YER175W-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YER175W-A / YER175W-A

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.04|P-value:8.62E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.33|P-value:3.04E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.39|P-value:2.38E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.21|P-value:4.74E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.02|P-value:1.71E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.16|P-value:5.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.93|P-value:1.97E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.14|P-value:1.04E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.05|P-value:8.58E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.07|P-value:8.75E-8 ID:SGTC_389|Compound:tpck|FD-Score:3.00|P-value:9.83E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.28|P-value:3.68E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.12|P-value:6.71E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.19|P-value:4.56E-8 ID:SGTC_599|Compound:1935-0052|FD-Score:4.07|P-value:1.41E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:7.54|P-value:4.17E-15 ID:SGTC_817|Compound:1391-0715|FD-Score:3.70|P-value:6.91E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.08|P-value:7.53E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.62|P-value:9.78E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.39|P-value:2.45E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.83|P-value:4.01E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.06|P-value:8.12E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.39|P-value:2.41E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.01|P-value:9.94E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.10|P-value:7.07E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.81|P-value:4.32E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.61|P-value:1.03E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.27|P-value:3.81E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.88|P-value:7.27E-10 ID:SGTC_1954|Compound:st077032|FD-Score:4.05|P-value:1.53E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.21|P-value:4.65E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.05|P-value:8.40E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.25|P-value:4.22E-4 ID:SGTC_2052|Compound:5265182|FD-Score:5.09|P-value:7.97E-8 ID:SGTC_2445|Compound:5742597|FD-Score:4.42|P-value:2.73E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.23|P-value:4.39E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.15|P-value:5.97E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.86|P-value:3.45E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.21|P-value:7.21E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.50|P-value:1.62E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.41|P-value:2.31E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.01|P-value:9.80E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.92|P-value:2.84E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.04|P-value:8.59E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-4.81|P-value:3.82E-7 ID:SGTC_3292|Compound:9120825|FD-Score:3.72|P-value:6.39E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.38|P-value:2.58E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.04|P-value:8.62E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.33|P-value:3.04E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.39|P-value:2.38E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.21|P-value:4.74E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:4.02|P-value:1.71E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:3.16|P-value:5.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.93|P-value:1.97E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:3.48|P-value:1.72E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.14|P-value:1.04E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.05|P-value:8.58E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:5.07|P-value:8.75E-8 ID:SGTC_389|Compound:tpck|FD-Score:3.00|P-value:9.83E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.28|P-value:3.68E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:-3.12|P-value:6.71E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.19|P-value:4.56E-8 ID:SGTC_599|Compound:1935-0052|FD-Score:4.07|P-value:1.41E-5 ID:SGTC_667|Compound:1498-1044|FD-Score:7.54|P-value:4.17E-15 ID:SGTC_817|Compound:1391-0715|FD-Score:3.70|P-value:6.91E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.08|P-value:7.53E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.62|P-value:9.78E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.39|P-value:2.45E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.83|P-value:4.01E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.06|P-value:8.12E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.39|P-value:2.41E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.01|P-value:9.94E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.10|P-value:7.07E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.81|P-value:4.32E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.61|P-value:1.03E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.27|P-value:3.81E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.88|P-value:7.27E-10 ID:SGTC_1954|Compound:st077032|FD-Score:4.05|P-value:1.53E-5 ID:SGTC_1982|Compound:st072467|FD-Score:3.21|P-value:4.65E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.05|P-value:8.40E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.25|P-value:4.22E-4 ID:SGTC_2052|Compound:5265182|FD-Score:5.09|P-value:7.97E-8 ID:SGTC_2445|Compound:5742597|FD-Score:4.42|P-value:2.73E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.23|P-value:4.39E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.15|P-value:5.97E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.86|P-value:3.45E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.21|P-value:7.21E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.50|P-value:1.62E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.41|P-value:2.31E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.01|P-value:9.80E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.92|P-value:2.84E-5 ID:SGTC_3240|Compound:9133527|FD-Score:3.04|P-value:8.59E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-4.81|P-value:3.82E-7 ID:SGTC_3292|Compound:9120825|FD-Score:3.72|P-value:6.39E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.38|P-value:2.58E-4

Top fitness defect scores for YER175W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_667 1498-1044 7.54 59.0 µM 4.17E-15 RPP1 & pyrimidine depletion 1 2.33E-14
2 SGTC_1948 st076329 5.88 66.6 µM 7.27E-10 3 2.10E-9
3 SGTC_588 3970-1144 5.19 52.9 µM 4.56E-8 8 1.05E-7
4 SGTC_2052 5265182 5.09 7.1 µM 7.97E-8 9 1.78E-7
5 SGTC_379 3970-0972 5.07 5.9 µM 8.75E-8 tubulin folding & SWR complex 11 1.95E-7
6 SGTC_236 1509-0011 4.93 5.3 µM 1.97E-7 327 4.20E-7
7 SGTC_2445 5742597 4.42 35.6 µM 2.73E-6 27 5.05E-6
8 SGTC_2633 5,7-dihydroxyisoflavone 4.21 100.0 µM 7.21E-6 27 1.27E-5
9 SGTC_599 1935-0052 4.07 86.5 µM 1.41E-5 19 2.40E-5
10 SGTC_1954 st077032 4.05 68.9 µM 1.53E-5 20 2.58E-5
11 SGTC_204 1543-0184 4.02 62.4 µM 1.71E-5 TRP & mitochondrial translation 30 2.86E-5
12 SGTC_2488 5268135 3.86 45.7 µM 3.45E-5 53 5.57E-5
13 SGTC_1120 ficusin 3.83 1.8 µM 4.01E-5 29 6.42E-5
14 SGTC_1640 st009078 3.81 66.4 µM 4.32E-5 11 6.90E-5
15 SGTC_3292 9120825 3.72 59.8 µM 6.39E-5 15 9.99E-5
16 SGTC_817 1391-0715 3.70 46.0 µM 6.91E-5 22 1.08E-4
17 SGTC_319 1348-1596 3.48 45.5 µM 1.72E-4 RSC & ERG11 31 2.55E-4
18 SGTC_147 4466-0538 3.39 29.2 µM 2.38E-4 ergosterol biosynthesis 44 3.47E-4
19 SGTC_1258 0671-0043 3.39 57.1 µM 2.41E-4 45 3.50E-4
20 SGTC_58 0957-0393 3.33 9.0 µM 3.04E-4 cell wall 449 4.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.25E-17 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.146 1.79E-17 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.141 2.64E-16 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.138 9.25E-16 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.137 1.84E-15 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.137 2.00E-15 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.136 3.01E-15 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.132 1.97E-14 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.131 2.16E-14 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.131 2.45E-14 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.129 6.62E-14 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.127 1.86E-13 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.125 3.96E-13 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.125 4.40E-13 YJR077C MIR1 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
0.124 6.85E-13 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER