HIPHOP chemogenomics database

YER167W / BCK2

Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations

Zygosity: Homozygous strain

fixedexpanded
Profile for YER167W / BCK2

Click on Significant Values for Screen Details

Top fitness defect scores for YER167W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2299	7976368	7.51	114.9 µM	7.52E-13		5	2.86E-14
2	SGTC_1155	4088-0394	7.23	48.2 µM	5.10E-12		1	2.43E-13
3	SGTC_2583	asiatic acid	6.65	100.0 µM	2.00E-10		4	1.47E-11
4	SGTC_2413	inermin	6.24	26.1 µM	2.27E-9		16	2.21E-10
5	SGTC_3203	9113543	5.89	49.5 µM	1.57E-8		5	1.92E-9
6	SGTC_2474	5321570	5.71	43.3 µM	4.05E-8		1	5.54E-9
7	SGTC_1146	3579-1023	5.61	7.0 µM	6.87E-8		4	9.99E-9
8	SGTC_1574	spiramycin	5.61	23.7 µM	6.95E-8		5	1.01E-8
9	SGTC_138	0850-0259	5.57	40.9 µM	8.59E-8	cell wall	121	1.28E-8
10	SGTC_890	0929-0006	5.51	47.2 µM	1.17E-7		5	1.81E-8
11	SGTC_1484	3473-2379	5.13	286.0 µM	7.54E-7		4	1.46E-7
12	SGTC_428	3448-4153	4.98	16.5 µM	1.51E-6	TSC3-RPN4	14	3.15E-7
13	SGTC_1342	1486-1464	4.87	234.0 µM	2.47E-6		4	5.47E-7
14	SGTC_1204	4049-0315	4.81	18.3 µM	3.25E-6		7	7.45E-7
15	SGTC_2180	6301957	4.65	200.0 µM	6.76E-6	RSC complex & mRNA processing	1	1.69E-6
16	SGTC_1595	6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin	4.59	67.5 µM	8.66E-6		23	2.23E-6
17	SGTC_2702	st077768	4.56	96.8 µM	9.60E-6		10	2.51E-6
18	SGTC_117	lucigenin	4.49	22.1 µM	1.29E-5	redox potentiating	67	3.48E-6
19	SGTC_1310	1188-0297	4.41	994.0 nM	1.83E-5	azole & statin	21	5.15E-6
20	SGTC_2210	7115885	4.38	190.4 µM	2.07E-5	cell wall signaling	24	5.93E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.131	3.30E-14	YFL038C	YPT1	het	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.116	1.57E-11	YBR023C	CHS3	hom	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.112	8.76E-11	YPL066W	RGL1	hom	Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.110	1.55E-10	YJL099W	CHS6	hom	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.103	2.46E-9	YKL048C	ELM1	hom	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.102	3.01E-9	YLL021W	SPA2	hom	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.100	6.67E-9	YNL233W	BNI4	hom	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.098	1.38E-8	YNR016C	ACC1	het	Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.096	2.24E-8	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.096	2.98E-8	YEL003W	GIM4	hom	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.095	3.62E-8	YNL271C	BNI1	hom	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
0.095	4.11E-8	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.093	6.70E-8	YKL183W	LOT5	hom	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.093	7.94E-8	YOR026W	BUB3	hom	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
0.092	8.10E-8	YPL063W	TIM50	het	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel