141 1.94E-16 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.136 3.04E-15 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane