YER180C-A / SLO1

Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO

Zygosity: Homozygous strain
fixedexpanded
Profile for YER180C-A / SLO1

Click on Significant Values for Screen Details ID:SGTC_123|Compound:0083-0120|FD-Score:-3.48|P-value:5.58E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:11.10|P-value:1.50E-25 ID:SGTC_236|Compound:1509-0011|FD-Score:4.82|P-value:3.41E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.51|P-value:5.16E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.39|P-value:7.57E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:15.10|P-value:2.72E-45 ID:SGTC_320|Compound:4092-0846|FD-Score:4.88|P-value:2.61E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:4.56|P-value:1.05E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.94|P-value:1.15E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:5.02|P-value:1.44E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.31|P-value:2.80E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:5.28|P-value:4.16E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.89|P-value:2.40E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:4.50|P-value:1.34E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.62|P-value:3.76E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.41|P-value:1.98E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.87|P-value:1.48E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.57|P-value:4.31E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.40|P-value:7.61E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.09|P-value:6.82E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-4.62|P-value:7.71E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:3.68|P-value:3.02E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.93|P-value:1.59E-8 ID:SGTC_941|Compound:3237-0776|FD-Score:3.73|P-value:2.57E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.93|P-value:1.99E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.59|P-value:3.90E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.31|P-value:2.77E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.66|P-value:3.23E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.55|P-value:4.61E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.97|P-value:1.08E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.80|P-value:1.99E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.48|P-value:5.99E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.34|P-value:3.48E-15 ID:SGTC_1827|Compound:berberine|FD-Score:3.32|P-value:9.88E-4 ID:SGTC_1837|Compound:st055472|FD-Score:5.40|P-value:2.41E-7 ID:SGTC_1900|Compound:st060200|FD-Score:3.62|P-value:3.74E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.60|P-value:3.93E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.58|P-value:4.27E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.36|P-value:8.80E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:3.78E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.15|P-value:5.52E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.68|P-value:3.00E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:8.99E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.34|P-value:9.13E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.48|P-value:5.65E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:6.81|P-value:1.07E-10 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.16|P-value:5.18E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.54|P-value:4.58E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.36|P-value:8.74E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.05|P-value:8.47E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.36|P-value:8.74E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.00|P-value:9.62E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.53|P-value:4.99E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.90|P-value:1.33E-4 ID:SGTC_2862|Compound:9027634|FD-Score:5.76|P-value:3.91E-8 ID:SGTC_2882|Compound:9058044|FD-Score:4.09|P-value:6.97E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.70|P-value:5.87E-6 ID:SGTC_3032|Compound:9089427|FD-Score:3.76|P-value:2.30E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.45|P-value:1.66E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.37|P-value:8.52E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.35|P-value:9.08E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.97|P-value:1.06E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.80|P-value:3.76E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-4.78|P-value:3.86E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.39|P-value:7.43E-4 ID:SGTC_3211|Compound:9128781|FD-Score:6.04|P-value:8.81E-9 ID:SGTC_3236|Compound:9132701|FD-Score:3.79|P-value:2.07E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.48|P-value:5.58E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:11.10|P-value:1.50E-25 ID:SGTC_236|Compound:1509-0011|FD-Score:4.82|P-value:3.41E-6 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.51|P-value:5.16E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.39|P-value:7.57E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:15.10|P-value:2.72E-45 ID:SGTC_320|Compound:4092-0846|FD-Score:4.88|P-value:2.61E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:4.56|P-value:1.05E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.94|P-value:1.15E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:5.02|P-value:1.44E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.31|P-value:2.80E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:5.28|P-value:4.16E-7 ID:SGTC_516|Compound:3992-2719|FD-Score:-4.89|P-value:2.40E-6 ID:SGTC_565|Compound:1418-0001|FD-Score:4.50|P-value:1.34E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:3.62|P-value:3.76E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.41|P-value:1.98E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.87|P-value:1.48E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.57|P-value:4.31E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:3.40|P-value:7.61E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:4.09|P-value:6.82E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:-4.62|P-value:7.71E-6 ID:SGTC_807|Compound:1315-0151|FD-Score:3.68|P-value:3.02E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.93|P-value:1.59E-8 ID:SGTC_941|Compound:3237-0776|FD-Score:3.73|P-value:2.57E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-4.93|P-value:1.99E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.59|P-value:3.90E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.31|P-value:2.77E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.66|P-value:3.23E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.55|P-value:4.61E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.97|P-value:1.08E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.80|P-value:1.99E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.48|P-value:5.99E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.34|P-value:3.48E-15 ID:SGTC_1827|Compound:berberine|FD-Score:3.32|P-value:9.88E-4 ID:SGTC_1837|Compound:st055472|FD-Score:5.40|P-value:2.41E-7 ID:SGTC_1900|Compound:st060200|FD-Score:3.62|P-value:3.74E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.60|P-value:3.93E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.58|P-value:4.27E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.36|P-value:8.80E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:3.78E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.15|P-value:5.52E-5 ID:SGTC_2318|Compound:6029776|FD-Score:3.68|P-value:3.00E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:8.99E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.34|P-value:9.13E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.48|P-value:5.65E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:6.81|P-value:1.07E-10 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.16|P-value:5.18E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.54|P-value:4.58E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.36|P-value:8.74E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.05|P-value:8.47E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.36|P-value:8.74E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.00|P-value:9.62E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.53|P-value:4.99E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-3.90|P-value:1.33E-4 ID:SGTC_2862|Compound:9027634|FD-Score:5.76|P-value:3.91E-8 ID:SGTC_2882|Compound:9058044|FD-Score:4.09|P-value:6.97E-5 ID:SGTC_2896|Compound:9052656|FD-Score:4.70|P-value:5.87E-6 ID:SGTC_3032|Compound:9089427|FD-Score:3.76|P-value:2.30E-4 ID:SGTC_3037|Compound:9091026|FD-Score:4.45|P-value:1.66E-5 ID:SGTC_3108|Compound:9121785|FD-Score:3.37|P-value:8.52E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.35|P-value:9.08E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.97|P-value:1.06E-4 ID:SGTC_3199|Compound:9111318|FD-Score:4.80|P-value:3.76E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-4.78|P-value:3.86E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.39|P-value:7.43E-4 ID:SGTC_3211|Compound:9128781|FD-Score:6.04|P-value:8.81E-9 ID:SGTC_3236|Compound:9132701|FD-Score:3.79|P-value:2.07E-4

Top fitness defect scores for YER180C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_312 4092-0653 15.10 6.8 µM 2.72E-45 ergosterol depletion effects on membrane 3 1.18E-51
2 SGTC_207 4185-0010 11.10 4.5 µM 1.50E-25 endomembrane recycling 17 4.91E-29
3 SGTC_1750 st081859 8.34 2.4 µM 3.48E-15 endomembrane recycling 63 3.65E-17
4 SGTC_2558 carylophyllene oxide 6.81 100.0 µM 1.07E-10 1 5.00E-12
5 SGTC_2688 kanamycin b 6.05 96.7 µM 8.47E-9 calcium & mitochondrial duress 159 7.41E-10
6 SGTC_3211 9128781 6.04 49.5 µM 8.81E-9 19 7.76E-10
7 SGTC_825 1988-2224 5.93 89.6 µM 1.59E-8 cell wall signaling 15 1.52E-9
8 SGTC_2862 9027634 5.76 71.4 µM 3.91E-8 ERG2 12 4.27E-9
9 SGTC_1837 st055472 5.40 66.5 µM 2.41E-7 8 3.41E-8
10 SGTC_515 4092-1064 5.28 102.0 µM 4.16E-7 plasma membrane duress 33 6.35E-8
11 SGTC_427 1354-0053 5.02 47.3 µM 1.44E-6 4 2.62E-7
12 SGTC_320 4092-0846 4.88 5.3 µM 2.61E-6 ergosterol depletion effects on membrane 26 5.18E-7
13 SGTC_236 1509-0011 4.82 5.3 µM 3.41E-6 334 7.02E-7
14 SGTC_3199 9111318 4.80 49.5 µM 3.76E-6 10 7.85E-7
15 SGTC_2896 9052656 4.70 71.4 µM 5.87E-6 endomembrane recycling 68 1.31E-6
16 SGTC_334 1502-1024 4.56 68.5 µM 1.05E-5 5 2.53E-6
17 SGTC_565 1418-0001 4.50 44.5 µM 1.34E-5 9 3.35E-6
18 SGTC_3037 9091026 4.45 49.5 µM 1.66E-5 NEO1-PIK1 96 4.28E-6
19 SGTC_608 k048-0125 4.41 159.0 µM 1.98E-5 20 5.24E-6
20 SGTC_2564 betulinic acid 4.16 100.0 µM 5.18E-5 27 1.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.322 4.93E-82 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.320 1.42E-80 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.310 6.99E-76 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.308 1.05E-74 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.307 2.34E-74 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.269 7.61E-57 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.241 1.87E-45 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.240 4.36E-45 YDR166C SEC5 het Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
0.230 2.13E-41 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.226 5.70E-40 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.222 6.81E-39 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.197 1.34E-30 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.181 3.66E-26 YBR044C TCM62 hom Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.171 2.42E-23 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.168 1.41E-22 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress