YER183C / FAU1

5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YER183C / FAU1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.48|P-value:3.39E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.27|P-value:6.97E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.39|P-value:4.74E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:4.07|P-value:3.53E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:3.82|P-value:9.69E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.82|P-value:9.30E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.29|P-value:6.57E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.21|P-value:8.43E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.25|P-value:7.62E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.87|P-value:7.96E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.21|P-value:8.46E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.18|P-value:9.21E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.67|P-value:2.63E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.14|P-value:2.65E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.83|P-value:1.13E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.36|P-value:5.12E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.39|P-value:4.59E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.65|P-value:1.80E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.94|P-value:5.96E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.03|P-value:4.17E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-5.75|P-value:9.18E-9 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.86|P-value:1.05E-6 ID:SGTC_1628|Compound:st004252|FD-Score:4.20|P-value:2.09E-5 ID:SGTC_1634|Compound:st006576|FD-Score:6.53|P-value:9.03E-11 ID:SGTC_1743|Compound:st037606|FD-Score:4.45|P-value:7.09E-6 ID:SGTC_2117|Compound:5521686|FD-Score:-3.39|P-value:4.62E-4 ID:SGTC_2207|Compound:7258803|FD-Score:4.31|P-value:1.27E-5 ID:SGTC_2240|Compound:6690706|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_2319|Compound:6033012|FD-Score:6.28|P-value:4.39E-10 ID:SGTC_2322|Compound:7413319|FD-Score:4.67|P-value:2.58E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-4.42|P-value:7.57E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-4.06|P-value:3.53E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-5.18|P-value:2.00E-7 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.16|P-value:9.89E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.48|P-value:3.41E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.26|P-value:7.45E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.00|P-value:4.67E-5 ID:SGTC_3147|Compound:9097027|FD-Score:-4.13|P-value:2.64E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.05|P-value:3.75E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.58|P-value:2.38E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.39|P-value:4.50E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.07|P-value:3.56E-5 ID:SGTC_3205|Compound:9113483|FD-Score:12.20|P-value:3.18E-33 ID:SGTC_3207|Compound:9114163|FD-Score:6.72|P-value:2.67E-11 ID:SGTC_3212|Compound:9128307|FD-Score:-4.85|P-value:1.04E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-3.19|P-value:9.03E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.59|P-value:2.34E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:3.48|P-value:3.39E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.27|P-value:6.97E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.39|P-value:4.74E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:4.07|P-value:3.53E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:3.82|P-value:9.69E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.82|P-value:9.30E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:3.29|P-value:6.57E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.21|P-value:8.43E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.25|P-value:7.62E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.87|P-value:7.96E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.21|P-value:8.46E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.18|P-value:9.21E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.79|P-value:1.08E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.67|P-value:2.63E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.14|P-value:2.65E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.83|P-value:1.13E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.36|P-value:5.12E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.39|P-value:4.59E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.65|P-value:1.80E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.94|P-value:5.96E-5 ID:SGTC_1562|Compound:morin hydrate|FD-Score:4.03|P-value:4.17E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-5.75|P-value:9.18E-9 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.86|P-value:1.05E-6 ID:SGTC_1628|Compound:st004252|FD-Score:4.20|P-value:2.09E-5 ID:SGTC_1634|Compound:st006576|FD-Score:6.53|P-value:9.03E-11 ID:SGTC_1743|Compound:st037606|FD-Score:4.45|P-value:7.09E-6 ID:SGTC_2117|Compound:5521686|FD-Score:-3.39|P-value:4.62E-4 ID:SGTC_2207|Compound:7258803|FD-Score:4.31|P-value:1.27E-5 ID:SGTC_2240|Compound:6690706|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_2319|Compound:6033012|FD-Score:6.28|P-value:4.39E-10 ID:SGTC_2322|Compound:7413319|FD-Score:4.67|P-value:2.58E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-4.42|P-value:7.57E-6 ID:SGTC_2336|Compound:9001819|FD-Score:-4.06|P-value:3.53E-5 ID:SGTC_2339|Compound:9000433|FD-Score:-5.18|P-value:2.00E-7 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.16|P-value:9.89E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.48|P-value:3.41E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.26|P-value:7.45E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.50|P-value:3.22E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.00|P-value:4.67E-5 ID:SGTC_3147|Compound:9097027|FD-Score:-4.13|P-value:2.64E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.05|P-value:3.75E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.58|P-value:2.38E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.39|P-value:4.50E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.07|P-value:3.56E-5 ID:SGTC_3205|Compound:9113483|FD-Score:12.20|P-value:3.18E-33 ID:SGTC_3207|Compound:9114163|FD-Score:6.72|P-value:2.67E-11 ID:SGTC_3212|Compound:9128307|FD-Score:-4.85|P-value:1.04E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-3.19|P-value:9.03E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.59|P-value:2.34E-4

Top fitness defect scores for YER183C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3205 9113483 12.20 49.5 µM 3.18E-33 1 1.01E-34
2 SGTC_3207 9114163 6.72 49.5 µM 2.67E-11 1 9.14E-12
3 SGTC_1634 st006576 6.53 41.0 µM 9.03E-11 TSC3-RPN4 3 3.27E-11
4 SGTC_2319 6033012 6.28 152.6 µM 4.39E-10 tubulin folding & SWR complex 13 1.72E-10
5 SGTC_1600 coumarin 106 4.86 71.1 µM 1.05E-6 10 5.92E-7
6 SGTC_2322 7413319 4.67 38.2 µM 2.58E-6 ERAD & cell cycle 115 1.51E-6
7 SGTC_1348 1493-0373 4.67 93.8 µM 2.63E-6 9 1.54E-6
8 SGTC_1743 st037606 4.45 46.4 µM 7.09E-6 13 4.35E-6
9 SGTC_2207 7258803 4.31 200.0 µM 1.27E-5 6 7.98E-6
10 SGTC_1628 st004252 4.20 77.7 µM 2.09E-5 15 1.35E-5
11 SGTC_2240 6690706 4.19 185.9 µM 2.12E-5 13 1.37E-5
12 SGTC_1359 1582-0056 4.14 520.0 nM 2.65E-5 16 1.72E-5
13 SGTC_540 1187-0821 4.07 17.3 µM 3.53E-5 15 2.33E-5
14 SGTC_3203 9113543 4.07 49.5 µM 3.56E-5 28 2.35E-5
15 SGTC_1562 morin hydrate 4.03 59.1 µM 4.17E-5 16 2.78E-5
16 SGTC_2905 7799065 4.00 20.1 µM 4.67E-5 13 3.12E-5
17 SGTC_1528 arabinosylhypoxanthine 3.94 74.6 µM 5.96E-5 19 4.03E-5
18 SGTC_1113 artemisinin 3.87 1.2 µM 7.96E-5 heme biosynthesis & mitochondrial translocase 17 5.46E-5
19 SGTC_590 k048-0076 3.82 22.4 µM 9.69E-5 RSC & ERG11 14 6.70E-5
20 SGTC_1347 1493-0251 3.79 600.0 nM 1.08E-4 mitochondrial response to ROS 19 7.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.20E-20 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.123 7.44E-13 YCL024W KCC4 hom Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication
0.111 1.20E-10 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.107 4.61E-10 YJL145W SFH5 hom Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress
0.098 1.17E-8 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.094 4.35E-8 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.094 4.80E-8 YJR047C ANB1 hom Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication
0.089 2.67E-7 YFR026C ULI1 hom Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response
0.087 4.04E-7 YJL151C SNA3 hom Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles
0.087 4.89E-7 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.083 1.48E-6 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.083 1.58E-6 YDR275W BSC2 hom Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
0.081 2.38E-6 YFR056C_d YFR056C_d hom Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
0.080 3.20E-6 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.080 3.48E-6 YKL192C ACP1 het Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p