YER186C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YER186C / YER186C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.51|P-value:3.02E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:3.20|P-value:7.99E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.57|P-value:2.20E-4 ID:SGTC_406|Compound:estrone|FD-Score:5.90|P-value:3.39E-9 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.89|P-value:6.33E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.45|P-value:6.00E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.52|P-value:5.46E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:3.33|P-value:5.10E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.34|P-value:4.97E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.97|P-value:4.60E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.35|P-value:4.86E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.42|P-value:3.76E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:4.46|P-value:5.75E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:5.69|P-value:1.12E-8 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.50|P-value:3.36E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.68|P-value:1.48E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:5.05|P-value:3.41E-7 ID:SGTC_992|Compound:3909-8734|FD-Score:4.42|P-value:6.76E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:4.33|P-value:1.01E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.18|P-value:8.48E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-3.55|P-value:2.82E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.35|P-value:7.47E-8 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.63|P-value:1.79E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-6.99|P-value:4.90E-12 ID:SGTC_1570|Compound:verbenone|FD-Score:-5.32|P-value:1.13E-7 ID:SGTC_1612|Compound:st002233|FD-Score:3.74|P-value:1.14E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:5.73|P-value:9.17E-9 ID:SGTC_1637|Compound:st007924|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.17|P-value:8.77E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.33|P-value:5.22E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.02|P-value:3.81E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.25|P-value:6.79E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.55|P-value:3.86E-6 ID:SGTC_1962|Compound:st076595|FD-Score:3.14|P-value:9.84E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.25|P-value:6.86E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.13|P-value:2.44E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.63|P-value:1.78E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.07|P-value:3.84E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-5.80|P-value:8.05E-9 ID:SGTC_2338|Compound:7999974|FD-Score:4.24|P-value:1.54E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.75|P-value:7.96E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.15|P-value:2.19E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.79|P-value:9.54E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.19|P-value:8.29E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.12|P-value:2.47E-5 ID:SGTC_2683|Compound:piperine|FD-Score:3.32|P-value:5.42E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.22|P-value:7.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.77|P-value:1.38E-6 ID:SGTC_2785|Compound:7756463|FD-Score:3.83|P-value:8.32E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.40|P-value:4.74E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.25|P-value:6.70E-4 ID:SGTC_2892|Compound:9047358|FD-Score:5.17|P-value:1.89E-7 ID:SGTC_2912|Compound:7964298|FD-Score:-3.89|P-value:7.87E-5 ID:SGTC_3085|Compound:9117376|FD-Score:4.48|P-value:5.28E-6 ID:SGTC_3154|Compound:9100113|FD-Score:3.14|P-value:9.83E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.38|P-value:5.24E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.16|P-value:9.24E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.56|P-value:2.75E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.40|P-value:4.06E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:5.51|P-value:3.02E-8 ID:SGTC_347|Compound:4534-1311|FD-Score:3.20|P-value:7.99E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.57|P-value:2.20E-4 ID:SGTC_406|Compound:estrone|FD-Score:5.90|P-value:3.39E-9 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.89|P-value:6.33E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.45|P-value:6.00E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.52|P-value:5.46E-6 ID:SGTC_591|Compound:4299-0174|FD-Score:3.33|P-value:5.10E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:3.34|P-value:4.97E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.97|P-value:4.60E-5 ID:SGTC_813|Compound:k007-0158|FD-Score:3.35|P-value:4.86E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.42|P-value:3.76E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:4.46|P-value:5.75E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:5.69|P-value:1.12E-8 ID:SGTC_828|Compound:2074-0507|FD-Score:-3.50|P-value:3.36E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.68|P-value:1.48E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:5.05|P-value:3.41E-7 ID:SGTC_992|Compound:3909-8734|FD-Score:4.42|P-value:6.76E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:4.33|P-value:1.01E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.18|P-value:8.48E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-3.55|P-value:2.82E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.35|P-value:7.47E-8 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.44|P-value:3.53E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.63|P-value:1.79E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-6.99|P-value:4.90E-12 ID:SGTC_1570|Compound:verbenone|FD-Score:-5.32|P-value:1.13E-7 ID:SGTC_1612|Compound:st002233|FD-Score:3.74|P-value:1.14E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:5.73|P-value:9.17E-9 ID:SGTC_1637|Compound:st007924|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.17|P-value:8.77E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.33|P-value:5.22E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.02|P-value:3.81E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.25|P-value:6.79E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.55|P-value:3.86E-6 ID:SGTC_1962|Compound:st076595|FD-Score:3.14|P-value:9.84E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.25|P-value:6.86E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.67|P-value:1.49E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.13|P-value:2.44E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.63|P-value:1.78E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.07|P-value:3.84E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-5.80|P-value:8.05E-9 ID:SGTC_2338|Compound:7999974|FD-Score:4.24|P-value:1.54E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.75|P-value:7.96E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.15|P-value:2.19E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.79|P-value:9.54E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.19|P-value:8.29E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.12|P-value:2.47E-5 ID:SGTC_2683|Compound:piperine|FD-Score:3.32|P-value:5.42E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.22|P-value:7.63E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.77|P-value:1.38E-6 ID:SGTC_2785|Compound:7756463|FD-Score:3.83|P-value:8.32E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.40|P-value:4.74E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.25|P-value:6.70E-4 ID:SGTC_2892|Compound:9047358|FD-Score:5.17|P-value:1.89E-7 ID:SGTC_2912|Compound:7964298|FD-Score:-3.89|P-value:7.87E-5 ID:SGTC_3085|Compound:9117376|FD-Score:4.48|P-value:5.28E-6 ID:SGTC_3154|Compound:9100113|FD-Score:3.14|P-value:9.83E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.38|P-value:5.24E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.16|P-value:9.24E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.56|P-value:2.75E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.40|P-value:4.06E-4

Top fitness defect scores for YER186C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_406 estrone 5.90 100.0 µM 3.39E-9 1 1.80E-9
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.75 3.7 µM 7.96E-9 15 4.37E-9
3 SGTC_1631 benzylvanillin 5.73 81.9 µM 9.17E-9 Golgi 6 5.06E-9
4 SGTC_824 1304-0008 5.69 100.0 µM 1.12E-8 DNA damage response 9 6.24E-9
5 SGTC_344 k064-0035 5.51 6.4 µM 3.02E-8 60S ribosome export 3 1.75E-8
6 SGTC_1187 1391-0724 5.35 117.0 µM 7.47E-8 amide catabolism 5 4.48E-8
7 SGTC_2892 9047358 5.17 58.4 µM 1.89E-7 2 1.18E-7
8 SGTC_880 0833-0487 5.05 87.2 µM 3.41E-7 mitochondrial processes 4 2.17E-7
9 SGTC_2781 5567276 4.77 71.4 µM 1.38E-6 25 9.26E-7
10 SGTC_1928 4'-methoxychalcone 4.55 40.3 µM 3.86E-6 4 2.70E-6
11 SGTC_3085 9117376 4.48 49.5 µM 5.28E-6 4 3.74E-6
12 SGTC_819 1013-0258 4.46 27.7 µM 5.75E-6 25 4.08E-6
13 SGTC_413 propylparaben 4.45 100.0 µM 6.00E-6 amide catabolism 12 4.27E-6
14 SGTC_992 3909-8734 4.42 162.0 µM 6.76E-6 8 4.83E-6
15 SGTC_994 3910-0338 4.33 138.0 µM 1.01E-5 calcium & mitochondrial duress 35 7.30E-6
16 SGTC_2338 7999974 4.24 200.0 µM 1.54E-5 15 1.14E-5
17 SGTC_2553 4-methylesculetin 4.15 85.1 µM 2.19E-5 17 1.64E-5
18 SGTC_2059 5238311 4.13 157.0 µM 2.44E-5 17 1.83E-5
19 SGTC_2578 7,8-dihydroxyflavone 4.12 64.4 µM 2.47E-5 29 1.86E-5
20 SGTC_1921 5740136 4.02 50.0 µM 3.81E-5 TRP & mitochondrial translation 54 2.91E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.80E-10 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.107 4.84E-10 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.104 1.30E-9 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.101 4.28E-9 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.100 6.29E-9 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.098 1.39E-8 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.093 7.08E-8 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.086 6.87E-7 YOR372C NDD1 het Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
0.086 6.94E-7 YHR014W SPO13 hom Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
0.086 6.97E-7 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.085 9.39E-7 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.083 1.31E-6 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.083 1.32E-6 YKR025W RPC37 het RNA polymerase III subunit C37
0.083 1.41E-6 YBR005W RCR1 hom Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication
0.082 1.71E-6 YLR412C-A_p YLR412C-A_p hom Putative protein of unknown function