YER181C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YER181C / YER181C

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.27|P-value:4.06E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.56|P-value:1.27E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.34|P-value:2.09E-8 ID:SGTC_377|Compound:3970-0964|FD-Score:3.03|P-value:9.11E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.81|P-value:3.79E-7 ID:SGTC_814|Compound:3342-0569|FD-Score:3.10|P-value:7.11E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.66|P-value:2.94E-9 ID:SGTC_965|Compound:1291-5240|FD-Score:4.65|P-value:8.97E-7 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.55|P-value:1.33E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.53|P-value:1.40E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.76|P-value:5.51E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.74|P-value:6.11E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.01|P-value:9.82E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.67|P-value:8.58E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.20|P-value:5.01E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.47|P-value:1.83E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.08|P-value:7.78E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.12|P-value:6.62E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.85|P-value:4.01E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.82|P-value:3.66E-7 ID:SGTC_2119|Compound:5528445|FD-Score:3.18|P-value:5.41E-4 ID:SGTC_2212|Compound:7123476|FD-Score:5.62|P-value:3.95E-9 ID:SGTC_2380|Compound:9035439|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.08|P-value:7.55E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.18|P-value:5.39E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.54|P-value:1.60E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.04|P-value:8.87E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.30|P-value:3.43E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.05|P-value:9.01E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.28|P-value:5.47E-6 ID:SGTC_3003|Compound:9075612|FD-Score:3.14|P-value:6.22E-4 ID:SGTC_3008|Compound:9078912|FD-Score:4.36|P-value:3.66E-6 ID:SGTC_3055|Compound:9094636|FD-Score:8.68|P-value:2.41E-19 ID:SGTC_3065|Compound:9113888|FD-Score:3.37|P-value:2.63E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.20|P-value:4.97E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.14|P-value:1.05E-5 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.27|P-value:4.06E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.56|P-value:1.27E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.34|P-value:2.09E-8 ID:SGTC_377|Compound:3970-0964|FD-Score:3.03|P-value:9.11E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:4.81|P-value:3.79E-7 ID:SGTC_814|Compound:3342-0569|FD-Score:3.10|P-value:7.11E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.66|P-value:2.94E-9 ID:SGTC_965|Compound:1291-5240|FD-Score:4.65|P-value:8.97E-7 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.55|P-value:1.33E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.53|P-value:1.40E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.76|P-value:5.51E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.74|P-value:6.11E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.01|P-value:9.82E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.67|P-value:8.58E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.20|P-value:5.01E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.47|P-value:1.83E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.39|P-value:2.47E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.08|P-value:7.78E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.21|P-value:4.89E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.12|P-value:6.62E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.85|P-value:4.01E-5 ID:SGTC_2065|Compound:5221596|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_2071|Compound:5230951|FD-Score:4.82|P-value:3.66E-7 ID:SGTC_2119|Compound:5528445|FD-Score:3.18|P-value:5.41E-4 ID:SGTC_2212|Compound:7123476|FD-Score:5.62|P-value:3.95E-9 ID:SGTC_2380|Compound:9035439|FD-Score:3.51|P-value:1.51E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.08|P-value:7.55E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.18|P-value:5.39E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-4.54|P-value:1.60E-6 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.04|P-value:8.87E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.30|P-value:3.43E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.05|P-value:9.01E-4 ID:SGTC_2907|Compound:7721985|FD-Score:4.28|P-value:5.47E-6 ID:SGTC_3003|Compound:9075612|FD-Score:3.14|P-value:6.22E-4 ID:SGTC_3008|Compound:9078912|FD-Score:4.36|P-value:3.66E-6 ID:SGTC_3055|Compound:9094636|FD-Score:8.68|P-value:2.41E-19 ID:SGTC_3065|Compound:9113888|FD-Score:3.37|P-value:2.63E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.20|P-value:4.97E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.14|P-value:1.05E-5

Top fitness defect scores for YER181C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3055 9094636 8.68 49.5 µM 2.41E-19 1 1.98E-18
2 SGTC_825 1988-2224 5.66 89.6 µM 2.94E-9 cell wall signaling 18 7.41E-9
3 SGTC_2212 7123476 5.62 200.0 µM 3.95E-9 1 9.79E-9
4 SGTC_344 k064-0035 5.34 6.4 µM 2.09E-8 60S ribosome export 8 4.77E-8
5 SGTC_2071 5230951 4.82 39.9 µM 3.66E-7 TSC3-RPN4 9 7.23E-7
6 SGTC_709 3807-1509 4.81 243.0 µM 3.79E-7 RSC complex & mRNA processing 6 7.46E-7
7 SGTC_965 1291-5240 4.65 308.0 µM 8.97E-7 16 1.69E-6
8 SGTC_3008 9078912 4.36 71.4 µM 3.66E-6 7 6.43E-6
9 SGTC_2907 7721985 4.28 69.9 µM 5.47E-6 14 9.43E-6
10 SGTC_3207 9114163 4.14 49.5 µM 1.05E-5 25 1.75E-5
11 SGTC_1153 4055-0057 3.76 267.0 µM 5.51E-5 32 8.45E-5
12 SGTC_1268 0828-0275 3.74 2.5 µM 6.11E-5 26 9.33E-5
13 SGTC_343 4130-2827 3.56 29.8 µM 1.27E-4 42 1.87E-4
14 SGTC_1106 tegaserod maleate 3.55 11.7 µM 1.33E-4 40 1.95E-4
15 SGTC_1147 3809-1045 3.53 12.3 µM 1.40E-4 36 2.05E-4
16 SGTC_2380 9035439 3.51 200.0 µM 1.51E-4 endomembrane recycling 43 2.20E-4
17 SGTC_1668 st014914 3.47 51.6 µM 1.83E-4 RPP1 & pyrimidine depletion 9 2.64E-4
18 SGTC_117 lucigenin 3.44 22.1 µM 2.02E-4 redox potentiating 113 2.91E-4
19 SGTC_1843 st055809 3.39 45.5 µM 2.47E-4 35 3.52E-4
20 SGTC_3065 9113888 3.37 49.5 µM 2.63E-4 44 3.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 6.76E-13 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.114 3.10E-11 YIL084C SDS3 hom Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
0.101 4.44E-9 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.100 6.27E-9 YML068W ITT1 hom Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.094 4.43E-8 YER034W YER034W hom Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress
0.092 8.81E-8 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.088 2.99E-7 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.086 5.41E-7 YOR140W SFL1 hom Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
0.081 2.94E-6 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.078 6.67E-6 YLR050C_p YLR050C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
0.077 8.01E-6 YLL037W_d YLL037W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
0.076 9.41E-6 YOR223W YOR223W hom Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3
0.075 1.47E-5 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.074 1.84E-5 YJL141C YAK1 hom Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
0.074 2.00E-5 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress