YER188W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER188W / YER188W

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.43|P-value:4.99E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.08|P-value:6.11E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-4.04|P-value:1.36E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:3.33|P-value:7.19E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.91|P-value:7.99E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:4.92|P-value:8.68E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.15|P-value:4.77E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:6.90|P-value:6.34E-12 ID:SGTC_880|Compound:0833-0487|FD-Score:4.84|P-value:1.29E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.66|P-value:2.15E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.70|P-value:2.53E-6 ID:SGTC_1296|Compound:1068-0102|FD-Score:-2.94|P-value:9.85E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.75|P-value:1.55E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-4.35|P-value:3.36E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.64|P-value:2.32E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.07|P-value:4.12E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-4.38|P-value:2.92E-6 ID:SGTC_1651|Compound:st011928|FD-Score:3.28|P-value:8.49E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.09|P-value:3.83E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.52|P-value:5.72E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.49|P-value:4.03E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.83|P-value:1.31E-6 ID:SGTC_2049|Compound:5262831|FD-Score:4.42|P-value:9.17E-6 ID:SGTC_2061|Compound:5245884|FD-Score:-3.43|P-value:1.70E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.91|P-value:2.39E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.30|P-value:7.89E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.40|P-value:5.47E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.27|P-value:8.75E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.28|P-value:8.46E-4 ID:SGTC_2372|Compound:9071633|FD-Score:7.12|P-value:1.36E-12 ID:SGTC_2381|Compound:9035592|FD-Score:3.82|P-value:1.17E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.36|P-value:6.43E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.93|P-value:7.41E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.09|P-value:5.98E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.01|P-value:5.35E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_2714|Compound:st079313|FD-Score:4.10|P-value:3.69E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.67|P-value:6.58E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.83|P-value:1.04E-11 ID:SGTC_2823|Compound:7987624|FD-Score:3.40|P-value:5.62E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.93|P-value:7.60E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.43|P-value:4.99E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.08|P-value:6.11E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-4.04|P-value:1.36E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:3.33|P-value:7.19E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.91|P-value:7.99E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:4.92|P-value:8.68E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.15|P-value:4.77E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:6.90|P-value:6.34E-12 ID:SGTC_880|Compound:0833-0487|FD-Score:4.84|P-value:1.29E-6 ID:SGTC_1025|Compound:k007-0731|FD-Score:3.66|P-value:2.15E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.70|P-value:2.53E-6 ID:SGTC_1296|Compound:1068-0102|FD-Score:-2.94|P-value:9.85E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.75|P-value:1.55E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:-4.35|P-value:3.36E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.64|P-value:2.32E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:4.07|P-value:4.12E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-4.38|P-value:2.92E-6 ID:SGTC_1651|Compound:st011928|FD-Score:3.28|P-value:8.49E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.09|P-value:3.83E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.52|P-value:5.72E-6 ID:SGTC_1865|Compound:st057639|FD-Score:3.49|P-value:4.03E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.83|P-value:1.31E-6 ID:SGTC_2049|Compound:5262831|FD-Score:4.42|P-value:9.17E-6 ID:SGTC_2061|Compound:5245884|FD-Score:-3.43|P-value:1.70E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.91|P-value:2.39E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.30|P-value:7.89E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.40|P-value:5.47E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.27|P-value:8.75E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.28|P-value:8.46E-4 ID:SGTC_2372|Compound:9071633|FD-Score:7.12|P-value:1.36E-12 ID:SGTC_2381|Compound:9035592|FD-Score:3.82|P-value:1.17E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.36|P-value:6.43E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.93|P-value:7.41E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.09|P-value:5.98E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.01|P-value:5.35E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_2714|Compound:st079313|FD-Score:4.10|P-value:3.69E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.67|P-value:6.58E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:6.83|P-value:1.04E-11 ID:SGTC_2823|Compound:7987624|FD-Score:3.40|P-value:5.62E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.93|P-value:7.60E-5

Top fitness defect scores for YER188W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2372 9071633 7.12 200.0 µM 1.36E-12 2 5.28E-13
2 SGTC_873 0591-4978 6.90 488.0 µM 6.34E-12 1 2.53E-12
3 SGTC_2759 disulfiram 6.83 3.4 µM 1.04E-11 3 4.18E-12
4 SGTC_866 0495-0101 4.92 262.0 µM 8.68E-7 60S ribosome export 6 4.38E-7
5 SGTC_880 0833-0487 4.84 87.2 µM 1.29E-6 mitochondrial processes 5 6.57E-7
6 SGTC_2019 4016004 4.83 108.0 µM 1.31E-6 9 6.67E-7
7 SGTC_1077 5-fluorocytosine 4.70 377.0 nM 2.53E-6 exosome 7 1.31E-6
8 SGTC_1824 st053723 4.52 68.6 µM 5.72E-6 19 3.02E-6
9 SGTC_2049 5262831 4.42 67.2 µM 9.17E-6 18 4.91E-6
10 SGTC_2714 st079313 4.10 56.9 µM 3.69E-5 7 2.06E-5
11 SGTC_1655 st012546 4.09 55.1 µM 3.83E-5 29 2.13E-5
12 SGTC_1421 4029-0249 4.07 71.4 µM 4.12E-5 15 2.30E-5
13 SGTC_2684 capsaicin 4.01 100.0 µM 5.35E-5 17 3.01E-5
14 SGTC_2386 9075165 3.93 157.4 µM 7.41E-5 8 4.21E-5
15 SGTC_3289 9119912 3.93 71.4 µM 7.60E-5 16 4.32E-5
16 SGTC_776 4476-4378 3.91 112.0 µM 7.99E-5 ERG2 21 4.56E-5
17 SGTC_2381 9035592 3.82 200.0 µM 1.17E-4 21 6.72E-5
18 SGTC_1310 1188-0297 3.75 994.0 nM 1.55E-4 azole & statin 36 9.01E-5
19 SGTC_1025 k007-0731 3.66 70.0 µM 2.15E-4 19 1.26E-4
20 SGTC_1414 3917-0015 3.64 5.4 µM 2.32E-4 15 1.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.12E-11 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.095 3.15E-8 YOR284W HUA2 hom Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
0.089 2.65E-7 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.088 3.24E-7 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.086 6.45E-7 YDL031W DBP10 het Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
0.083 1.69E-6 YOR374W ALD4 hom Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
0.079 4.21E-6 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.078 5.71E-6 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.078 6.94E-6 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.073 2.42E-5 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.070 4.37E-5 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
0.070 4.96E-5 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.067 9.57E-5 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.066 1.19E-4 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.066 1.43E-4 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence