YER180C / ISC10

Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YER180C / ISC10

Click on Significant Values for Screen Details ID:SGTC_166|Compound:k072-0058|FD-Score:-4.26|P-value:1.24E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-5.36|P-value:5.57E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.71|P-value:6.08E-9 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.24|P-value:6.81E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.43|P-value:3.00E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.17|P-value:7.46E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.98|P-value:3.49E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.76|P-value:8.36E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.49|P-value:2.42E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.65|P-value:1.32E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.73|P-value:9.67E-5 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:4.17|P-value:1.54E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.44|P-value:3.32E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.34|P-value:7.29E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:5.77|P-value:4.17E-9 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.71|P-value:1.03E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.67|P-value:1.19E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.17|P-value:1.53E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.88|P-value:5.30E-5 ID:SGTC_1716|Compound:st033144|FD-Score:4.95|P-value:3.91E-7 ID:SGTC_1719|Compound:st032227|FD-Score:3.10|P-value:9.43E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.60|P-value:1.59E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.94|P-value:4.03E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.20|P-value:6.79E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.73|P-value:1.13E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.44|P-value:2.91E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.25|P-value:5.80E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.29|P-value:4.96E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.25|P-value:5.69E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.79|P-value:7.60E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.43|P-value:2.95E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.80|P-value:7.31E-5 ID:SGTC_2424|Compound:5537928|FD-Score:4.09|P-value:2.20E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.22|P-value:6.30E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.92|P-value:4.48E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.23|P-value:7.03E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.00|P-value:3.72E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.30|P-value:7.40E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.19|P-value:7.08E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.25|P-value:5.63E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.29|P-value:4.96E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.46|P-value:2.67E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.44|P-value:3.31E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.30|P-value:4.78E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.10|P-value:9.51E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.21|P-value:1.31E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.48|P-value:2.51E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.26|P-value:1.24E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-5.36|P-value:5.57E-8 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.71|P-value:6.08E-9 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.24|P-value:6.81E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.43|P-value:3.00E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.17|P-value:7.46E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:3.98|P-value:3.49E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.76|P-value:8.36E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.40|P-value:3.34E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.49|P-value:2.42E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.65|P-value:1.32E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.73|P-value:9.67E-5 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:4.17|P-value:1.54E-5 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.44|P-value:3.32E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.34|P-value:7.29E-6 ID:SGTC_1245|Compound:0418-0076|FD-Score:5.77|P-value:4.17E-9 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.71|P-value:1.03E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.67|P-value:1.19E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.17|P-value:1.53E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.88|P-value:5.30E-5 ID:SGTC_1716|Compound:st033144|FD-Score:4.95|P-value:3.91E-7 ID:SGTC_1719|Compound:st032227|FD-Score:3.10|P-value:9.43E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.60|P-value:1.59E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.94|P-value:4.03E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.20|P-value:6.79E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.73|P-value:1.13E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.44|P-value:2.91E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.25|P-value:5.80E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.29|P-value:4.96E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.25|P-value:5.69E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:3.79|P-value:7.60E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.43|P-value:2.95E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.80|P-value:7.31E-5 ID:SGTC_2424|Compound:5537928|FD-Score:4.09|P-value:2.20E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.22|P-value:6.30E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.92|P-value:4.48E-5 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.23|P-value:7.03E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-4.00|P-value:3.72E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.37|P-value:3.66E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-5.30|P-value:7.40E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.19|P-value:7.08E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.25|P-value:5.63E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.29|P-value:4.96E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.46|P-value:2.67E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.44|P-value:3.31E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.30|P-value:4.78E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.10|P-value:9.51E-4 ID:SGTC_3147|Compound:9097027|FD-Score:4.21|P-value:1.31E-5 ID:SGTC_3156|Compound:9099931|FD-Score:3.48|P-value:2.51E-4

Top fitness defect scores for YER180C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1245 0418-0076 5.77 17.2 µM 4.17E-9 ERG2 6 3.92E-9
2 SGTC_391 gliotoxin 5.71 8.3 µM 6.08E-9 26 5.73E-9
3 SGTC_1716 st033144 4.95 30.6 µM 3.91E-7 7 3.78E-7
4 SGTC_1240 0356-0016 4.34 42.1 µM 7.29E-6 mitochondrial response to ROS 28 7.20E-6
5 SGTC_3147 9097027 4.21 49.5 µM 1.31E-5 13 1.30E-5
6 SGTC_1600 coumarin 106 4.17 71.1 µM 1.53E-5 22 1.52E-5
7 SGTC_1102 cgs 12066b 4.17 26.1 µM 1.54E-5 endomembrane recycling 7 1.52E-5
8 SGTC_2424 5537928 4.09 59.2 µM 2.20E-5 34 2.19E-5
9 SGTC_793 0488-0545 3.98 106.0 µM 3.49E-5 14 3.48E-5
10 SGTC_1744 st037937 3.94 38.9 µM 4.03E-5 29 4.02E-5
11 SGTC_2496 diffractaic acid 3.92 79.8 µM 4.48E-5 20 4.47E-5
12 SGTC_1713 st033146 3.88 12.8 µM 5.30E-5 29 5.29E-5
13 SGTC_2319 6033012 3.80 152.6 µM 7.31E-5 tubulin folding & SWR complex 35 7.31E-5
14 SGTC_2236 dapsone 3.79 200.0 µM 7.60E-5 15 7.60E-5
15 SGTC_815 1582-0027 3.76 36.9 µM 8.36E-5 36 8.37E-5
16 SGTC_1087 pterostilbene 3.73 9.1 µM 9.67E-5 31 9.69E-5
17 SGTC_1350 1495-0454 3.71 146.0 µM 1.03E-4 38 1.04E-4
18 SGTC_1416 3966-0321 3.67 25.3 µM 1.19E-4 22 1.19E-4
19 SGTC_1074 carmofur 3.65 3.8 µM 1.32E-4 exosome 29 1.32E-4
20 SGTC_1740 st038286 3.60 13.2 µM 1.59E-4 37 1.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 5.21E-12 YGL059W PKP2 hom Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.105 1.20E-9 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.089 2.18E-7 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.088 3.39E-7 YLR144C ACF2 hom Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress
0.084 1.03E-6 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.083 1.71E-6 YFL049W SWP82 hom Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions
0.078 5.47E-6 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.078 5.92E-6 YPR162C ORC4 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.077 7.75E-6 YLR022C SDO1 het Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes
0.076 1.01E-5 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.076 1.17E-5 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.075 1.60E-5 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.074 1.57E-5 YOR188W MSB1 hom Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.074 1.87E-5 YLR116W MSL5 het Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
0.073 2.12E-5 YNL265C IST1 hom Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p