YER179W / DMC1

Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER179W / DMC1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.42|P-value:1.29E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.45|P-value:1.11E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.05|P-value:5.38E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:2.94|P-value:8.32E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.17|P-value:3.50E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.81|P-value:2.92E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.41|P-value:1.33E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.03|P-value:6.97E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.31|P-value:2.44E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.84|P-value:2.03E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.27|P-value:2.79E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.25|P-value:2.50E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.08|P-value:4.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.39|P-value:1.75E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.12|P-value:5.02E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.75|P-value:2.99E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.08|P-value:4.85E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.05|P-value:6.51E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.37|P-value:1.91E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.81|P-value:2.86E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:5.27|P-value:9.12E-9 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.87|P-value:2.18E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.15|P-value:4.52E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.39|P-value:1.42E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.25|P-value:3.02E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.59|P-value:7.78E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.59|P-value:6.24E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.29|P-value:2.16E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.51|P-value:8.56E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.50|P-value:1.12E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.35|P-value:1.67E-6 ID:SGTC_1686|Compound:st019653|FD-Score:4.19|P-value:3.79E-6 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.57|P-value:6.72E-5 ID:SGTC_1707|Compound:st032323|FD-Score:2.98|P-value:7.15E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.28|P-value:8.95E-9 ID:SGTC_1766|Compound:st045414|FD-Score:2.96|P-value:7.74E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.51|P-value:8.67E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.58|P-value:7.99E-5 ID:SGTC_2044|Compound:5102272|FD-Score:-3.24|P-value:3.22E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-3.33|P-value:2.24E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.99|P-value:6.86E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.23|P-value:2.70E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.97|P-value:1.12E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.04|P-value:3.79E-8 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.74|P-value:4.72E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.77|P-value:3.49E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.99|P-value:1.27E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.10|P-value:4.48E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.36|P-value:1.56E-6 ID:SGTC_2880|Compound:9042983|FD-Score:3.01|P-value:6.36E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.53|P-value:8.09E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.81|P-value:2.33E-5 ID:SGTC_3078|Compound:9116413|FD-Score:3.45|P-value:1.12E-4 ID:SGTC_3109|Compound:9122853|FD-Score:2.98|P-value:7.04E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.35|P-value:1.70E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.96|P-value:7.85E-8 ID:SGTC_3353|Compound:9151644|FD-Score:4.69|P-value:2.71E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:3.42|P-value:1.29E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:3.37|P-value:1.57E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.45|P-value:1.11E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:3.05|P-value:5.38E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:2.94|P-value:8.32E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.17|P-value:3.50E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:-3.81|P-value:2.92E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.41|P-value:1.33E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.03|P-value:6.97E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.34|P-value:1.76E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.31|P-value:2.44E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.84|P-value:2.03E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.27|P-value:2.79E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.25|P-value:2.50E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.08|P-value:4.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.39|P-value:1.75E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.12|P-value:5.02E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.75|P-value:2.99E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.08|P-value:4.85E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.05|P-value:6.51E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.37|P-value:1.91E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.81|P-value:2.86E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:5.27|P-value:9.12E-9 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.87|P-value:2.18E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.15|P-value:4.52E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.39|P-value:1.42E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.25|P-value:3.02E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.59|P-value:7.78E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.59|P-value:6.24E-5 ID:SGTC_1516|Compound:st013856|FD-Score:3.29|P-value:2.16E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.51|P-value:8.56E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.50|P-value:1.12E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.35|P-value:1.67E-6 ID:SGTC_1686|Compound:st019653|FD-Score:4.19|P-value:3.79E-6 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.57|P-value:6.72E-5 ID:SGTC_1707|Compound:st032323|FD-Score:2.98|P-value:7.15E-4 ID:SGTC_1740|Compound:st038286|FD-Score:5.28|P-value:8.95E-9 ID:SGTC_1766|Compound:st045414|FD-Score:2.96|P-value:7.74E-4 ID:SGTC_1811|Compound:st050069|FD-Score:3.51|P-value:8.67E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.58|P-value:7.99E-5 ID:SGTC_2044|Compound:5102272|FD-Score:-3.24|P-value:3.22E-4 ID:SGTC_2063|Compound:5246145|FD-Score:-3.33|P-value:2.24E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.99|P-value:6.86E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.23|P-value:2.70E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.97|P-value:1.12E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.04|P-value:3.79E-8 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.74|P-value:4.72E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-3.77|P-value:3.49E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.99|P-value:1.27E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.10|P-value:4.48E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.36|P-value:1.56E-6 ID:SGTC_2880|Compound:9042983|FD-Score:3.01|P-value:6.36E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.53|P-value:8.09E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.81|P-value:2.33E-5 ID:SGTC_3078|Compound:9116413|FD-Score:3.45|P-value:1.12E-4 ID:SGTC_3109|Compound:9122853|FD-Score:2.98|P-value:7.04E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.35|P-value:1.70E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.96|P-value:7.85E-8 ID:SGTC_3353|Compound:9151644|FD-Score:4.69|P-value:2.71E-7

Top fitness defect scores for YER179W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2528 xanthyletin 5.74 44.8 µM 4.72E-10 7 4.84E-9
2 SGTC_1740 st038286 5.28 13.2 µM 8.95E-9 9 6.56E-8
3 SGTC_1196 1588-0294 5.27 184.0 µM 9.12E-9 3 6.67E-8
4 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 5.04 63.6 µM 3.79E-8 22 2.36E-7
5 SGTC_3353 9151644 4.69 39.3 µM 2.71E-7 6 1.35E-6
6 SGTC_2792 7535235 4.36 81.8 µM 1.56E-6 fatty acid desaturase (OLE1) 25 6.36E-6
7 SGTC_1596 piperlongumine 4.35 63.0 µM 1.67E-6 8 6.73E-6
8 SGTC_1686 st019653 4.19 115.5 µM 3.79E-6 mitochondrial processes 7 1.39E-5
9 SGTC_1202 1988-0068 4.15 29.6 µM 4.52E-6 RNA processing & uracil transport 19 1.63E-5
10 SGTC_2363 9053361 3.97 176.0 µM 1.12E-5 Golgi 31 3.64E-5
11 SGTC_792 4534-1957 3.84 155.0 µM 2.03E-5 35 6.18E-5
12 SGTC_2913 7966556 3.81 36.6 µM 2.33E-5 60S ribosome export 13 6.98E-5
13 SGTC_1132 3456-3614 3.75 2.5 µM 2.99E-5 tubulin folding & SWR complex 62 8.70E-5
14 SGTC_1409 3909-8004 3.59 61.9 µM 6.24E-5 26 1.67E-4
15 SGTC_1692 fluoroquinolonic acid 3.57 71.0 µM 6.72E-5 10 1.78E-4
16 SGTC_2905 7799065 3.53 20.1 µM 8.09E-5 23 2.10E-4
17 SGTC_1562 morin hydrate 3.51 59.1 µM 8.56E-5 28 2.21E-4
18 SGTC_1811 st050069 3.51 61.5 µM 8.67E-5 9 2.24E-4
19 SGTC_341 1486-1430 3.45 230.0 µM 1.11E-4 35 2.79E-4
20 SGTC_3078 9116413 3.45 49.5 µM 1.12E-4 unfolded protein response 53 2.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.20E-26 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.142 1.21E-16 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.131 3.08E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.121 1.86E-12 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.121 1.92E-12 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.119 4.40E-12 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.115 2.29E-11 YLR267W_p BOP2_p hom Protein of unknown function
0.113 5.37E-11 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.110 1.93E-10 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.109 2.20E-10 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.108 3.81E-10 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.107 4.28E-10 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.107 4.41E-10 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.107 5.26E-10 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.104 1.31E-9 YGL136C MRM2 hom Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ