YER178W / PDA1

E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YER178W / PDA1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:4.77E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.88|P-value:2.54E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:4.40|P-value:2.03E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.55|P-value:4.10E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.91|P-value:2.22E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.43|P-value:1.76E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:5.35|P-value:2.94E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.56|P-value:4.57E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.32|P-value:9.69E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.32|P-value:9.89E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.35|P-value:9.04E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.52|P-value:5.12E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.60|P-value:3.48E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:4.35|P-value:2.49E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.11|P-value:6.25E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:5.10|P-value:9.31E-7 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.32|P-value:8.86E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.40|P-value:7.64E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.58|P-value:4.17E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.15|P-value:5.45E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.88|P-value:1.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.34|P-value:2.54E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.42|P-value:1.83E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.75|P-value:2.30E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:6.06|P-value:7.46E-9 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.37|P-value:2.28E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.89|P-value:1.42E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.79|P-value:2.06E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.59|P-value:9.25E-6 ID:SGTC_1853|Compound:st056710|FD-Score:4.34|P-value:2.58E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:4.19|P-value:4.56E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.63|P-value:3.49E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.40|P-value:6.83E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.00|P-value:9.47E-5 ID:SGTC_2179|Compound:6298986|FD-Score:4.37|P-value:2.27E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.58|P-value:4.17E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.75|P-value:2.08E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.97|P-value:9.49E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.52|P-value:5.06E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.34|P-value:2.52E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.08|P-value:6.96E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.46|P-value:6.23E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.37|P-value:2.63E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.50|P-value:1.33E-5 ID:SGTC_3208|Compound:9114115|FD-Score:6.00|P-value:1.04E-8 ID:SGTC_3321|Compound:9137793|FD-Score:3.34|P-value:9.24E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.85|P-value:1.65E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-5.94|P-value:1.22E-8 ID:SGTC_3347|Compound:9188721|FD-Score:5.90|P-value:1.81E-8 ID:SGTC_3354|Compound:9151612|FD-Score:-3.36|P-value:7.89E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:4.77E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:4.88|P-value:2.54E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:4.40|P-value:2.03E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.55|P-value:4.10E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:4.91|P-value:2.22E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:4.43|P-value:1.76E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:5.35|P-value:2.94E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.56|P-value:4.57E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.32|P-value:9.69E-4 ID:SGTC_276|Compound:colchicine|FD-Score:3.32|P-value:9.89E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.35|P-value:9.04E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.52|P-value:5.12E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.60|P-value:3.48E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:4.35|P-value:2.49E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:4.11|P-value:6.25E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:5.10|P-value:9.31E-7 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.32|P-value:8.86E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.40|P-value:7.64E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.58|P-value:4.17E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.15|P-value:5.45E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.88|P-value:1.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.34|P-value:2.54E-5 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.42|P-value:1.83E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.75|P-value:2.30E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:6.06|P-value:7.46E-9 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.37|P-value:2.28E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.89|P-value:1.42E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.79|P-value:2.06E-4 ID:SGTC_1772|Compound:st048439|FD-Score:4.59|P-value:9.25E-6 ID:SGTC_1853|Compound:st056710|FD-Score:4.34|P-value:2.58E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:4.19|P-value:4.56E-5 ID:SGTC_1963|Compound:st076565|FD-Score:3.63|P-value:3.49E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.40|P-value:6.83E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.00|P-value:9.47E-5 ID:SGTC_2179|Compound:6298986|FD-Score:4.37|P-value:2.27E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.58|P-value:4.17E-4 ID:SGTC_2398|Compound:5228213|FD-Score:-3.75|P-value:2.08E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.97|P-value:9.49E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.52|P-value:5.06E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.34|P-value:2.52E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:4.08|P-value:6.96E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.46|P-value:6.23E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.37|P-value:2.63E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.50|P-value:1.33E-5 ID:SGTC_3208|Compound:9114115|FD-Score:6.00|P-value:1.04E-8 ID:SGTC_3321|Compound:9137793|FD-Score:3.34|P-value:9.24E-4 ID:SGTC_3325|Compound:9138760|FD-Score:3.85|P-value:1.65E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-5.94|P-value:1.22E-8 ID:SGTC_3347|Compound:9188721|FD-Score:5.90|P-value:1.81E-8 ID:SGTC_3354|Compound:9151612|FD-Score:-3.36|P-value:7.89E-4

Top fitness defect scores for YER178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1582 3',3',6'-trihydroxyflavone 6.06 74.0 µM 7.46E-9 2 6.83E-10
2 SGTC_3208 9114115 6.00 49.5 µM 1.04E-8 10 9.92E-10
3 SGTC_3347 9188721 5.90 44.7 µM 1.81E-8 6 1.87E-9
4 SGTC_2792 7535235 5.37 81.8 µM 2.63E-7 fatty acid desaturase (OLE1) 13 3.93E-8
5 SGTC_157 1348-1695 5.35 65.8 µM 2.94E-7 iron homeostasis 28 4.46E-8
6 SGTC_1065 prochlorperazine maleate 5.10 2.5 µM 9.31E-7 2 1.66E-7
7 SGTC_73 0327-0325 4.91 16.2 µM 2.22E-6 DNA damage response 26 4.45E-7
8 SGTC_7 0192-1582 4.88 4.2 µM 2.54E-6 37 5.18E-7
9 SGTC_1772 st048439 4.59 82.2 µM 9.25E-6 22 2.25E-6
10 SGTC_2858 9025781 4.50 9.0 µM 1.33E-5 sphingolipid biosynthesis & PDR1 76 3.39E-6
11 SGTC_116 0155-0182 4.43 31.8 µM 1.76E-5 mitochondrial response to ROS 59 4.67E-6
12 SGTC_1384 3089-0840 4.42 101.0 µM 1.83E-5 9 4.90E-6
13 SGTC_54 0159-0055 4.40 9.0 µM 2.03E-5 ERG2 38 5.50E-6
14 SGTC_2179 6298986 4.37 200.0 µM 2.27E-5 heme requiring 14 6.25E-6
15 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 4.37 54.9 µM 2.28E-5 redox potentiating 44 6.27E-6
16 SGTC_930 2810-3379 4.35 265.0 µM 2.49E-5 8 6.94E-6
17 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.34 3.7 µM 2.52E-5 61 7.03E-6
18 SGTC_1204 4049-0315 4.34 18.3 µM 2.54E-5 17 7.10E-6
19 SGTC_1853 st056710 4.34 91.2 µM 2.58E-5 amide catabolism 20 7.21E-6
20 SGTC_1880 MG-132 4.19 525.0 µM 4.56E-5 13 1.38E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.67E-14 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.124 4.65E-13 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.108 3.52E-10 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.104 1.39E-9 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.104 1.43E-9 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.104 1.67E-9 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.103 2.33E-9 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.098 1.11E-8 YIR043C YIR043C hom Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.096 2.15E-8 YJL077C ICS3 hom Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2
0.096 2.52E-8 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.093 7.82E-8 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.092 9.95E-8 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.089 2.22E-7 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.085 7.43E-7 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.085 9.21E-7 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data