YER158C_p

Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER158C / YER158C

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:3.42|P-value:2.60E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.73|P-value:6.42E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.22|P-value:6.10E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.08|P-value:6.77E-7 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.22|P-value:6.15E-5 ID:SGTC_441|Compound:propafenone|FD-Score:-3.64|P-value:6.87E-6 ID:SGTC_443|Compound:clozapine|FD-Score:-4.06|P-value:6.30E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.18|P-value:8.39E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:4.05|P-value:8.48E-7 ID:SGTC_593|Compound:1203-0218|FD-Score:-2.68|P-value:6.75E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:2.72|P-value:6.71E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-2.72|P-value:5.64E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.85|P-value:2.63E-6 ID:SGTC_688|Compound:0527-0193|FD-Score:3.38|P-value:3.21E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.92|P-value:2.45E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.60|P-value:9.29E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-4.26|P-value:1.89E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:3.30|P-value:4.73E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.23|P-value:5.73E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:2.91|P-value:2.87E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.41|P-value:2.72E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.84|P-value:2.76E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.21|P-value:7.33E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:5.02|P-value:1.38E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.63|P-value:9.59E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.39|P-value:9.95E-8 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.05|P-value:8.25E-7 ID:SGTC_1521|Compound:st012942|FD-Score:4.89|P-value:3.48E-9 ID:SGTC_1534|Compound:6-azauridine|FD-Score:2.93|P-value:2.66E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.98|P-value:2.19E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.48|P-value:1.91E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.29|P-value:1.91E-7 ID:SGTC_1622|Compound:st003707|FD-Score:3.25|P-value:6.20E-5 ID:SGTC_1644|Compound:st010134|FD-Score:2.77|P-value:5.40E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.39|P-value:3.03E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.83|P-value:2.92E-6 ID:SGTC_1706|Compound:st031321|FD-Score:3.53|P-value:1.51E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.09|P-value:1.31E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.25|P-value:6.10E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-2.70|P-value:6.16E-4 ID:SGTC_1901|Compound:st060216|FD-Score:2.62|P-value:9.97E-4 ID:SGTC_1964|Compound:st076914|FD-Score:2.63|P-value:9.35E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.10|P-value:6.19E-7 ID:SGTC_2003|Compound:4023581|FD-Score:2.98|P-value:2.13E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.82|P-value:3.72E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.28|P-value:5.17E-5 ID:SGTC_2106|Compound:5357045|FD-Score:2.92|P-value:2.80E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.65|P-value:8.62E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-2.59|P-value:9.68E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.21|P-value:3.12E-7 ID:SGTC_2273|Compound:7815444|FD-Score:3.30|P-value:4.81E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.02|P-value:1.78E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.48|P-value:1.98E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-2.79|P-value:4.37E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.49|P-value:1.83E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.02|P-value:1.81E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.28|P-value:1.99E-7 ID:SGTC_2742|Compound:clothiapine|FD-Score:2.89|P-value:3.16E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.62|P-value:9.94E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.68|P-value:5.66E-6 ID:SGTC_2787|Compound:5284540|FD-Score:5.21|P-value:3.40E-10 ID:SGTC_2952|Compound:9073731|FD-Score:2.62|P-value:9.79E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.17|P-value:8.88E-5 ID:SGTC_3029|Compound:9088683|FD-Score:4.78|P-value:7.64E-9 ID:SGTC_3049|Compound:9092223|FD-Score:2.82|P-value:4.30E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.71|P-value:5.84E-6 ID:SGTC_3082|Compound:9117008|FD-Score:2.72|P-value:6.71E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-2.77|P-value:4.57E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.68|P-value:1.23E-8 ID:SGTC_3344|Compound:9148862|FD-Score:2.91|P-value:2.88E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.42|P-value:2.60E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.73|P-value:6.42E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.22|P-value:6.10E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:4.08|P-value:6.77E-7 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.22|P-value:6.15E-5 ID:SGTC_441|Compound:propafenone|FD-Score:-3.64|P-value:6.87E-6 ID:SGTC_443|Compound:clozapine|FD-Score:-4.06|P-value:6.30E-7 ID:SGTC_444|Compound:curcumin|FD-Score:3.18|P-value:8.39E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:4.05|P-value:8.48E-7 ID:SGTC_593|Compound:1203-0218|FD-Score:-2.68|P-value:6.75E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:2.72|P-value:6.71E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-2.72|P-value:5.64E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.85|P-value:2.63E-6 ID:SGTC_688|Compound:0527-0193|FD-Score:3.38|P-value:3.21E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.92|P-value:2.45E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.60|P-value:9.29E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-4.26|P-value:1.89E-7 ID:SGTC_876|Compound:0720-0963|FD-Score:3.30|P-value:4.73E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.23|P-value:5.73E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:2.91|P-value:2.87E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.41|P-value:2.72E-5 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.84|P-value:2.76E-6 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.21|P-value:7.33E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:5.02|P-value:1.38E-9 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.63|P-value:9.59E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.39|P-value:9.95E-8 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.05|P-value:8.25E-7 ID:SGTC_1521|Compound:st012942|FD-Score:4.89|P-value:3.48E-9 ID:SGTC_1534|Compound:6-azauridine|FD-Score:2.93|P-value:2.66E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.98|P-value:2.19E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.48|P-value:1.91E-5 ID:SGTC_1606|Compound:st000094|FD-Score:4.29|P-value:1.91E-7 ID:SGTC_1622|Compound:st003707|FD-Score:3.25|P-value:6.20E-5 ID:SGTC_1644|Compound:st010134|FD-Score:2.77|P-value:5.40E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.39|P-value:3.03E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.83|P-value:2.92E-6 ID:SGTC_1706|Compound:st031321|FD-Score:3.53|P-value:1.51E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.09|P-value:1.31E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.25|P-value:6.10E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-2.70|P-value:6.16E-4 ID:SGTC_1901|Compound:st060216|FD-Score:2.62|P-value:9.97E-4 ID:SGTC_1964|Compound:st076914|FD-Score:2.63|P-value:9.35E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.10|P-value:6.19E-7 ID:SGTC_2003|Compound:4023581|FD-Score:2.98|P-value:2.13E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.82|P-value:3.72E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.28|P-value:5.17E-5 ID:SGTC_2106|Compound:5357045|FD-Score:2.92|P-value:2.80E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.65|P-value:8.62E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-2.59|P-value:9.68E-4 ID:SGTC_2266|Compound:7929956|FD-Score:4.21|P-value:3.12E-7 ID:SGTC_2273|Compound:7815444|FD-Score:3.30|P-value:4.81E-5 ID:SGTC_2444|Compound:5485484|FD-Score:3.02|P-value:1.78E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.48|P-value:1.98E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-2.79|P-value:4.37E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.49|P-value:1.83E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:3.02|P-value:1.81E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.28|P-value:1.99E-7 ID:SGTC_2742|Compound:clothiapine|FD-Score:2.89|P-value:3.16E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:2.62|P-value:9.94E-4 ID:SGTC_2783|Compound:7738165|FD-Score:-3.68|P-value:5.66E-6 ID:SGTC_2787|Compound:5284540|FD-Score:5.21|P-value:3.40E-10 ID:SGTC_2952|Compound:9073731|FD-Score:2.62|P-value:9.79E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.17|P-value:8.88E-5 ID:SGTC_3029|Compound:9088683|FD-Score:4.78|P-value:7.64E-9 ID:SGTC_3049|Compound:9092223|FD-Score:2.82|P-value:4.30E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.71|P-value:5.84E-6 ID:SGTC_3082|Compound:9117008|FD-Score:2.72|P-value:6.71E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-2.77|P-value:4.57E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.68|P-value:1.23E-8 ID:SGTC_3344|Compound:9148862|FD-Score:2.91|P-value:2.88E-4

Top fitness defect scores for YER158C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2787 5284540 5.21 71.4 µM 3.40E-10 8 9.41E-8
2 SGTC_1180 1193-0155 5.02 285.0 µM 1.38E-9 3 2.58E-7
3 SGTC_1521 st012942 4.89 49.4 µM 3.48E-9 14 5.00E-7
4 SGTC_3029 9088683 4.78 49.5 µM 7.64E-9 13 8.80E-7
5 SGTC_1452 4194-0072 4.39 190.0 µM 9.95E-8 5 5.57E-6
6 SGTC_1606 st000094 4.29 49.2 µM 1.91E-7 60S ribosome export 10 8.93E-6
7 SGTC_2690 usnic acid 4.28 100.0 µM 1.99E-7 23 9.18E-6
8 SGTC_2266 7929956 4.21 200.0 µM 3.12E-7 25 1.27E-5
9 SGTC_1975 st070967 4.10 30.8 µM 6.19E-7 30 2.08E-5
10 SGTC_169 k015-0017 4.08 16.0 µM 6.77E-7 16 2.22E-5
11 SGTC_1454 4239-0054 4.05 42.6 µM 8.25E-7 32 2.56E-5
12 SGTC_552 k242-0005 4.05 476.0 µM 8.48E-7 14 2.61E-5
13 SGTC_686 1319-0111 3.85 510.0 µM 2.63E-6 60S ribosome export 31 5.91E-5
14 SGTC_1142 3253-1408 3.84 9.8 µM 2.76E-6 13 6.12E-5
15 SGTC_1691 st019933 3.83 84.6 µM 2.92E-6 15 6.38E-5
16 SGTC_3065 9113888 3.71 49.5 µM 5.84E-6 30 1.05E-4
17 SGTC_1706 st031321 3.53 10.0 µM 1.51E-5 TSC3-RPN4 20 2.09E-4
18 SGTC_2678 equilin 3.49 100.0 µM 1.83E-5 34 2.40E-4
19 SGTC_1583 clindamycin 3.48 39.6 µM 1.91E-5 mitochondrial processes 31 2.48E-4
20 SGTC_2487 5918373 3.48 44.0 µM 1.98E-5 27 2.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.47E-8 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.097 1.77E-8 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.087 5.12E-7 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.080 3.26E-6 YBR269C_p FMP21_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.079 4.48E-6 YOR358W HAP5 hom Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
0.075 1.22E-5 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.074 1.64E-5 YER075C PTP3 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
0.073 2.08E-5 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
0.073 2.09E-5 YHR007C-A_p YHR007C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.071 3.81E-5 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.071 3.91E-5 YNR019W ARE2 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication
0.071 4.29E-5 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.070 4.76E-5 YFR040W SAP155 hom Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress
0.070 5.48E-5 YNL087W TCB2 hom ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
0.069 6.09E-5 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins