YER154W / OXA1

Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals

Zygosity: Homozygous strain
fixedexpanded
Profile for YER154W / OXA1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:6.08|P-value:1.16E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.44|P-value:2.26E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.72|P-value:3.15E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.01|P-value:1.16E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.52|P-value:6.06E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.60|P-value:1.19E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.65|P-value:1.06E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:12.10|P-value:5.45E-29 ID:SGTC_236|Compound:1509-0011|FD-Score:7.24|P-value:1.46E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.65|P-value:3.75E-19 ID:SGTC_310|Compound:1273-0058|FD-Score:6.71|P-value:3.44E-10 ID:SGTC_383|Compound:2324-0395|FD-Score:3.67|P-value:3.73E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.95|P-value:1.41E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.26|P-value:4.68E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-3.83|P-value:2.21E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.30|P-value:3.84E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.52|P-value:5.98E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.26|P-value:6.62E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:4.11|P-value:7.92E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.58|P-value:5.06E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.91|P-value:3.17E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.37|P-value:9.90E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.80|P-value:5.19E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:3.76|P-value:2.78E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.43|P-value:8.07E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.44|P-value:7.81E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.99|P-value:1.25E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.94|P-value:1.44E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.98|P-value:1.25E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.92|P-value:1.58E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.65|P-value:3.91E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.38|P-value:2.82E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.38|P-value:3.87E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.47|P-value:7.04E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.47|P-value:7.22E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.36|P-value:9.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.18|P-value:6.21E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.74|P-value:6.63E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.10|P-value:8.23E-5 ID:SGTC_1908|Compound:st060353|FD-Score:-3.53|P-value:6.00E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.32|P-value:3.60E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.36|P-value:9.97E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.42|P-value:8.25E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.57|P-value:5.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.09|P-value:1.46E-6 ID:SGTC_2258|Compound:7960471|FD-Score:3.53|P-value:5.88E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.54|P-value:5.68E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.48|P-value:1.95E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.13|P-value:7.46E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-6.46|P-value:1.52E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-6.68|P-value:4.28E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:7.31|P-value:9.48E-12 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.70|P-value:3.32E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:5.51|P-value:2.08E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.65|P-value:9.80E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:7.86|P-value:2.50E-13 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.44|P-value:2.30E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.07|P-value:9.17E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:5.50|P-value:2.13E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-4.20|P-value:5.84E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.48|P-value:1.92E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.93|P-value:3.03E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.36|P-value:3.10E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.52|P-value:6.20E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.54|P-value:1.77E-7 ID:SGTC_2806|Compound:7952793|FD-Score:10.60|P-value:7.37E-23 ID:SGTC_2812|Compound:7970281|FD-Score:4.28|P-value:4.21E-5 ID:SGTC_2813|Compound:7971799|FD-Score:4.54|P-value:1.51E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-4.86|P-value:4.03E-6 ID:SGTC_2853|Compound:9015042|FD-Score:3.93|P-value:1.53E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.29|P-value:5.85E-7 ID:SGTC_2933|Compound:9026794|FD-Score:4.85|P-value:4.23E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.95|P-value:1.40E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.82|P-value:2.25E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.72|P-value:3.14E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.92|P-value:1.58E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.49|P-value:6.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.62|P-value:4.34E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.39|P-value:2.80E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:6.08|P-value:1.16E-8 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.44|P-value:2.26E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.72|P-value:3.15E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.01|P-value:1.16E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.52|P-value:6.06E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.60|P-value:1.19E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.65|P-value:1.06E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:12.10|P-value:5.45E-29 ID:SGTC_236|Compound:1509-0011|FD-Score:7.24|P-value:1.46E-11 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.65|P-value:3.75E-19 ID:SGTC_310|Compound:1273-0058|FD-Score:6.71|P-value:3.44E-10 ID:SGTC_383|Compound:2324-0395|FD-Score:3.67|P-value:3.73E-4 ID:SGTC_433|Compound:pimozide|FD-Score:3.95|P-value:1.41E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.26|P-value:4.68E-5 ID:SGTC_470|Compound:aa-861|FD-Score:-3.83|P-value:2.21E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.30|P-value:3.84E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.52|P-value:5.98E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.26|P-value:6.62E-7 ID:SGTC_630|Compound:4356-0227|FD-Score:4.11|P-value:7.92E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.58|P-value:5.06E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.91|P-value:3.17E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.37|P-value:9.90E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.80|P-value:5.19E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:3.76|P-value:2.78E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.91|P-value:1.65E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.43|P-value:8.07E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.44|P-value:7.81E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.99|P-value:1.25E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.94|P-value:1.44E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.98|P-value:1.25E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.92|P-value:1.58E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.65|P-value:3.91E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.38|P-value:2.82E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.38|P-value:3.87E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.47|P-value:7.04E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.47|P-value:7.22E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.36|P-value:9.94E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-4.18|P-value:6.21E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.74|P-value:6.63E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.10|P-value:8.23E-5 ID:SGTC_1908|Compound:st060353|FD-Score:-3.53|P-value:6.00E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.32|P-value:3.60E-5 ID:SGTC_1954|Compound:st077032|FD-Score:3.36|P-value:9.97E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.42|P-value:8.25E-4 ID:SGTC_2187|Compound:6125751|FD-Score:3.57|P-value:5.22E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.09|P-value:1.46E-6 ID:SGTC_2258|Compound:7960471|FD-Score:3.53|P-value:5.88E-4 ID:SGTC_2373|Compound:9071805|FD-Score:3.54|P-value:5.68E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.48|P-value:1.95E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-4.13|P-value:7.46E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-6.46|P-value:1.52E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-6.68|P-value:4.28E-10 ID:SGTC_2418|Compound:pentamidine|FD-Score:7.31|P-value:9.48E-12 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.70|P-value:3.32E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:5.51|P-value:2.08E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:4.65|P-value:9.80E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:7.86|P-value:2.50E-13 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.44|P-value:2.30E-5 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:4.07|P-value:9.17E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:5.50|P-value:2.13E-7 ID:SGTC_2720|Compound:fluspirilene|FD-Score:-4.20|P-value:5.84E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:4.48|P-value:1.92E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.93|P-value:3.03E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.36|P-value:3.10E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.52|P-value:6.20E-4 ID:SGTC_2804|Compound:7954240|FD-Score:5.54|P-value:1.77E-7 ID:SGTC_2806|Compound:7952793|FD-Score:10.60|P-value:7.37E-23 ID:SGTC_2812|Compound:7970281|FD-Score:4.28|P-value:4.21E-5 ID:SGTC_2813|Compound:7971799|FD-Score:4.54|P-value:1.51E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-4.86|P-value:4.03E-6 ID:SGTC_2853|Compound:9015042|FD-Score:3.93|P-value:1.53E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.29|P-value:5.85E-7 ID:SGTC_2933|Compound:9026794|FD-Score:4.85|P-value:4.23E-6 ID:SGTC_2965|Compound:9082772|FD-Score:3.95|P-value:1.40E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.82|P-value:2.25E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.72|P-value:3.14E-4 ID:SGTC_2998|Compound:9066762|FD-Score:3.92|P-value:1.58E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.49|P-value:6.79E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.61|P-value:4.53E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.62|P-value:4.34E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.39|P-value:2.80E-5

Top fitness defect scores for YER154W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 12.10 2.7 µM 5.45E-29 mitochondrial stress 25 5.56E-34
2 SGTC_2806 7952793 10.60 58.4 µM 7.37E-23 2 1.00E-26
3 SGTC_275 trichlorophene 9.65 5.7 µM 3.75E-19 mitochondrial stress 50 2.43E-22
4 SGTC_2611 pyromycin 7.86 23.9 µM 2.50E-13 3 1.87E-15
5 SGTC_2418 pentamidine 7.31 31.7 µM 9.48E-12 mitochondrial processes 8 1.37E-13
6 SGTC_236 1509-0011 7.24 5.3 µM 1.46E-11 264 2.27E-13
7 SGTC_310 1273-0058 6.71 1.1 µM 3.44E-10 mitochondrial stress 125 9.51E-12
8 SGTC_19 0279-0214 6.08 38.4 µM 1.16E-8 TRP & mitochondrial translation 10 6.03E-10
9 SGTC_2804 7954240 5.54 19.5 µM 1.77E-7 6 1.50E-8
10 SGTC_2595 hexamethylquercetagetin 5.51 100.0 µM 2.08E-7 8 1.81E-8
11 SGTC_2718 lomofungin 5.50 53.0 µM 2.13E-7 mitochondrial processes 1 1.87E-8
12 SGTC_1369 1866-0067 5.38 208.0 µM 3.87E-7 RPP1 & pyrimidine depletion 15 3.76E-8
13 SGTC_2924 9010168 5.29 62.8 µM 5.85E-7 cell wall signaling 12 6.13E-8
14 SGTC_625 k213-0058 5.26 121.0 µM 6.62E-7 translation 51 7.10E-8
15 SGTC_2250 alverine citrate 5.09 130.0 µM 1.46E-6 92 1.80E-7
16 SGTC_686 1319-0111 4.91 510.0 µM 3.17E-6 60S ribosome export 12 4.49E-7
17 SGTC_2933 9026794 4.85 32.5 µM 4.23E-6 6 6.31E-7
18 SGTC_767 0929-0023 4.80 86.0 µM 5.19E-6 TRP & mitochondrial translation 42 8.02E-7
19 SGTC_2610 ononetin 4.65 44.2 µM 9.80E-6 22 1.69E-6
20 SGTC_116 0155-0182 4.60 31.8 µM 1.19E-5 mitochondrial response to ROS 50 2.12E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.373 5.23E-111 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.362 1.36E-104 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.357 2.51E-101 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.350 1.75E-97 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.349 1.44E-96 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.343 4.77E-93 YDR065W RRG1 hom Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.337 1.55E-89 YHR147C MRPL6 hom Mitochondrial ribosomal protein of the large subunit
0.335 1.42E-88 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.333 1.31E-87 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.332 6.65E-87 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.331 3.17E-86 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.330 2.14E-85 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.328 1.11E-84 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.322 9.40E-82 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.321 4.49E-81 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron