HIPHOP chemogenomics database

YER183C / FAU1

5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis

Zygosity: Homozygous strain

fixedexpanded
Profile for YER183C / FAU1

Click on Significant Values for Screen Details

Top fitness defect scores for YER183C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3205	9113483	12.20	49.5 µM	3.18E-33		1	1.01E-34
2	SGTC_3207	9114163	6.72	49.5 µM	2.67E-11		1	9.14E-12
3	SGTC_1634	st006576	6.53	41.0 µM	9.03E-11	TSC3-RPN4	3	3.27E-11
4	SGTC_2319	6033012	6.28	152.6 µM	4.39E-10	tubulin folding & SWR complex	13	1.72E-10
5	SGTC_1600	coumarin 106	4.86	71.1 µM	1.05E-6		10	5.92E-7
6	SGTC_2322	7413319	4.67	38.2 µM	2.58E-6	ERAD & cell cycle	115	1.51E-6
7	SGTC_1348	1493-0373	4.67	93.8 µM	2.63E-6		9	1.54E-6
8	SGTC_1743	st037606	4.45	46.4 µM	7.09E-6		13	4.35E-6
9	SGTC_2207	7258803	4.31	200.0 µM	1.27E-5		6	7.98E-6
10	SGTC_1628	st004252	4.20	77.7 µM	2.09E-5		15	1.35E-5
11	SGTC_2240	6690706	4.19	185.9 µM	2.12E-5		13	1.37E-5
12	SGTC_1359	1582-0056	4.14	520.0 nM	2.65E-5		16	1.72E-5
13	SGTC_540	1187-0821	4.07	17.3 µM	3.53E-5		15	2.33E-5
14	SGTC_3203	9113543	4.07	49.5 µM	3.56E-5		28	2.35E-5
15	SGTC_1562	morin hydrate	4.03	59.1 µM	4.17E-5		16	2.78E-5
16	SGTC_2905	7799065	4.00	20.1 µM	4.67E-5		13	3.12E-5
17	SGTC_1528	arabinosylhypoxanthine	3.94	74.6 µM	5.96E-5		19	4.03E-5
18	SGTC_1113	artemisinin	3.87	1.2 µM	7.96E-5	heme biosynthesis & mitochondrial translocase	17	5.46E-5
19	SGTC_590	k048-0076	3.82	22.4 µM	9.69E-5	RSC & ERG11	14	6.70E-5
20	SGTC_1347	1493-0251	3.79	600.0 nM	1.08E-4	mitochondrial response to ROS	19	7.50E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.160	1.20E-20	YER001W	MNN1	hom	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.123	7.44E-13	YCL024W	KCC4	hom	Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.111	1.20E-10	YDL004W	ATP16	het	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.107	4.61E-10	YJL145W	SFH5	hom	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress
0.098	1.17E-8	YNL261W	ORC5	het	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.094	4.35E-8	YBR299W	MAL32	hom	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.094	4.80E-8	YJR047C	ANB1	hom	Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication
0.089	2.67E-7	YFR026C	ULI1	hom	Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.087	4.04E-7	YJL151C	SNA3	hom	Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
0.087	4.89E-7	YBL009W	ALK2	hom	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.083	1.48E-6	YPL236C	ENV7	hom	Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.083	1.58E-6	YDR275W	BSC2	hom	Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
0.081	2.38E-6	YFR056C_d	YFR056C_d	hom	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
0.080	3.20E-6	YER157W	COG3	het	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.080	3.48E-6	YKL192C	ACP1	het	Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p