YER147C / SCC4

Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER147C / SCC4

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-3.96|P-value:1.57E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.88|P-value:4.67E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.05|P-value:7.46E-11 ID:SGTC_341|Compound:1486-1430|FD-Score:4.22|P-value:6.70E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.52|P-value:7.26E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.42|P-value:9.87E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.50|P-value:7.75E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.18|P-value:7.72E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.68|P-value:4.30E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.03|P-value:1.32E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.50|P-value:7.39E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.37|P-value:3.86E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.78|P-value:3.10E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.71|P-value:3.93E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.85|P-value:2.51E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.78|P-value:3.14E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.47|P-value:8.35E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.91|P-value:1.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-4.43|P-value:2.84E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.58|P-value:1.59E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.50|P-value:2.15E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.88|P-value:2.26E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-4.90|P-value:4.28E-6 ID:SGTC_2939|Compound:9044578|FD-Score:3.81|P-value:2.78E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.26|P-value:6.59E-9 ID:SGTC_3065|Compound:9113888|FD-Score:-3.68|P-value:4.15E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.96|P-value:1.57E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-5.88|P-value:4.67E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.05|P-value:7.46E-11 ID:SGTC_341|Compound:1486-1430|FD-Score:4.22|P-value:6.70E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.52|P-value:7.26E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.42|P-value:9.87E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.50|P-value:7.75E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:4.18|P-value:7.72E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.68|P-value:4.30E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:4.03|P-value:1.32E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.50|P-value:7.39E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:4.37|P-value:3.86E-5 ID:SGTC_1757|Compound:st041620|FD-Score:3.78|P-value:3.10E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.71|P-value:3.93E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.85|P-value:2.51E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.78|P-value:3.14E-4 ID:SGTC_2280|Compound:7785178|FD-Score:3.47|P-value:8.35E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.91|P-value:1.92E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-4.43|P-value:2.84E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.58|P-value:1.59E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-4.50|P-value:2.15E-5 ID:SGTC_2818|Compound:7996756|FD-Score:3.88|P-value:2.26E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-4.90|P-value:4.28E-6 ID:SGTC_2939|Compound:9044578|FD-Score:3.81|P-value:2.78E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.26|P-value:6.59E-9 ID:SGTC_3065|Compound:9113888|FD-Score:-3.68|P-value:4.15E-4

Top fitness defect scores for YER147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1463 k081-0032 4.37 34.1 µM 3.86E-5 2 6.31E-6 0.81
2 SGTC_341 1486-1430 4.22 230.0 µM 6.70E-5 19 1.23E-5 0.12
3 SGTC_758 0868-0029 4.18 16.0 µM 7.72E-5 2 1.46E-5 1.04
4 SGTC_806 3966-4455 4.03 5.9 µM 1.32E-4 6 2.77E-5 0.12
5 SGTC_2818 7996756 3.88 13.0 µM 2.26E-4 7 5.32E-5 0.55
6 SGTC_2152 5568786 3.85 200.0 µM 2.51E-4 6 6.03E-5 0.41
7 SGTC_2939 9044578 3.81 71.4 µM 2.78E-4 7 6.83E-5 0.06
8 SGTC_1757 st041620 3.78 31.8 µM 3.10E-4 1 7.78E-5 0.32
9 SGTC_2279 7948423 3.78 32.9 µM 3.14E-4 8 7.90E-5 0.03
10 SGTC_2039 Aminomethylbenzodioxan 3.71 200.0 µM 3.93E-4 2 1.03E-4 0.21
11 SGTC_795 0685-0265 3.68 78.0 µM 4.30E-4 excess fatty acid 24 1.15E-4 0.04
12 SGTC_344 k064-0035 3.52 6.4 µM 7.26E-4 60S ribosome export 9 2.16E-4 0.10
13 SGTC_700 3453-2283 3.50 142.0 µM 7.75E-4 amide catabolism 10 2.34E-4 0.08
14 SGTC_2280 7785178 3.47 200.0 µM 8.35E-4 4 2.56E-4 0.15
15 SGTC_430 0958-0115 3.42 16.4 µM 9.87E-4 15 3.13E-4 0.01
16 SGTC_2760 etidronate 3.41 98.0 µM 0.00103 14 3.29E-4 0.03
17 SGTC_285 1486-1325 3.33 46.0 µM 0.00131 10 4.39E-4 0.04
18 SGTC_354 2783-3500 3.31 4.9 µM 0.00137 cell wall 42 4.63E-4 0.02
19 SGTC_358 0075-0058 3.30 9.4 µM 0.00142 17 4.85E-4 0.18
20 SGTC_91 0417-1751 3.26 58.4 µM 0.00161 Golgi 17 5.64E-4 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 6.66E-17 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.135 4.01E-15 YBR193C MED8 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.129 6.48E-14 YPL016W SWI1 het Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
0.120 4.03E-12 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.119 5.56E-12 YER018C SPC25 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.118 6.84E-12 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.117 8.87E-12 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.114 3.75E-11 YNL256W FOL1 het Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
0.113 5.53E-11 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.113 5.80E-11 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.108 3.00E-10 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.108 3.73E-10 YML063W RPS1B hom Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication
0.107 5.33E-10 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.105 1.09E-9 YKL042W SPC42 het Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
0.105 1.24E-9 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle