Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YFL008W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.124 | 7.58E-13 | YMR244C-A | COA6 | hom | Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress |
0.123 | 8.39E-13 | YOR382W | FIT2 | hom | Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
0.113 | 5.14E-11 | YFL022C | FRS2 | het | Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar |
0.111 | 1.48E-10 | YFR042W | KEG1 | het | Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability |
0.108 | 3.36E-10 | YDL008W | APC11 | het | Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity |
0.106 | 8.08E-10 | YOR119C | RIO1 | het | Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA |
0.102 | 3.15E-9 | YKR032W_d | YKR032W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
0.093 | 6.23E-8 | YGR099W | TEL2 | het | Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 |
0.091 | 1.44E-7 | YML079W_p | YML079W_p | hom | Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm |
0.084 | 1.18E-6 | YDR098C | GRX3 | hom | Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36 |
0.084 | 1.32E-6 | YHR021W-A_p | ECM12_p | hom | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity |
0.083 | 1.47E-6 | YOR155C | ISN1 | hom | Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms |
0.082 | 1.80E-6 | YKL094W | YJU3 | hom | Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family |
0.078 | 5.61E-6 | YDR267C | CIA1 | het | Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein |
0.076 | 1.24E-5 | YNR035C | ARC35 | het | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |