YER151C / UBP3

Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YER151C / UBP3

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-7.73|P-value:6.82E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:9.03|P-value:1.36E-15 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.84|P-value:1.64E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:4.84|P-value:1.13E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.51|P-value:7.15E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:4.48|P-value:4.37E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:6.68|P-value:2.55E-9 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.03|P-value:6.62E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.93|P-value:2.89E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.68|P-value:6.48E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.30|P-value:1.74E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.87|P-value:3.58E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.09|P-value:1.74E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.21|P-value:1.13E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.58|P-value:8.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.35|P-value:7.11E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.73|P-value:1.72E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:3.77|P-value:4.81E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:15.90|P-value:2.62E-44 ID:SGTC_676|Compound:falcarinol|FD-Score:6.37|P-value:1.24E-8 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.82|P-value:4.17E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.93|P-value:2.97E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.34|P-value:1.51E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.85|P-value:3.77E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.20|P-value:1.20E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.57|P-value:8.87E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.51|P-value:7.19E-7 ID:SGTC_999|Compound:4022-0066|FD-Score:4.81|P-value:1.26E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.31|P-value:1.73E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.17|P-value:1.32E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.59|P-value:8.47E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.85|P-value:3.82E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.78|P-value:4.67E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.70|P-value:6.10E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.37|P-value:6.48E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.28|P-value:1.89E-6 ID:SGTC_1523|Compound:st012844|FD-Score:4.37|P-value:6.68E-5 ID:SGTC_1547|Compound:harmine|FD-Score:9.76|P-value:6.70E-18 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.36|P-value:1.38E-6 ID:SGTC_1687|Compound:st020778|FD-Score:11.70|P-value:1.06E-24 ID:SGTC_1712|Compound:st032288|FD-Score:-3.57|P-value:8.87E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.14|P-value:3.51E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.60|P-value:8.06E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.52|P-value:6.93E-7 ID:SGTC_1876|Compound:myriocin|FD-Score:6.23|P-value:2.46E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.38|P-value:1.26E-6 ID:SGTC_1898|Compound:st060199|FD-Score:4.60|P-value:2.86E-5 ID:SGTC_2227|Compound:7312221|FD-Score:3.89|P-value:3.34E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.39|P-value:6.17E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.24|P-value:1.05E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.66|P-value:6.90E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.79|P-value:4.60E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.81|P-value:4.25E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.62|P-value:1.99E-17 ID:SGTC_2443|Compound:5493264|FD-Score:3.69|P-value:6.30E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.54|P-value:3.54E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.02|P-value:2.16E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.83|P-value:1.18E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.98|P-value:2.49E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.92|P-value:2.99E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.71|P-value:1.90E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.74|P-value:1.67E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.05|P-value:5.07E-6 ID:SGTC_2846|Compound:9008642|FD-Score:3.62|P-value:7.73E-4 ID:SGTC_2865|Compound:9030313|FD-Score:4.77|P-value:1.48E-5 ID:SGTC_2867|Compound:9039098|FD-Score:4.56|P-value:3.30E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.06|P-value:1.90E-4 ID:SGTC_2968|Compound:9090663|FD-Score:7.10|P-value:2.58E-10 ID:SGTC_2997|Compound:9067075|FD-Score:4.05|P-value:1.99E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.84|P-value:1.16E-5 ID:SGTC_3032|Compound:9089427|FD-Score:5.93|P-value:1.05E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.74|P-value:5.39E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.50|P-value:4.17E-5 ID:SGTC_3142|Compound:9086498|FD-Score:4.00|P-value:2.34E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.54|P-value:9.86E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.69|P-value:2.06E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-4.01|P-value:2.22E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.15|P-value:1.43E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-5.09|P-value:4.26E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-4.57|P-value:3.20E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.27|P-value:9.48E-5 ID:SGTC_65|Compound:0798-0905|FD-Score:-7.73|P-value:6.82E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:9.03|P-value:1.36E-15 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.84|P-value:1.64E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:4.84|P-value:1.13E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.51|P-value:7.15E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:4.48|P-value:4.37E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:6.68|P-value:2.55E-9 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.03|P-value:6.62E-8 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.93|P-value:2.89E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.68|P-value:6.48E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.30|P-value:1.74E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.87|P-value:3.58E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:4.09|P-value:1.74E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-4.21|P-value:1.13E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.58|P-value:8.79E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.35|P-value:7.11E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.73|P-value:1.72E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:3.77|P-value:4.81E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:15.90|P-value:2.62E-44 ID:SGTC_676|Compound:falcarinol|FD-Score:6.37|P-value:1.24E-8 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.82|P-value:4.17E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.93|P-value:2.97E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.34|P-value:1.51E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:4.15|P-value:1.42E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:3.85|P-value:3.77E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.20|P-value:1.20E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.57|P-value:8.87E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.51|P-value:7.19E-7 ID:SGTC_999|Compound:4022-0066|FD-Score:4.81|P-value:1.26E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:5.31|P-value:1.73E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.17|P-value:1.32E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.59|P-value:8.47E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.85|P-value:3.82E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.78|P-value:4.67E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.70|P-value:6.10E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.37|P-value:6.48E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.28|P-value:1.89E-6 ID:SGTC_1523|Compound:st012844|FD-Score:4.37|P-value:6.68E-5 ID:SGTC_1547|Compound:harmine|FD-Score:9.76|P-value:6.70E-18 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.36|P-value:1.38E-6 ID:SGTC_1687|Compound:st020778|FD-Score:11.70|P-value:1.06E-24 ID:SGTC_1712|Compound:st032288|FD-Score:-3.57|P-value:8.87E-4 ID:SGTC_1743|Compound:st037606|FD-Score:5.14|P-value:3.51E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.60|P-value:8.06E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:5.52|P-value:6.93E-7 ID:SGTC_1876|Compound:myriocin|FD-Score:6.23|P-value:2.46E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.38|P-value:1.26E-6 ID:SGTC_1898|Compound:st060199|FD-Score:4.60|P-value:2.86E-5 ID:SGTC_2227|Compound:7312221|FD-Score:3.89|P-value:3.34E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.39|P-value:6.17E-5 ID:SGTC_2242|Compound:6630449|FD-Score:4.24|P-value:1.05E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.66|P-value:6.90E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.79|P-value:4.60E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.81|P-value:4.25E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.62|P-value:1.99E-17 ID:SGTC_2443|Compound:5493264|FD-Score:3.69|P-value:6.30E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.54|P-value:3.54E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.02|P-value:2.16E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.83|P-value:1.18E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.98|P-value:2.49E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.92|P-value:2.99E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.71|P-value:1.90E-5 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.74|P-value:1.67E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.05|P-value:5.07E-6 ID:SGTC_2846|Compound:9008642|FD-Score:3.62|P-value:7.73E-4 ID:SGTC_2865|Compound:9030313|FD-Score:4.77|P-value:1.48E-5 ID:SGTC_2867|Compound:9039098|FD-Score:4.56|P-value:3.30E-5 ID:SGTC_2962|Compound:9082311|FD-Score:4.06|P-value:1.90E-4 ID:SGTC_2968|Compound:9090663|FD-Score:7.10|P-value:2.58E-10 ID:SGTC_2997|Compound:9067075|FD-Score:4.05|P-value:1.99E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.84|P-value:1.16E-5 ID:SGTC_3032|Compound:9089427|FD-Score:5.93|P-value:1.05E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.74|P-value:5.39E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.50|P-value:4.17E-5 ID:SGTC_3142|Compound:9086498|FD-Score:4.00|P-value:2.34E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.54|P-value:9.86E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.69|P-value:2.06E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-4.01|P-value:2.22E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.15|P-value:1.43E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-5.09|P-value:4.26E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-4.57|P-value:3.20E-5 ID:SGTC_3299|Compound:9121982|FD-Score:4.27|P-value:9.48E-5

Top fitness defect scores for YER151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_592 k241-0073 15.90 46.5 µM 2.62E-44 1 3.07E-57
2 SGTC_1687 st020778 11.70 55.4 µM 1.06E-24 39 1.14E-31
3 SGTC_1547 harmine 9.76 94.2 µM 6.70E-18 ergosterol biosynthesis 7 8.30E-23
4 SGTC_2322 7413319 9.62 38.2 µM 1.99E-17 ERAD & cell cycle 20 3.43E-22
5 SGTC_70 0141-0289 9.03 43.3 µM 1.36E-15 mitochondrial stress 25 8.38E-20
6 SGTC_2968 9090663 7.10 33.4 µM 2.58E-10 3 6.13E-13
7 SGTC_157 1348-1695 6.68 65.8 µM 2.55E-9 iron homeostasis 17 1.20E-11
8 SGTC_676 falcarinol 6.37 140.0 µM 1.24E-8 11 9.36E-11
9 SGTC_1876 myriocin 6.23 605.0 nM 2.46E-8 14 2.28E-10
10 SGTC_255 tunicamycin 6.03 200.5 nM 6.62E-8 unfolded protein response 34 8.22E-10
11 SGTC_3032 9089427 5.93 49.5 µM 1.05E-7 60S ribosome export 2 1.50E-9
12 SGTC_1789 tunicamycin 5.52 25.0 nM 6.93E-7 unfolded protein response 22 1.73E-8
13 SGTC_119 0121-0043 5.51 24.8 µM 7.15E-7 mitochondrial stress 33 1.80E-8
14 SGTC_957 1187-1561 5.51 14.1 µM 7.19E-7 4 1.81E-8
15 SGTC_1877 wortmannin 5.38 25.0 µM 1.26E-6 56 3.73E-8
16 SGTC_1680 diphenhydramine 5.36 100.0 µM 1.38E-6 NEO1 10 4.19E-8
17 SGTC_800 3448-7362 5.34 155.0 µM 1.51E-6 translation 74 4.73E-8
18 SGTC_1013 4112-3890 5.31 241.0 µM 1.73E-6 TSC3-RPN4 13 5.63E-8
19 SGTC_1465 k213-0056 5.28 144.0 µM 1.89E-6 DNA intercalators 7 6.33E-8
20 SGTC_1743 st037606 5.14 46.4 µM 3.51E-6 8 1.41E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.324 8.99E-83 YNR051C BRE5 hom Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
0.203 2.16E-32 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.199 2.67E-31 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.194 8.95E-30 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.186 1.75E-27 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.184 6.89E-27 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.182 2.50E-26 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.181 4.08E-26 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.169 6.37E-23 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.167 2.94E-22 YKR001C VPS1 hom Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
0.165 5.80E-22 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.164 9.61E-22 YGL025C PGD1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
0.162 4.11E-21 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
0.157 5.63E-20 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.154 2.36E-19 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments