YER156C_p

Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1

Zygosity: Homozygous strain
fixedexpanded
Profile for YER156C / YER156C

Click on Significant Values for Screen Details ID:SGTC_121|Compound:0557-0495|FD-Score:-3.80|P-value:1.38E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.22|P-value:5.90E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:3.06|P-value:9.96E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.18|P-value:6.60E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.22|P-value:5.76E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.08|P-value:2.00E-7 ID:SGTC_641|Compound:4092-0595|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.27|P-value:9.61E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:4.95|P-value:3.91E-7 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.02|P-value:6.77E-7 ID:SGTC_782|Compound:0083-0095|FD-Score:5.43|P-value:3.13E-8 ID:SGTC_839|Compound:0122-0028|FD-Score:4.65|P-value:1.63E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.29|P-value:4.57E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.53|P-value:3.71E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.07|P-value:9.68E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-3.25|P-value:9.77E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.26|P-value:9.63E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.26|P-value:5.00E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.12|P-value:8.09E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.21|P-value:6.12E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.28|P-value:8.92E-6 ID:SGTC_2054|Compound:5233173|FD-Score:5.23|P-value:8.92E-8 ID:SGTC_2085|Compound:5307070|FD-Score:-3.86|P-value:1.09E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.39|P-value:3.18E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.07|P-value:9.66E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.80|P-value:1.41E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.27|P-value:4.81E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.82|P-value:1.31E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.85|P-value:1.13E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.19|P-value:6.52E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-4.53|P-value:6.69E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.88|P-value:1.03E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.27|P-value:2.71E-13 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.44|P-value:5.22E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.63|P-value:4.23E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.51|P-value:4.05E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.92|P-value:1.11E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-5.78|P-value:1.23E-8 ID:SGTC_2683|Compound:piperine|FD-Score:3.29|P-value:4.60E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.13|P-value:3.82E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.37|P-value:3.39E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.53|P-value:6.73E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-6.43|P-value:2.51E-10 ID:SGTC_3301|Compound:9125354|FD-Score:4.24|P-value:1.07E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.80|P-value:1.38E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.22|P-value:5.90E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:3.06|P-value:9.96E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.18|P-value:6.60E-4 ID:SGTC_251|Compound:melphalan|FD-Score:3.22|P-value:5.76E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.08|P-value:2.00E-7 ID:SGTC_641|Compound:4092-0595|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:4.27|P-value:9.61E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:4.95|P-value:3.91E-7 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.02|P-value:6.77E-7 ID:SGTC_782|Compound:0083-0095|FD-Score:5.43|P-value:3.13E-8 ID:SGTC_839|Compound:0122-0028|FD-Score:4.65|P-value:1.63E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.29|P-value:4.57E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.53|P-value:3.71E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.07|P-value:9.68E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-3.25|P-value:9.77E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.26|P-value:9.63E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.26|P-value:5.00E-4 ID:SGTC_1805|Compound:st050013|FD-Score:3.12|P-value:8.09E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.21|P-value:6.12E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.28|P-value:8.92E-6 ID:SGTC_2054|Compound:5233173|FD-Score:5.23|P-value:8.92E-8 ID:SGTC_2085|Compound:5307070|FD-Score:-3.86|P-value:1.09E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.39|P-value:3.18E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.07|P-value:9.66E-4 ID:SGTC_2372|Compound:9071633|FD-Score:-3.80|P-value:1.41E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.27|P-value:4.81E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.82|P-value:1.31E-4 ID:SGTC_2393|Compound:9031399|FD-Score:-3.85|P-value:1.13E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.19|P-value:6.52E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-4.53|P-value:6.69E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.88|P-value:1.03E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.27|P-value:2.71E-13 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.44|P-value:5.22E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.63|P-value:4.23E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-3.51|P-value:4.05E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.92|P-value:1.11E-6 ID:SGTC_2624|Compound:nerol|FD-Score:-5.78|P-value:1.23E-8 ID:SGTC_2683|Compound:piperine|FD-Score:3.29|P-value:4.60E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-4.13|P-value:3.82E-5 ID:SGTC_2874|Compound:9043904|FD-Score:3.37|P-value:3.39E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.53|P-value:6.73E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-6.43|P-value:2.51E-10 ID:SGTC_3301|Compound:9125354|FD-Score:4.24|P-value:1.07E-5 ID:SGTC_3327|Compound:9140648|FD-Score:3.56|P-value:1.74E-4

Top fitness defect scores for YER156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 7.27 8.5 µM 2.71E-13 5 1.86E-13
2 SGTC_782 0083-0095 5.43 30.5 µM 3.13E-8 8 2.88E-8
3 SGTC_2054 5233173 5.23 129.0 µM 8.92E-8 mitochondrial response to ROS 20 8.39E-8
4 SGTC_385 1494-0393 5.08 12.4 µM 2.00E-7 6 1.92E-7
5 SGTC_744 1594-0068 4.95 283.0 µM 3.91E-7 amide catabolism 11 3.79E-7
6 SGTC_839 0122-0028 4.65 230.0 µM 1.63E-6 RSC complex & mRNA processing 19 1.63E-6
7 SGTC_1934 st074720 4.28 32.6 µM 8.92E-6 39 9.21E-6
8 SGTC_651 3253-0966 4.27 34.4 µM 9.61E-6 calcium & mitochondrial duress 23 9.94E-6
9 SGTC_3301 9125354 4.24 19.8 µM 1.07E-5 11 1.11E-5
10 SGTC_316 k060-0003 3.66 58.6 µM 1.18E-4 21 1.28E-4
11 SGTC_641 4092-0595 3.63 30.0 µM 1.31E-4 17 1.41E-4
12 SGTC_3327 9140648 3.56 26.9 µM 1.74E-4 18 1.88E-4
13 SGTC_2181 6316240 3.39 54.3 µM 3.18E-4 41 3.48E-4
14 SGTC_2874 9043904 3.37 71.4 µM 3.39E-4 30 3.72E-4
15 SGTC_908 3448-7491 3.29 47.7 µM 4.57E-4 mitochondrial stress 174 5.02E-4
16 SGTC_2683 piperine 3.29 63.0 µM 4.60E-4 32 5.06E-4
17 SGTC_2380 9035439 3.27 200.0 µM 4.81E-4 endomembrane recycling 57 5.29E-4
18 SGTC_1719 st032227 3.26 49.2 µM 5.00E-4 47 5.50E-4
19 SGTC_971 1315-0384 3.25 26.7 µM 5.17E-4 cell wall signaling 58 5.69E-4
20 SGTC_251 melphalan 3.22 456.5 µM 5.76E-4 DNA damage response 58 6.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.23E-15 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.137 1.42E-15 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.113 4.96E-11 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.109 2.85E-10 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.101 4.57E-9 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex
0.091 1.35E-7 YEL038W UTR4 hom Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
0.090 1.86E-7 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.090 2.03E-7 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.088 3.15E-7 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.088 3.30E-7 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.087 4.05E-7 YLR125W_p YLR125W_p hom Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
0.087 5.03E-7 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.085 7.59E-7 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 7.81E-7 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.085 8.00E-7 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth