HIPHOP chemogenomics database

YER164W / CHD1

Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes

Zygosity: Homozygous strain

fixedexpanded
Profile for YER164W / CHD1

Click on Significant Values for Screen Details

Top fitness defect scores for YER164W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2996	9066192	9.18	71.4 µM	2.20E-17		2	2.17E-20
2	SGTC_3152	9099253	7.20	49.5 µM	2.27E-11	NEO1-PIK1	39	3.10E-13
3	SGTC_2599	2',3-dihydroxy-4,4',6'-trimethoxychalcone	6.27	100.0 µM	4.85E-9		4	1.81E-10
4	SGTC_1707	st032323	5.37	6.3 µM	4.43E-7	DNA damage response	28	3.86E-8
5	SGTC_3075	9116269	5.16	49.5 µM	1.18E-6		7	1.24E-7
6	SGTC_2239	6685329	5.09	187.6 µM	1.63E-6		8	1.81E-7
7	SGTC_684	1140-0066	5.03	328.0 µM	2.06E-6	Golgi	9	2.39E-7
8	SGTC_3127	9126946	4.88	49.5 µM	4.08E-6	ERG2	7	5.38E-7
9	SGTC_2575	plumbagin	4.86	510.0 nM	4.42E-6	superoxide	21	5.91E-7
10	SGTC_1279	0874-0590	4.82	65.2 µM	5.12E-6		19	7.04E-7
11	SGTC_2617	dihydrotanshinone i	4.76	20.8 µM	6.56E-6	copper-dependent oxidative stress	16	9.45E-7
12	SGTC_370	0180-0345	4.76	38.7 µM	6.81E-6	DNA intercalators	6	9.88E-7
13	SGTC_2512	diallyl trisulfide	4.60	49.2 µM	1.28E-5		2	2.08E-6
14	SGTC_1844	rapamycin	4.43	4.0 nM	2.56E-5		132	4.75E-6
15	SGTC_1613	st002381	4.42	52.1 µM	2.64E-5		14	4.93E-6
16	SGTC_3158	9100007	4.26	49.5 µM	4.85E-5		13	1.01E-5
17	SGTC_1339	1486-1321	4.25	22.7 µM	5.06E-5	ERG2	13	1.06E-5
18	SGTC_625	k213-0058	4.20	121.0 µM	6.04E-5	translation	90	1.31E-5
19	SGTC_1616	st002734	4.15	56.1 µM	7.48E-5		25	1.69E-5
20	SGTC_2054	5233173	4.12	129.0 µM	8.26E-5	mitochondrial response to ROS	49	1.90E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.153	5.99E-19	YJL092W	SRS2	hom	DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.103	1.86E-9	YDL059C	RAD59	hom	Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.103	2.46E-9	YDL083C	RPS16B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication
0.101	5.08E-9	YOR141C	ARP8	hom	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.097	1.95E-8	YLL061W	MMP1	hom	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
0.092	8.09E-8	YJR075W	HOC1	hom	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.092	8.29E-8	YER016W	BIM1	hom	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.092	1.08E-7	YBR088C	POL30	het	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
0.088	3.40E-7	YML121W	GTR1	hom	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.087	4.95E-7	YNL149C	PGA2	het	Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.084	1.11E-6	YNL244C	SUI1	het	Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.084	1.14E-6	YCR051W_p	YCR051W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
0.083	1.47E-6	YBL071C_d	YBL071C_d	hom	Dubious open reading frame, predicted protein contains a peroxisomal targeting signal
0.082	2.11E-6	YLL026W	HSP104	hom	Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.079	4.82E-6	YJL187C	SWE1	hom	Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate