YER153C / PET122

Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YER153C / PET122

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.36|P-value:2.11E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.78|P-value:3.45E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.08|P-value:6.26E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.02|P-value:7.59E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.02|P-value:8.83E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.93|P-value:1.89E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:9.15|P-value:8.39E-22 ID:SGTC_154|Compound:3389-1638|FD-Score:3.72|P-value:5.76E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.43|P-value:1.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.18|P-value:4.83E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.04|P-value:1.18E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.48|P-value:1.53E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.29|P-value:3.24E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.07|P-value:7.19E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.59|P-value:9.88E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.04|P-value:8.21E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.85|P-value:2.35E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.19|P-value:4.16E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.44|P-value:8.01E-9 ID:SGTC_946|Compound:3434-1334|FD-Score:3.58|P-value:1.03E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.26|P-value:3.56E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.42|P-value:1.94E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.59|P-value:9.69E-5 ID:SGTC_1881|Compound:5652484|FD-Score:-3.32|P-value:2.52E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.33|P-value:2.33E-11 ID:SGTC_2003|Compound:4023581|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.95|P-value:1.34E-7 ID:SGTC_2101|Compound:5377231|FD-Score:3.69|P-value:6.33E-5 ID:SGTC_2373|Compound:9071805|FD-Score:-4.05|P-value:1.11E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-2.98|P-value:8.90E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.38|P-value:2.27E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.03|P-value:8.52E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.67|P-value:6.95E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-8.89|P-value:7.44E-21 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.59|P-value:9.43E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.20|P-value:4.55E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.88|P-value:2.80E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.03|P-value:8.36E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.60|P-value:8.23E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.50|P-value:1.40E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.10|P-value:6.48E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.63|P-value:7.05E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.36|P-value:2.11E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.78|P-value:3.45E-7 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.08|P-value:6.26E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.02|P-value:7.59E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.02|P-value:8.83E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.93|P-value:1.89E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:9.15|P-value:8.39E-22 ID:SGTC_154|Compound:3389-1638|FD-Score:3.72|P-value:5.76E-5 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.43|P-value:1.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.46|P-value:1.63E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.18|P-value:4.83E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.04|P-value:1.18E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:3.48|P-value:1.53E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.29|P-value:3.24E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.07|P-value:7.19E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.59|P-value:9.88E-5 ID:SGTC_880|Compound:0833-0487|FD-Score:3.04|P-value:8.21E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.85|P-value:2.35E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:3.27|P-value:3.47E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.19|P-value:4.16E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.44|P-value:8.01E-9 ID:SGTC_946|Compound:3434-1334|FD-Score:3.58|P-value:1.03E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.26|P-value:3.56E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.42|P-value:1.94E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.59|P-value:9.69E-5 ID:SGTC_1881|Compound:5652484|FD-Score:-3.32|P-value:2.52E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.33|P-value:2.33E-11 ID:SGTC_2003|Compound:4023581|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_2012|Compound:4023501|FD-Score:4.95|P-value:1.34E-7 ID:SGTC_2101|Compound:5377231|FD-Score:3.69|P-value:6.33E-5 ID:SGTC_2373|Compound:9071805|FD-Score:-4.05|P-value:1.11E-5 ID:SGTC_2381|Compound:9035592|FD-Score:-2.98|P-value:8.90E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.38|P-value:2.27E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.03|P-value:8.52E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.67|P-value:6.95E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-8.89|P-value:7.44E-21 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.59|P-value:9.43E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.20|P-value:4.55E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.88|P-value:2.80E-5 ID:SGTC_2786|Compound:7743617|FD-Score:3.03|P-value:8.36E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.60|P-value:8.23E-5 ID:SGTC_2932|Compound:9016711|FD-Score:3.50|P-value:1.40E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.10|P-value:6.48E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-3.63|P-value:7.05E-5

Top fitness defect scores for YER153C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 9.15 6.9 µM 8.39E-22 46 2.85E-20
2 SGTC_1921 5740136 6.33 50.0 µM 2.33E-11 TRP & mitochondrial translation 14 1.23E-10
3 SGTC_939 1165-0479 5.44 45.3 µM 8.01E-9 4 2.73E-8
4 SGTC_2012 4023501 4.95 200.0 µM 1.34E-7 13 3.68E-7
5 SGTC_907 3448-6986 4.85 75.5 µM 2.35E-7 8 6.19E-7
6 SGTC_46 0329-0187a 4.78 2.2 µM 3.45E-7 46 8.85E-7
7 SGTC_2634 4'-methoxyflavone 4.59 100.0 µM 9.43E-7 20 2.25E-6
8 SGTC_2721 ifenprodil 3.88 61.4 µM 2.80E-5 plasma membrane duress 20 5.19E-5
9 SGTC_154 3389-1638 3.72 511.1 µM 5.76E-5 31 1.01E-4
10 SGTC_2101 5377231 3.69 179.2 µM 6.33E-5 11 1.11E-4
11 SGTC_2563 tomatine 3.67 8.5 µM 6.95E-5 63 1.21E-4
12 SGTC_1132 3456-3614 3.59 2.5 µM 9.69E-5 tubulin folding & SWR complex 71 1.64E-4
13 SGTC_684 1140-0066 3.59 328.0 µM 9.88E-5 Golgi 41 1.67E-4
14 SGTC_946 3434-1334 3.58 87.4 µM 1.03E-4 43 1.74E-4
15 SGTC_960 1222-0186 3.55 7.7 µM 1.16E-4 44 1.94E-4
16 SGTC_2932 9016711 3.50 44.5 µM 1.40E-4 62 2.32E-4
17 SGTC_386 1509-0011 3.48 3.1 µM 1.53E-4 167 2.51E-4
18 SGTC_236 1509-0011 3.46 5.3 µM 1.63E-4 420 2.66E-4
19 SGTC_886 0866-0150 3.43 153.0 µM 1.86E-4 36 3.01E-4
20 SGTC_1023 4482-3888 3.42 16.0 µM 1.94E-4 TSC3-RPN4 33 3.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.292 7.32E-67 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.286 4.70E-64 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.282 1.35E-62 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.269 1.39E-56 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.260 6.50E-53 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.255 5.05E-51 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.245 6.41E-47 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.243 3.28E-46 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.240 3.07E-45 YHL004W MRP4 hom Mitochondrial ribosomal protein of the small subunit
0.237 5.84E-44 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.232 2.78E-42 YMR256C COX7 hom Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.231 9.92E-42 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.224 2.96E-39 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.219 1.24E-37 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.216 6.74E-37 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase