YER150W / SPI1

GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER150W / SPI1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.33|P-value:5.10E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.33|P-value:5.09E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.21|P-value:8.18E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.45|P-value:5.99E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.26|P-value:6.59E-4 ID:SGTC_417|Compound:st075190|FD-Score:-3.58|P-value:2.21E-4 ID:SGTC_462|Compound:ag-879|FD-Score:7.18|P-value:7.98E-13 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.26|P-value:6.66E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.43|P-value:3.61E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.40|P-value:4.11E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.32|P-value:5.34E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:5.40|P-value:5.25E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:4.07|P-value:3.10E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:5.21|P-value:1.46E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-5.01|P-value:4.28E-7 ID:SGTC_826|Compound:1683-5028|FD-Score:12.20|P-value:1.86E-33 ID:SGTC_828|Compound:2074-0507|FD-Score:8.32|P-value:1.31E-16 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.42|P-value:3.98E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.67|P-value:2.10E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.98|P-value:4.36E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.87|P-value:6.83E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.97|P-value:4.68E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.49|P-value:2.93E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.34|P-value:4.98E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.31|P-value:5.60E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.34|P-value:5.00E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.93|P-value:5.35E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.26|P-value:6.51E-4 ID:SGTC_1833|Compound:st055984|FD-Score:5.10|P-value:2.52E-7 ID:SGTC_1866|Compound:st057638|FD-Score:3.25|P-value:6.73E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.16|P-value:9.44E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.36|P-value:4.88E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.41|P-value:3.97E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.23|P-value:7.41E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.29|P-value:1.19E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.49|P-value:5.08E-6 ID:SGTC_2272|Compound:7805186|FD-Score:-3.30|P-value:5.94E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.14|P-value:9.77E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.48|P-value:3.11E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.95|P-value:4.97E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.43|P-value:3.58E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:8.91E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.63|P-value:1.76E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.86|P-value:7.13E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.72|P-value:1.27E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.98|P-value:4.67E-7 ID:SGTC_2692|Compound:st077426|FD-Score:3.87|P-value:6.96E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.20|P-value:8.36E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.23|P-value:7.66E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.29|P-value:5.94E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.10|P-value:2.65E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.30|P-value:1.12E-5 ID:SGTC_3303|Compound:9125618|FD-Score:6.27|P-value:3.27E-10 ID:SGTC_3352|Compound:9151559|FD-Score:4.15|P-value:2.16E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.33|P-value:5.10E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.33|P-value:5.09E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.21|P-value:8.18E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:4.45|P-value:5.99E-6 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.26|P-value:6.59E-4 ID:SGTC_417|Compound:st075190|FD-Score:-3.58|P-value:2.21E-4 ID:SGTC_462|Compound:ag-879|FD-Score:7.18|P-value:7.98E-13 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.26|P-value:6.66E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.43|P-value:3.61E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.40|P-value:4.11E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.32|P-value:5.34E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:5.40|P-value:5.25E-8 ID:SGTC_799|Compound:1310-0557|FD-Score:4.07|P-value:3.10E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:5.21|P-value:1.46E-7 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-5.01|P-value:4.28E-7 ID:SGTC_826|Compound:1683-5028|FD-Score:12.20|P-value:1.86E-33 ID:SGTC_828|Compound:2074-0507|FD-Score:8.32|P-value:1.31E-16 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.42|P-value:3.98E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.67|P-value:2.10E-6 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.98|P-value:4.36E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.87|P-value:6.83E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.97|P-value:4.68E-5 ID:SGTC_1523|Compound:st012844|FD-Score:3.49|P-value:2.93E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.34|P-value:4.98E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.31|P-value:5.60E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.34|P-value:5.00E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.93|P-value:5.35E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.26|P-value:6.51E-4 ID:SGTC_1833|Compound:st055984|FD-Score:5.10|P-value:2.52E-7 ID:SGTC_1866|Compound:st057638|FD-Score:3.25|P-value:6.73E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.16|P-value:9.44E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.36|P-value:4.88E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.41|P-value:3.97E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.23|P-value:7.41E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.29|P-value:1.19E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.49|P-value:5.08E-6 ID:SGTC_2272|Compound:7805186|FD-Score:-3.30|P-value:5.94E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.14|P-value:9.77E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.48|P-value:3.11E-4 ID:SGTC_2323|Compound:6148992|FD-Score:3.95|P-value:4.97E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.43|P-value:3.58E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:8.91E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.63|P-value:1.76E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.86|P-value:7.13E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.26|P-value:6.58E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.72|P-value:1.27E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.98|P-value:4.67E-7 ID:SGTC_2692|Compound:st077426|FD-Score:3.87|P-value:6.96E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.20|P-value:8.36E-4 ID:SGTC_2895|Compound:9054447|FD-Score:-3.23|P-value:7.66E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.29|P-value:5.94E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.10|P-value:2.65E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.30|P-value:1.12E-5 ID:SGTC_3303|Compound:9125618|FD-Score:6.27|P-value:3.27E-10 ID:SGTC_3352|Compound:9151559|FD-Score:4.15|P-value:2.16E-5

Top fitness defect scores for YER150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_826 1683-5028 12.20 118.0 µM 1.86E-33 1 1.74E-34
2 SGTC_828 2074-0507 8.32 139.0 µM 1.31E-16 RPP1 & pyrimidine depletion 2 4.38E-17
3 SGTC_462 ag-879 7.18 158.0 µM 7.98E-13 3 3.53E-13
4 SGTC_3303 9125618 6.27 40.6 µM 3.27E-10 12 1.76E-10
5 SGTC_798 1287-0182 5.40 476.0 µM 5.25E-8 8 3.31E-8
6 SGTC_815 1582-0027 5.21 36.9 µM 1.46E-7 6 9.49E-8
7 SGTC_1833 st055984 5.10 71.0 µM 2.52E-7 6 1.67E-7
8 SGTC_2639 lactacystin 4.98 53.0 µM 4.67E-7 14 3.16E-7
9 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.67 15.5 µM 2.10E-6 13 1.49E-6
10 SGTC_395 anisomycin 4.45 6.2 µM 5.99E-6 8 4.38E-6
11 SGTC_3217 9129673 4.30 49.5 µM 1.12E-5 27 8.36E-6
12 SGTC_2094 5332512 4.29 191.7 µM 1.19E-5 17 8.88E-6
13 SGTC_3352 9151559 4.15 45.6 µM 2.16E-5 10 1.64E-5
14 SGTC_3216 9129716 4.10 49.5 µM 2.65E-5 RPP1 & pyrimidine depletion 20 2.03E-5
15 SGTC_799 1310-0557 4.07 151.0 µM 3.10E-5 superoxide 19 2.39E-5
16 SGTC_1099 5-nonyloxytryptamine 3.98 2.9 µM 4.36E-5 18 3.39E-5
17 SGTC_1258 0671-0043 3.97 57.1 µM 4.68E-5 25 3.65E-5
18 SGTC_2323 6148992 3.95 148.3 µM 4.97E-5 34 3.89E-5
19 SGTC_1692 fluoroquinolonic acid 3.93 71.0 µM 5.35E-5 5 4.19E-5
20 SGTC_1112 tnp00069 3.87 1.2 µM 6.83E-5 24 5.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.99E-11 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.100 5.77E-9 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
0.099 8.15E-9 YOR137C SIA1 hom Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
0.091 1.44E-7 YOR288C MPD1 hom Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
0.088 2.88E-7 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.087 4.78E-7 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.079 4.42E-6 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.078 5.63E-6 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.078 6.23E-6 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.076 9.50E-6 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.076 1.07E-5 YKL011C CCE1 hom Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
0.076 1.07E-5 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
0.075 1.33E-5 YDR338C_p YDR338C_p hom Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
0.074 1.68E-5 YOR333C_d YOR333C_d hom Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.074 1.89E-5 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1