YFL007W / BLM10

Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL007W / BLM10

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.24|P-value:8.43E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.14|P-value:6.20E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.09|P-value:8.76E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:3.17E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.17|P-value:6.68E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:-3.08|P-value:7.71E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.37|P-value:4.50E-6 ID:SGTC_300|Compound:r073-0011|FD-Score:3.11|P-value:8.20E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.06|P-value:9.62E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.76|P-value:6.95E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:3.25|P-value:4.96E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.07|P-value:9.53E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.26|P-value:4.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.10|P-value:8.40E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.07|P-value:7.85E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-4.11|P-value:1.21E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.76|P-value:6.83E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.49|P-value:2.55E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.39|P-value:2.94E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.23|P-value:8.86E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.11|P-value:8.27E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.49|P-value:2.06E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.15|P-value:1.29E-5 ID:SGTC_1732|Compound:st034308|FD-Score:3.12|P-value:7.82E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.76|P-value:6.74E-7 ID:SGTC_1854|Compound:st056233|FD-Score:5.29|P-value:3.81E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.81|P-value:5.70E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.73|P-value:7.77E-5 ID:SGTC_1882|Compound:5615643|FD-Score:6.74|P-value:3.59E-12 ID:SGTC_1977|Compound:st070720|FD-Score:3.90|P-value:3.79E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.92|P-value:2.80E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.33|P-value:3.72E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.51|P-value:1.56E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.86|P-value:3.11E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.07|P-value:9.55E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.39|P-value:2.50E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.02|P-value:9.32E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.14|P-value:8.96E-8 ID:SGTC_2698|Compound:st077697|FD-Score:3.65|P-value:1.07E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.81|P-value:4.61E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-6.24|P-value:8.24E-11 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.38|P-value:2.59E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-5.00|P-value:1.44E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.79|P-value:2.03E-9 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.85|P-value:3.85E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-4.01|P-value:1.91E-5 ID:SGTC_2909|Compound:7941780|FD-Score:3.38|P-value:3.09E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.25|P-value:4.99E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.26|P-value:4.86E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.20|P-value:6.00E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.23|P-value:5.44E-4 ID:SGTC_3171|Compound:9103192|FD-Score:-3.88|P-value:3.47E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.09|P-value:8.93E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.60|P-value:1.30E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.33|P-value:3.70E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.08|P-value:7.71E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:4.24|P-value:8.43E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.14|P-value:6.20E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:3.09|P-value:8.76E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:3.17E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.17|P-value:6.68E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:-3.08|P-value:7.71E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:4.37|P-value:4.50E-6 ID:SGTC_300|Compound:r073-0011|FD-Score:3.11|P-value:8.20E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.06|P-value:9.62E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.76|P-value:6.95E-5 ID:SGTC_681|Compound:1642-0006|FD-Score:3.25|P-value:4.96E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.07|P-value:9.53E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:-3.26|P-value:4.09E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.10|P-value:8.40E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.07|P-value:7.85E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-4.11|P-value:1.21E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.76|P-value:6.83E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:4.49|P-value:2.55E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.39|P-value:2.94E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.23|P-value:8.86E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.11|P-value:8.27E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.49|P-value:2.06E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.15|P-value:1.29E-5 ID:SGTC_1732|Compound:st034308|FD-Score:3.12|P-value:7.82E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.76|P-value:6.74E-7 ID:SGTC_1854|Compound:st056233|FD-Score:5.29|P-value:3.81E-8 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.81|P-value:5.70E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.73|P-value:7.77E-5 ID:SGTC_1882|Compound:5615643|FD-Score:6.74|P-value:3.59E-12 ID:SGTC_1977|Compound:st070720|FD-Score:3.90|P-value:3.79E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.92|P-value:2.80E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.33|P-value:3.72E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.51|P-value:1.56E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-4.86|P-value:3.11E-7 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.07|P-value:9.55E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.39|P-value:2.50E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.02|P-value:9.32E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.14|P-value:8.96E-8 ID:SGTC_2698|Compound:st077697|FD-Score:3.65|P-value:1.07E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.81|P-value:4.61E-5 ID:SGTC_2773|Compound:thioridazine|FD-Score:-6.24|P-value:8.24E-11 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.38|P-value:2.59E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-5.00|P-value:1.44E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.79|P-value:2.03E-9 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.85|P-value:3.85E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-4.01|P-value:1.91E-5 ID:SGTC_2909|Compound:7941780|FD-Score:3.38|P-value:3.09E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.25|P-value:4.99E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.40|P-value:2.85E-4 ID:SGTC_3048|Compound:9093155|FD-Score:3.26|P-value:4.86E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.20|P-value:6.00E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.23|P-value:5.44E-4 ID:SGTC_3171|Compound:9103192|FD-Score:-3.88|P-value:3.47E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.09|P-value:8.93E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.60|P-value:1.30E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.33|P-value:3.70E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.08|P-value:7.71E-4

Top fitness defect scores for YFL007W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1882 5615643 6.74 20.0 µM 3.59E-12 TRP & mitochondrial translation 14 7.87E-12
2 SGTC_2778 tioconazole 5.79 65.1 nM 2.03E-9 ergosterol depletion effects on membrane 32 3.57E-9
3 SGTC_1854 st056233 5.29 32.9 µM 3.81E-8 amide catabolism 6 6.03E-8
4 SGTC_2688 kanamycin b 5.14 96.7 µM 8.96E-8 calcium & mitochondrial duress 232 1.38E-7
5 SGTC_1745 st081495 4.76 74.0 µM 6.74E-7 RNA processing & uracil transport 47 9.68E-7
6 SGTC_1190 1486-1332 4.49 13.0 µM 2.55E-6 8 3.51E-6
7 SGTC_213 1246-0773 4.37 967.0 nM 4.50E-6 15 6.08E-6
8 SGTC_37 0566-0070 4.24 1.6 µM 8.43E-6 21 1.11E-5
9 SGTC_1247 0448-0043 4.23 5.8 µM 8.86E-6 ERG2 30 1.17E-5
10 SGTC_1712 st032288 4.15 53.4 µM 1.29E-5 calcium & mitochondrial duress 178 1.68E-5
11 SGTC_1977 st070720 3.90 65.3 µM 3.79E-5 10 4.77E-5
12 SGTC_1874 staurosporine 3.81 7.6 µM 5.70E-5 cell wall signaling 31 7.08E-5
13 SGTC_1169 aniline yellow 3.76 25.8 µM 6.83E-5 14 8.43E-5
14 SGTC_382 3229-0966 3.76 23.2 µM 6.95E-5 27 8.57E-5
15 SGTC_1876 myriocin 3.73 605.0 nM 7.77E-5 41 9.55E-5
16 SGTC_2698 st077697 3.65 67.5 µM 1.07E-4 21 1.31E-4
17 SGTC_3304 9125678 3.60 46.1 µM 1.30E-4 66 1.57E-4
18 SGTC_1526 st051518 3.49 75.0 µM 2.06E-4 35 2.45E-4
19 SGTC_3014 9081533 3.40 49.5 µM 2.85E-4 17 3.37E-4
20 SGTC_1218 1348-1416 3.39 30.7 µM 2.94E-4 SWF1 & branched chain AA biosynthesis 32 3.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.76E-13 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.122 1.13E-12 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.122 1.48E-12 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.120 3.56E-12 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.117 9.31E-12 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.109 2.52E-10 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.107 4.36E-10 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.105 1.18E-9 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.103 2.05E-9 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.101 4.39E-9 YDR349C YPS7 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum
0.098 1.41E-8 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.094 5.59E-8 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.093 6.33E-8 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.093 6.94E-8 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.089 2.68E-7 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis