YER170W / ADK2

Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background

Zygosity: Homozygous strain
fixedexpanded
Profile for YER170W / ADK2

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.68|P-value:1.56E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.99|P-value:4.74E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:4.16|P-value:2.41E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.83|P-value:1.00E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.37|P-value:4.93E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.03|P-value:4.14E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.99|P-value:5.43E-7 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.23|P-value:7.88E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.41|P-value:4.23E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.32|P-value:5.72E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.79|P-value:1.07E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.32|P-value:5.81E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.59|P-value:2.24E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.47|P-value:3.40E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.57|P-value:2.38E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.30|P-value:6.98E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.60|P-value:2.43E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.23|P-value:7.79E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.09|P-value:3.64E-5 ID:SGTC_2037|Compound:5169046|FD-Score:3.25|P-value:7.33E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.00|P-value:4.66E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-3.68|P-value:1.81E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.21|P-value:8.48E-4 ID:SGTC_2255|Compound:7941087|FD-Score:4.19|P-value:2.07E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.33|P-value:5.64E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.64|P-value:1.83E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.28|P-value:7.29E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.21|P-value:1.95E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.48|P-value:3.35E-4 ID:SGTC_2423|Compound:st077119|FD-Score:5.33|P-value:9.44E-8 ID:SGTC_2431|Compound:5490079|FD-Score:3.89|P-value:7.21E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-3.60|P-value:2.38E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.72|P-value:1.53E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.24|P-value:1.72E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.30|P-value:6.11E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.39|P-value:4.52E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.95|P-value:5.52E-5 ID:SGTC_3139|Compound:9095020|FD-Score:-4.61|P-value:3.87E-6 ID:SGTC_3143|Compound:9086658|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.46|P-value:7.43E-6 ID:SGTC_3215|Compound:9129942|FD-Score:-3.47|P-value:3.81E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.68|P-value:1.56E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.99|P-value:4.74E-5 ID:SGTC_112|Compound:phenothiazine|FD-Score:4.16|P-value:2.41E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.83|P-value:1.00E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.37|P-value:4.93E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.03|P-value:4.14E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.99|P-value:5.43E-7 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.23|P-value:7.88E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.41|P-value:4.23E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.32|P-value:5.72E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.79|P-value:1.07E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.32|P-value:5.81E-4 ID:SGTC_1765|Compound:st044815|FD-Score:3.59|P-value:2.24E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.47|P-value:3.40E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.57|P-value:2.38E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.30|P-value:6.98E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-3.60|P-value:2.43E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.23|P-value:7.79E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-4.09|P-value:3.64E-5 ID:SGTC_2037|Compound:5169046|FD-Score:3.25|P-value:7.33E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.00|P-value:4.66E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-3.68|P-value:1.81E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.21|P-value:8.48E-4 ID:SGTC_2255|Compound:7941087|FD-Score:4.19|P-value:2.07E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.33|P-value:5.64E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.64|P-value:1.83E-4 ID:SGTC_2368|Compound:9071271|FD-Score:-3.28|P-value:7.29E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.21|P-value:1.95E-5 ID:SGTC_2397|Compound:5161689|FD-Score:3.48|P-value:3.35E-4 ID:SGTC_2423|Compound:st077119|FD-Score:5.33|P-value:9.44E-8 ID:SGTC_2431|Compound:5490079|FD-Score:3.89|P-value:7.21E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-3.60|P-value:2.38E-4 ID:SGTC_2712|Compound:st079126|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.72|P-value:1.53E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.24|P-value:1.72E-5 ID:SGTC_2922|Compound:7999257|FD-Score:3.30|P-value:6.11E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.39|P-value:4.52E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.95|P-value:5.52E-5 ID:SGTC_3139|Compound:9095020|FD-Score:-4.61|P-value:3.87E-6 ID:SGTC_3143|Compound:9086658|FD-Score:3.57|P-value:2.37E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.46|P-value:7.43E-6 ID:SGTC_3215|Compound:9129942|FD-Score:-3.47|P-value:3.81E-4

Top fitness defect scores for YER170W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2423 st077119 5.33 87.2 µM 9.44E-8 4 4.83E-8
2 SGTC_1186 1319-0216 4.99 26.0 µM 5.43E-7 5 3.03E-7
3 SGTC_2775 cyproheptadine 4.24 69.6 µM 1.72E-5 12 1.13E-5
4 SGTC_2379 9035213 4.21 200.0 µM 1.95E-5 16 1.29E-5
5 SGTC_1561 5-methoxyflavone 4.20 52.9 µM 2.00E-5 5 1.33E-5
6 SGTC_2255 7941087 4.19 197.4 µM 2.07E-5 24 1.38E-5
7 SGTC_112 phenothiazine 4.16 287.2 µM 2.41E-5 unfolded protein response 10 1.62E-5
8 SGTC_1172 0370-0043 4.03 85.0 µM 4.14E-5 22 2.84E-5
9 SGTC_2052 5265182 4.00 7.1 µM 4.66E-5 29 3.23E-5
10 SGTC_73 0327-0325 3.99 16.2 µM 4.74E-5 DNA damage response 50 3.28E-5
11 SGTC_3098 9119039 3.95 49.5 µM 5.52E-5 Golgi 35 3.85E-5
12 SGTC_2431 5490079 3.89 200.0 µM 7.21E-5 39 5.09E-5
13 SGTC_1586 deoxycorticosterone acetate 3.79 53.7 µM 1.07E-4 14 7.67E-5
14 SGTC_18 0111-0177 3.68 500.0 nM 1.56E-4 83 1.14E-4
15 SGTC_2363 9053361 3.64 176.0 µM 1.83E-4 Golgi 39 1.35E-4
16 SGTC_1765 st044815 3.59 90.4 µM 2.24E-4 34 1.67E-4
17 SGTC_3143 9086658 3.57 49.5 µM 2.37E-4 68 1.77E-4
18 SGTC_1847 st056231 3.57 15.0 µM 2.38E-4 39 1.78E-4
19 SGTC_2712 st079126 3.56 47.7 µM 2.47E-4 28 1.84E-4
20 SGTC_2397 5161689 3.48 200.0 µM 3.35E-4 51 2.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 7.87E-14 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.099 9.84E-9 YHR079C-A SAE3 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
0.094 4.49E-8 YPL198W RPL7B hom Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication
0.093 6.05E-8 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.090 1.96E-7 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.089 2.41E-7 YOR161C PNS1 hom Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
0.085 7.76E-7 YNL007C SIS1 het Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress
0.084 1.17E-6 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.084 1.25E-6 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.083 1.32E-6 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.081 2.65E-6 YPL234C VMA11 hom Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
0.081 2.71E-6 YKL186C MTR2 het mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
0.076 1.05E-5 YNL138W SRV2 hom CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
0.075 1.25E-5 YNR027W BUD17 hom Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)
0.075 1.41E-5 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication