YER187W_p

Putative protein of unknown function; induced in respiratory-deficient cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YER187W / YER187W

Click on Significant Values for Screen Details ID:SGTC_269|Compound:exalamide|FD-Score:-3.22|P-value:2.47E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.03|P-value:5.26E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.75|P-value:2.34E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:4.20|P-value:2.63E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:2.97|P-value:6.29E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:4.77|P-value:1.14E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:3.31|P-value:1.65E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.09|P-value:3.91E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:3.16|P-value:2.94E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:2.98|P-value:6.06E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.65|P-value:3.66E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:3.91|P-value:1.07E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.14|P-value:3.20E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.51|P-value:6.80E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:2.85|P-value:9.87E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:2.89|P-value:8.54E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.44|P-value:9.53E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.09|P-value:3.94E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.90|P-value:1.16E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.35|P-value:1.37E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.01|P-value:5.33E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-5.97|P-value:5.25E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.55|P-value:6.22E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.95|P-value:6.83E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.56|P-value:5.44E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.21|P-value:2.56E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.04|P-value:6.16E-6 ID:SGTC_1736|Compound:st036774|FD-Score:5.53|P-value:9.80E-10 ID:SGTC_2018|Compound:5133068|FD-Score:-3.13|P-value:3.56E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.52|P-value:7.06E-5 ID:SGTC_2075|Compound:5212009|FD-Score:4.51|P-value:4.84E-7 ID:SGTC_2111|Compound:5486399|FD-Score:3.75|P-value:2.38E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.88|P-value:1.28E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.32|P-value:1.53E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.29|P-value:1.64E-6 ID:SGTC_2456|Compound:5770359|FD-Score:3.04|P-value:4.75E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.00|P-value:5.63E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:5.03E-5 ID:SGTC_2641|Compound:levomentholum|FD-Score:6.41|P-value:1.77E-12 ID:SGTC_2669|Compound:eugenol|FD-Score:3.80|P-value:1.88E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:-3.41|P-value:1.14E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-2.91|P-value:8.31E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.15|P-value:3.11E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-2.86|P-value:9.88E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-2.94|P-value:7.41E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.73|P-value:2.54E-5 ID:SGTC_3041|Compound:9091929|FD-Score:5.56|P-value:8.31E-10 ID:SGTC_3071|Compound:9117417|FD-Score:3.15|P-value:3.11E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.54|P-value:6.11E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-3.22|P-value:2.47E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.03|P-value:5.26E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.75|P-value:2.34E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:4.20|P-value:2.63E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:2.97|P-value:6.29E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:4.77|P-value:1.14E-7 ID:SGTC_590|Compound:k048-0076|FD-Score:3.31|P-value:1.65E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.00|P-value:5.64E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.09|P-value:3.91E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:3.16|P-value:2.94E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:2.98|P-value:6.06E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.65|P-value:3.66E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:3.91|P-value:1.07E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.14|P-value:3.20E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.51|P-value:6.80E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:2.85|P-value:9.87E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:2.89|P-value:8.54E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.44|P-value:9.53E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.09|P-value:3.94E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.90|P-value:1.16E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.35|P-value:1.37E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.01|P-value:5.33E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-5.97|P-value:5.25E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.55|P-value:6.22E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.95|P-value:6.83E-4 ID:SGTC_1687|Compound:st020778|FD-Score:3.56|P-value:5.44E-5 ID:SGTC_1729|Compound:st035615|FD-Score:-3.21|P-value:2.56E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-4.04|P-value:6.16E-6 ID:SGTC_1736|Compound:st036774|FD-Score:5.53|P-value:9.80E-10 ID:SGTC_2018|Compound:5133068|FD-Score:-3.13|P-value:3.56E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.52|P-value:7.06E-5 ID:SGTC_2075|Compound:5212009|FD-Score:4.51|P-value:4.84E-7 ID:SGTC_2111|Compound:5486399|FD-Score:3.75|P-value:2.38E-5 ID:SGTC_2328|Compound:6201408|FD-Score:3.88|P-value:1.28E-5 ID:SGTC_2399|Compound:5884133|FD-Score:3.32|P-value:1.53E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.29|P-value:1.64E-6 ID:SGTC_2456|Compound:5770359|FD-Score:3.04|P-value:4.75E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.00|P-value:5.63E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:5.03E-5 ID:SGTC_2641|Compound:levomentholum|FD-Score:6.41|P-value:1.77E-12 ID:SGTC_2669|Compound:eugenol|FD-Score:3.80|P-value:1.88E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:-3.41|P-value:1.14E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-2.91|P-value:8.31E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.15|P-value:3.11E-4 ID:SGTC_2811|Compound:7967822|FD-Score:-2.86|P-value:9.88E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-2.94|P-value:7.41E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.73|P-value:2.54E-5 ID:SGTC_3041|Compound:9091929|FD-Score:5.56|P-value:8.31E-10 ID:SGTC_3071|Compound:9117417|FD-Score:3.15|P-value:3.11E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.54|P-value:6.11E-5

Top fitness defect scores for YER187W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2641 levomentholum 6.41 100.0 µM 1.77E-12 1 7.24E-11
2 SGTC_3041 9091929 5.56 49.5 µM 8.31E-10 redox potentiating 6 1.38E-8
3 SGTC_1736 st036774 5.53 51.0 µM 9.80E-10 10 1.59E-8
4 SGTC_570 0987-0065 4.77 62.6 µM 1.14E-7 60S ribosome export 4 9.27E-7
5 SGTC_2075 5212009 4.51 200.0 µM 4.84E-7 4 3.20E-6
6 SGTC_2426 5582046 4.29 32.2 µM 1.64E-6 19 9.09E-6
7 SGTC_424 splitomicin 4.20 100.0 mM 2.63E-6 15 1.36E-5
8 SGTC_789 1309-1135 3.91 70.6 µM 1.07E-5 ERG2 29 4.54E-5
9 SGTC_1068 loratadine 3.90 26.9 µM 1.16E-5 26 4.86E-5
10 SGTC_2328 6201408 3.88 200.0 µM 1.28E-5 21 5.28E-5
11 SGTC_2669 eugenol 3.80 100.0 µM 1.88E-5 13 7.34E-5
12 SGTC_421 streptovitacin 3.75 30.0 mM 2.34E-5 28 8.88E-5
13 SGTC_2111 5486399 3.75 200.0 µM 2.38E-5 57 9.00E-5
14 SGTC_3001 9076041 3.73 71.4 µM 2.54E-5 19 9.52E-5
15 SGTC_776 4476-4378 3.65 112.0 µM 3.66E-5 ERG2 26 1.30E-4
16 SGTC_2574 2',4'-dihydroxychalcone 3.58 14.6 µM 5.03E-5 33 1.71E-4
17 SGTC_1687 st020778 3.56 55.4 µM 5.44E-5 194 1.83E-4
18 SGTC_3207 9114163 3.54 49.5 µM 6.11E-5 44 2.02E-4
19 SGTC_813 k007-0158 3.51 173.0 µM 6.80E-5 fatty acid desaturase (OLE1) 64 2.21E-4
20 SGTC_993 3909-8757 3.44 62.7 µM 9.53E-5 38 2.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 9.36E-10 YML059C NTE1 hom Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
0.104 1.66E-9 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 1.05E-8 YLR194C YLR194C hom Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
0.092 8.09E-8 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.091 1.18E-7 YBL099W ATP1 hom Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.084 1.01E-6 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.080 3.20E-6 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.080 3.84E-6 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.076 1.05E-5 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.075 1.33E-5 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.075 1.36E-5 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.075 1.46E-5 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.074 1.81E-5 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.074 1.86E-5 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.072 3.10E-5 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency