YER167W / BCK2

Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations

Zygosity: Homozygous strain
fixedexpanded
Profile for YER167W / BCK2

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.46|P-value:6.18E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.88|P-value:1.48E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.49|P-value:1.29E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.57|P-value:8.59E-8 ID:SGTC_206|Compound:4546-0025|FD-Score:3.68|P-value:2.95E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.43|P-value:7.00E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.98|P-value:1.51E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:3.64|P-value:3.37E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.01|P-value:9.02E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.48|P-value:5.86E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.48|P-value:3.93E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.99|P-value:9.76E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:5.51|P-value:1.17E-7 ID:SGTC_901|Compound:1112-0062|FD-Score:4.19|P-value:4.42E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.70|P-value:2.78E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.36|P-value:8.62E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.78|P-value:2.05E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.89|P-value:1.38E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.90|P-value:8.51E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:5.61|P-value:6.87E-8 ID:SGTC_1155|Compound:4088-0394|FD-Score:7.23|P-value:5.10E-12 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.37|P-value:2.14E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.05|P-value:7.54E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.81|P-value:3.25E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.41|P-value:1.83E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.87|P-value:2.47E-6 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.37|P-value:8.57E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.80|P-value:1.91E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:5.13|P-value:7.54E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.31|P-value:2.76E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.61|P-value:6.95E-8 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.59|P-value:8.66E-6 ID:SGTC_2085|Compound:5307070|FD-Score:3.84|P-value:1.68E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.84|P-value:1.69E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.03|P-value:8.26E-5 ID:SGTC_2180|Compound:6301957|FD-Score:4.65|P-value:6.76E-6 ID:SGTC_2181|Compound:6316240|FD-Score:3.97|P-value:1.04E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.68|P-value:3.00E-4 ID:SGTC_2210|Compound:7115885|FD-Score:4.38|P-value:2.07E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.43|P-value:6.96E-4 ID:SGTC_2299|Compound:7976368|FD-Score:7.51|P-value:7.52E-13 ID:SGTC_2301|Compound:7769476|FD-Score:3.96|P-value:1.06E-4 ID:SGTC_2413|Compound:inermin|FD-Score:6.24|P-value:2.27E-9 ID:SGTC_2463|Compound:5473429|FD-Score:3.79|P-value:1.98E-4 ID:SGTC_2474|Compound:5321570|FD-Score:5.71|P-value:4.05E-8 ID:SGTC_2479|Compound:5617353|FD-Score:3.37|P-value:8.57E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.33|P-value:9.54E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.94|P-value:1.15E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.65|P-value:2.00E-10 ID:SGTC_2702|Compound:st077768|FD-Score:4.56|P-value:9.60E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.57|P-value:4.38E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.67|P-value:3.12E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.34|P-value:2.49E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.32|P-value:9.77E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.37|P-value:2.19E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.57|P-value:4.32E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.89|P-value:1.57E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:3.46|P-value:6.18E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.88|P-value:1.48E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:4.49|P-value:1.29E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.57|P-value:8.59E-8 ID:SGTC_206|Compound:4546-0025|FD-Score:3.68|P-value:2.95E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.43|P-value:7.00E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.98|P-value:1.51E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:3.64|P-value:3.37E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.01|P-value:9.02E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.48|P-value:5.86E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.48|P-value:3.93E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:3.99|P-value:9.76E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:5.51|P-value:1.17E-7 ID:SGTC_901|Compound:1112-0062|FD-Score:4.19|P-value:4.42E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.70|P-value:2.78E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.36|P-value:8.62E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.78|P-value:2.05E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.89|P-value:1.38E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.90|P-value:8.51E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.76|P-value:2.27E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:5.61|P-value:6.87E-8 ID:SGTC_1155|Compound:4088-0394|FD-Score:7.23|P-value:5.10E-12 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.37|P-value:2.14E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.05|P-value:7.54E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.81|P-value:3.25E-6 ID:SGTC_1310|Compound:1188-0297|FD-Score:4.41|P-value:1.83E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.87|P-value:2.47E-6 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.37|P-value:8.57E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.80|P-value:1.91E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:5.13|P-value:7.54E-7 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:4.31|P-value:2.76E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:5.61|P-value:6.95E-8 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.59|P-value:8.66E-6 ID:SGTC_2085|Compound:5307070|FD-Score:3.84|P-value:1.68E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.84|P-value:1.69E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.03|P-value:8.26E-5 ID:SGTC_2180|Compound:6301957|FD-Score:4.65|P-value:6.76E-6 ID:SGTC_2181|Compound:6316240|FD-Score:3.97|P-value:1.04E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.68|P-value:3.00E-4 ID:SGTC_2210|Compound:7115885|FD-Score:4.38|P-value:2.07E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.43|P-value:6.96E-4 ID:SGTC_2299|Compound:7976368|FD-Score:7.51|P-value:7.52E-13 ID:SGTC_2301|Compound:7769476|FD-Score:3.96|P-value:1.06E-4 ID:SGTC_2413|Compound:inermin|FD-Score:6.24|P-value:2.27E-9 ID:SGTC_2463|Compound:5473429|FD-Score:3.79|P-value:1.98E-4 ID:SGTC_2474|Compound:5321570|FD-Score:5.71|P-value:4.05E-8 ID:SGTC_2479|Compound:5617353|FD-Score:3.37|P-value:8.57E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.33|P-value:9.54E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.94|P-value:1.15E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.65|P-value:2.00E-10 ID:SGTC_2702|Compound:st077768|FD-Score:4.56|P-value:9.60E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:3.57|P-value:4.38E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.67|P-value:3.12E-4 ID:SGTC_2826|Compound:7992541|FD-Score:4.34|P-value:2.49E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.32|P-value:9.77E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.37|P-value:2.19E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.57|P-value:4.32E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.89|P-value:1.57E-8

Top fitness defect scores for YER167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2299 7976368 7.51 114.9 µM 7.52E-13 5 2.86E-14
2 SGTC_1155 4088-0394 7.23 48.2 µM 5.10E-12 1 2.43E-13
3 SGTC_2583 asiatic acid 6.65 100.0 µM 2.00E-10 4 1.47E-11
4 SGTC_2413 inermin 6.24 26.1 µM 2.27E-9 16 2.21E-10
5 SGTC_3203 9113543 5.89 49.5 µM 1.57E-8 5 1.92E-9
6 SGTC_2474 5321570 5.71 43.3 µM 4.05E-8 1 5.54E-9
7 SGTC_1146 3579-1023 5.61 7.0 µM 6.87E-8 4 9.99E-9
8 SGTC_1574 spiramycin 5.61 23.7 µM 6.95E-8 5 1.01E-8
9 SGTC_138 0850-0259 5.57 40.9 µM 8.59E-8 cell wall 121 1.28E-8
10 SGTC_890 0929-0006 5.51 47.2 µM 1.17E-7 5 1.81E-8
11 SGTC_1484 3473-2379 5.13 286.0 µM 7.54E-7 4 1.46E-7
12 SGTC_428 3448-4153 4.98 16.5 µM 1.51E-6 TSC3-RPN4 14 3.15E-7
13 SGTC_1342 1486-1464 4.87 234.0 µM 2.47E-6 4 5.47E-7
14 SGTC_1204 4049-0315 4.81 18.3 µM 3.25E-6 7 7.45E-7
15 SGTC_2180 6301957 4.65 200.0 µM 6.76E-6 RSC complex & mRNA processing 1 1.69E-6
16 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 4.59 67.5 µM 8.66E-6 23 2.23E-6
17 SGTC_2702 st077768 4.56 96.8 µM 9.60E-6 10 2.51E-6
18 SGTC_117 lucigenin 4.49 22.1 µM 1.29E-5 redox potentiating 67 3.48E-6
19 SGTC_1310 1188-0297 4.41 994.0 nM 1.83E-5 azole & statin 21 5.15E-6
20 SGTC_2210 7115885 4.38 190.4 µM 2.07E-5 cell wall signaling 24 5.93E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.30E-14 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.116 1.57E-11 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.112 8.76E-11 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.110 1.55E-10 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.103 2.46E-9 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.102 3.01E-9 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.100 6.67E-9 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.098 1.38E-8 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.096 2.24E-8 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.096 2.98E-8 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.095 3.62E-8 YNL271C BNI1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
0.095 4.11E-8 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.093 6.70E-8 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.093 7.94E-8 YOR026W BUB3 hom Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
0.092 8.10E-8 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel