YER155C / BEM2

Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence

Zygosity: Homozygous strain
fixedexpanded
Profile for YER155C / BEM2

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.27|P-value:1.39E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.51|P-value:2.35E-8 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.39|P-value:4.50E-8 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.86|P-value:7.61E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.26|P-value:6.86E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.80|P-value:9.65E-5 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.14|P-value:8.95E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.17|P-value:9.46E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.21|P-value:8.22E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.29|P-value:6.30E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.29|P-value:6.21E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.21|P-value:8.38E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.91|P-value:6.16E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:4.02|P-value:3.91E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.64|P-value:2.60E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.44|P-value:3.73E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.16|P-value:9.68E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.76|P-value:1.47E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.90|P-value:6.35E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.37|P-value:8.98E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.88|P-value:5.81E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.61|P-value:2.01E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.20|P-value:8.65E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.20|P-value:8.43E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.59|P-value:1.82E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.26|P-value:1.41E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-5.17|P-value:1.47E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.53|P-value:4.25E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.91|P-value:6.23E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.82|P-value:8.93E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.89|P-value:6.86E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.18|P-value:9.20E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.00|P-value:4.58E-7 ID:SGTC_2953|Compound:9074162|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.90|P-value:6.38E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.97|P-value:3.99E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.26|P-value:5.97E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.96|P-value:5.08E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.67|P-value:1.61E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.72|P-value:1.31E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.33|P-value:5.47E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.48|P-value:2.71E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.95|P-value:5.69E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.31|P-value:5.78E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.59|P-value:1.81E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.94|P-value:5.91E-7 ID:SGTC_39|Compound:0986-0283|FD-Score:4.27|P-value:1.39E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.51|P-value:2.35E-8 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.39|P-value:4.50E-8 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.86|P-value:7.61E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:3.26|P-value:6.86E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.80|P-value:9.65E-5 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.14|P-value:8.95E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.17|P-value:9.46E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.21|P-value:8.22E-4 ID:SGTC_500|Compound:h-89|FD-Score:3.29|P-value:6.30E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.29|P-value:6.21E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.21|P-value:8.38E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.91|P-value:6.16E-5 ID:SGTC_941|Compound:3237-0776|FD-Score:4.02|P-value:3.91E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.64|P-value:2.60E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:3.44|P-value:3.73E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.16|P-value:9.68E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.76|P-value:1.47E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.90|P-value:6.35E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.37|P-value:8.98E-6 ID:SGTC_1496|Compound:4469-0713|FD-Score:-3.88|P-value:5.81E-5 ID:SGTC_1722|Compound:st034304|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.61|P-value:2.01E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.20|P-value:8.65E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.20|P-value:8.43E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.59|P-value:1.82E-4 ID:SGTC_2453|Compound:5731132|FD-Score:4.26|P-value:1.41E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-5.17|P-value:1.47E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.53|P-value:4.25E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.91|P-value:6.23E-5 ID:SGTC_2784|Compound:7567673|FD-Score:3.82|P-value:8.93E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.89|P-value:6.86E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.18|P-value:9.20E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.00|P-value:4.58E-7 ID:SGTC_2953|Compound:9074162|FD-Score:3.36|P-value:4.87E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.90|P-value:6.38E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-3.97|P-value:3.99E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-3.26|P-value:5.97E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.96|P-value:5.08E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.67|P-value:1.61E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.72|P-value:1.31E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.33|P-value:5.47E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.48|P-value:2.71E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.95|P-value:5.69E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.31|P-value:5.78E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.59|P-value:1.81E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.94|P-value:5.91E-7

Top fitness defect scores for YER155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2873 9040596 5.00 71.4 µM 4.58E-7 23 2.94E-7
2 SGTC_3197 9113331 4.95 49.5 µM 5.69E-7 17 3.68E-7
3 SGTC_3234 9132280 4.94 49.5 µM 5.91E-7 6 3.82E-7
4 SGTC_1418 3966-3099 4.76 2.4 µM 1.47E-6 10 9.75E-7
5 SGTC_974 1326-0144 4.64 138.0 µM 2.60E-6 ERG2 23 1.76E-6
6 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.53 100.0 µM 4.25E-6 23 2.92E-6
7 SGTC_1424 4048-1941 4.37 275.0 µM 8.98E-6 17 6.29E-6
8 SGTC_39 0986-0283 4.27 58.4 µM 1.39E-5 calcium & mitochondrial duress 29 9.84E-6
9 SGTC_2453 5731132 4.26 22.2 µM 1.41E-5 14 1.00E-5
10 SGTC_941 3237-0776 4.02 460.0 µM 3.91E-5 14 2.86E-5
11 SGTC_2968 9090663 3.96 33.4 µM 5.08E-5 29 3.75E-5
12 SGTC_761 k216-0224 3.91 480.0 µM 6.16E-5 19 4.57E-5
13 SGTC_2754 granisetron 3.91 64.0 µM 6.23E-5 31 4.63E-5
14 SGTC_1422 4031-0024 3.90 15.5 µM 6.35E-5 iron homeostasis 19 4.72E-5
15 SGTC_2963 9082507 3.90 9.0 µM 6.38E-5 27 4.75E-5
16 SGTC_2828 7998861 3.89 71.4 µM 6.86E-5 17 5.11E-5
17 SGTC_45 0kpi-0036 3.86 14.9 µM 7.61E-5 excess fatty acid 29 5.69E-5
18 SGTC_2784 7567673 3.82 72.7 µM 8.93E-5 iron homeostasis 32 6.71E-5
19 SGTC_97 0535-0701 3.80 19.1 µM 9.65E-5 60S ribosome export 18 7.27E-5
20 SGTC_3124 9127567 3.72 49.5 µM 1.31E-4 DNA damage response 20 9.96E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 9.01E-9 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.092 9.69E-8 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.089 2.34E-7 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.083 1.54E-6 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.083 1.67E-6 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.082 1.98E-6 YML058W-A HUG1 hom Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress
0.078 6.65E-6 YGL080W FMP37 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
0.077 8.70E-6 YAL021C CCR4 hom Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
0.076 9.63E-6 YPL253C VIK1 hom Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
0.073 2.56E-5 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.072 2.68E-5 YOR368W RAD17 hom Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
0.071 3.61E-5 YGL137W SEC27 het Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
0.071 3.76E-5 YJL186W MNN5 hom Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.071 3.95E-5 YBR015C MNN2 hom Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
0.070 4.63E-5 YCL029C BIK1 hom Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170