YER182W_p / FMP10

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YER182W / FMP10

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.10|P-value:7.08E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.18|P-value:5.24E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.49|P-value:1.91E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.72|P-value:6.19E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.60|P-value:1.07E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.80|P-value:4.65E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:5.76|P-value:1.47E-9 ID:SGTC_189|Compound:3970-0742|FD-Score:7.01|P-value:2.48E-13 ID:SGTC_359|Compound:0081-0058|FD-Score:4.19|P-value:8.07E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.41|P-value:2.28E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.68|P-value:7.20E-7 ID:SGTC_490|Compound:phenamil|FD-Score:3.14|P-value:6.09E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.18|P-value:5.17E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.39|P-value:2.34E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.50|P-value:1.56E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.01|P-value:9.62E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.22|P-value:4.46E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.58|P-value:1.10E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.02|P-value:9.13E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.88|P-value:6.79E-10 ID:SGTC_1068|Compound:loratadine|FD-Score:3.73|P-value:6.16E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.92|P-value:2.70E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.48|P-value:1.94E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.27|P-value:5.44E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.10|P-value:1.21E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.14|P-value:1.03E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.67|P-value:2.60E-9 ID:SGTC_1331|Compound:1472-0049|FD-Score:5.87|P-value:7.59E-10 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.36|P-value:3.64E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.09|P-value:7.48E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.88|P-value:3.29E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.10|P-value:7.06E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.82|P-value:4.21E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.14|P-value:6.15E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.03|P-value:9.18E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.00|P-value:9.98E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-3.13|P-value:6.01E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.12|P-value:6.41E-4 ID:SGTC_2271|Compound:7849410|FD-Score:4.34|P-value:3.89E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.87|P-value:3.45E-5 ID:SGTC_2353|Compound:9059630|FD-Score:4.66|P-value:8.09E-7 ID:SGTC_2360|Compound:9040895|FD-Score:5.03|P-value:1.13E-7 ID:SGTC_2361|Compound:9034121|FD-Score:-3.32|P-value:2.96E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.15|P-value:5.98E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.10|P-value:1.20E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.76|P-value:5.42E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.36|P-value:2.62E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.07|P-value:8.01E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.90|P-value:2.26E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-3.19|P-value:4.98E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.09|P-value:7.34E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.08|P-value:7.23E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.01|P-value:9.68E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.70|P-value:6.89E-5 ID:SGTC_3117|Compound:9124945|FD-Score:-3.29|P-value:3.36E-4 ID:SGTC_3123|Compound:9126162|FD-Score:6.34|P-value:3.25E-11 ID:SGTC_3127|Compound:9126946|FD-Score:-3.78|P-value:4.68E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.52|P-value:1.47E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.42|P-value:2.73E-6 ID:SGTC_3160|Compound:9100216|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.04|P-value:1.62E-5 ID:SGTC_3216|Compound:9129716|FD-Score:5.30|P-value:2.42E-8 ID:SGTC_38|Compound:0929-0051|FD-Score:3.10|P-value:7.08E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.18|P-value:5.24E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.49|P-value:1.91E-6 ID:SGTC_46|Compound:0329-0187a|FD-Score:-3.72|P-value:6.19E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.60|P-value:1.07E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.80|P-value:4.65E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:5.76|P-value:1.47E-9 ID:SGTC_189|Compound:3970-0742|FD-Score:7.01|P-value:2.48E-13 ID:SGTC_359|Compound:0081-0058|FD-Score:4.19|P-value:8.07E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.41|P-value:2.28E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.68|P-value:7.20E-7 ID:SGTC_490|Compound:phenamil|FD-Score:3.14|P-value:6.09E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.18|P-value:5.17E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.39|P-value:2.34E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.50|P-value:1.56E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.44|P-value:1.97E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.01|P-value:9.62E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-3.33|P-value:2.86E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.22|P-value:4.46E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.58|P-value:1.10E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.42|P-value:2.19E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.02|P-value:9.13E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.88|P-value:6.79E-10 ID:SGTC_1068|Compound:loratadine|FD-Score:3.73|P-value:6.16E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.92|P-value:2.70E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.48|P-value:1.94E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.27|P-value:5.44E-6 ID:SGTC_1222|Compound:0366-0074|FD-Score:4.10|P-value:1.21E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.14|P-value:1.03E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.67|P-value:2.60E-9 ID:SGTC_1331|Compound:1472-0049|FD-Score:5.87|P-value:7.59E-10 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.36|P-value:3.64E-6 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.09|P-value:7.48E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.88|P-value:3.29E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.10|P-value:7.06E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.82|P-value:4.21E-5 ID:SGTC_1998|Compound:st075797|FD-Score:3.14|P-value:6.15E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.03|P-value:9.18E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.00|P-value:9.98E-4 ID:SGTC_2237|Compound:6667747|FD-Score:-3.13|P-value:6.01E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.12|P-value:6.41E-4 ID:SGTC_2271|Compound:7849410|FD-Score:4.34|P-value:3.89E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.87|P-value:3.45E-5 ID:SGTC_2353|Compound:9059630|FD-Score:4.66|P-value:8.09E-7 ID:SGTC_2360|Compound:9040895|FD-Score:5.03|P-value:1.13E-7 ID:SGTC_2361|Compound:9034121|FD-Score:-3.32|P-value:2.96E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.15|P-value:5.98E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.10|P-value:1.20E-5 ID:SGTC_2646|Compound:retinol|FD-Score:3.76|P-value:5.42E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.36|P-value:2.62E-4 ID:SGTC_2818|Compound:7996756|FD-Score:3.07|P-value:8.01E-4 ID:SGTC_2831|Compound:7999036|FD-Score:4.90|P-value:2.26E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-3.19|P-value:4.98E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.09|P-value:7.34E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.08|P-value:7.23E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.01|P-value:9.68E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.70|P-value:6.89E-5 ID:SGTC_3117|Compound:9124945|FD-Score:-3.29|P-value:3.36E-4 ID:SGTC_3123|Compound:9126162|FD-Score:6.34|P-value:3.25E-11 ID:SGTC_3127|Compound:9126946|FD-Score:-3.78|P-value:4.68E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.52|P-value:1.47E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.42|P-value:2.73E-6 ID:SGTC_3160|Compound:9100216|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.04|P-value:1.62E-5 ID:SGTC_3216|Compound:9129716|FD-Score:5.30|P-value:2.42E-8

Top fitness defect scores for YER182W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_189 3970-0742 7.01 2.1 µM 2.48E-13 1 1.15E-12
2 SGTC_3123 9126162 6.34 49.5 µM 3.25E-11 2 1.14E-10
3 SGTC_1050 3232-1156 5.88 69.3 µM 6.79E-10 RSC complex & mRNA processing 4 2.01E-9
4 SGTC_1331 1472-0049 5.87 76.2 µM 7.59E-10 1 2.23E-9
5 SGTC_171 k064-0041 5.76 9.7 µM 1.47E-9 heme requiring 6 4.15E-9
6 SGTC_1326 1431-2094 5.67 10.8 µM 2.60E-9 tubulin folding & SWR complex 16 7.12E-9
7 SGTC_3216 9129716 5.30 49.5 µM 2.42E-8 RPP1 & pyrimidine depletion 10 5.83E-8
8 SGTC_2360 9040895 5.03 200.0 µM 1.13E-7 RPP1 & pyrimidine depletion 8 2.50E-7
9 SGTC_2831 7999036 4.90 19.5 µM 2.26E-7 19 4.81E-7
10 SGTC_453 enantio-paf c16 4.68 10.0 µM 7.20E-7 100 1.43E-6
11 SGTC_2353 9059630 4.66 146.7 µM 8.09E-7 11 1.60E-6
12 SGTC_42 0133-0086 4.49 60.6 µM 1.91E-6 13 3.60E-6
13 SGTC_1189 1431-2119 4.48 7.3 µM 1.94E-6 13 3.65E-6
14 SGTC_3141 9094609 4.42 49.5 µM 2.73E-6 iron homeostasis 28 5.04E-6
15 SGTC_1394 3474-0001 4.36 65.7 µM 3.64E-6 endomembrane recycling 30 6.62E-6
16 SGTC_2271 7849410 4.34 118.6 µM 3.89E-6 10 7.04E-6
17 SGTC_1213 1315-0166 4.27 115.0 µM 5.44E-6 21 9.67E-6
18 SGTC_359 0081-0058 4.19 15.9 µM 8.07E-6 60S ribosome export 36 1.40E-5
19 SGTC_1264 0783-0040 4.14 158.0 µM 1.03E-5 21 1.77E-5
20 SGTC_2394 5221648 4.10 200.0 µM 1.20E-5 20 2.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 5.81E-18 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.145 2.81E-17 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.69E-10 YPL217C BMS1 het GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
0.100 5.56E-9 YNL068C FKH2 hom Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication
0.093 7.72E-8 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.090 1.66E-7 YGL214W_d YGL214W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C
0.089 2.73E-7 YJL065C DLS1 hom Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication
0.088 3.40E-7 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.086 5.23E-7 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.36E-6 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.083 1.44E-6 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.082 1.79E-6 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.082 1.97E-6 YBR035C PDX3 hom Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
0.081 2.37E-6 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.079 4.36E-6 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription