YFL008W / SMC1

Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL008W / SMC1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.62|P-value:2.31E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.09|P-value:3.23E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.01|P-value:5.16E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.43|P-value:7.42E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.63|P-value:1.90E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-5.38|P-value:8.94E-8 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.41|P-value:4.82E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.10|P-value:3.12E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.28|P-value:6.63E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.85|P-value:8.36E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.86|P-value:7.95E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.25|P-value:8.33E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.04|P-value:3.86E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.10|P-value:3.77E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.55|P-value:2.98E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.31|P-value:5.93E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.83|P-value:1.02E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.89|P-value:7.17E-5 ID:SGTC_2484|Compound:5809818|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.00|P-value:4.64E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.57|P-value:2.72E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.31|P-value:6.89E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.07|P-value:3.48E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.72|P-value:1.16E-8 ID:SGTC_2786|Compound:7743617|FD-Score:4.14|P-value:2.55E-5 ID:SGTC_2811|Compound:7967822|FD-Score:-3.98|P-value:5.77E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.90|P-value:8.04E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.25|P-value:8.23E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.55|P-value:2.97E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.34|P-value:5.46E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.83|P-value:1.03E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.16|P-value:9.79E-4 ID:SGTC_3302|Compound:9125395|FD-Score:4.99|P-value:5.53E-7 ID:SGTC_3305|Compound:9127027|FD-Score:-3.35|P-value:5.97E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.62|P-value:2.31E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.09|P-value:3.23E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:-4.01|P-value:5.16E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.43|P-value:7.42E-6 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.63|P-value:1.90E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-5.38|P-value:8.94E-8 ID:SGTC_1105|Compound:epirubicin|FD-Score:-3.41|P-value:4.82E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.10|P-value:3.12E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.28|P-value:6.63E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.85|P-value:8.36E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.86|P-value:7.95E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.25|P-value:8.33E-4 ID:SGTC_1746|Compound:st038117|FD-Score:4.04|P-value:3.86E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-5.10|P-value:3.77E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.55|P-value:2.98E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.31|P-value:5.93E-4 ID:SGTC_2306|Compound:7482397|FD-Score:3.56|P-value:2.45E-4 ID:SGTC_2435|Compound:5706476|FD-Score:-3.83|P-value:1.02E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.89|P-value:7.17E-5 ID:SGTC_2484|Compound:5809818|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.00|P-value:4.64E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.57|P-value:2.72E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.31|P-value:6.89E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.07|P-value:3.48E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.72|P-value:1.16E-8 ID:SGTC_2786|Compound:7743617|FD-Score:4.14|P-value:2.55E-5 ID:SGTC_2811|Compound:7967822|FD-Score:-3.98|P-value:5.77E-5 ID:SGTC_2944|Compound:9067346|FD-Score:-3.90|P-value:8.04E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.25|P-value:8.23E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.55|P-value:2.97E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.34|P-value:5.46E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.83|P-value:1.03E-4 ID:SGTC_3273|Compound:9137859|FD-Score:3.16|P-value:9.79E-4 ID:SGTC_3302|Compound:9125395|FD-Score:4.99|P-value:5.53E-7 ID:SGTC_3305|Compound:9127027|FD-Score:-3.35|P-value:5.97E-4

Top fitness defect scores for YFL008W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2666 tannic acid 5.72 100.0 µM 1.16E-8 iron homeostasis 5 5.29E-9 0.10
2 SGTC_3302 9125395 4.99 16.4 µM 5.53E-7 3 3.05E-7 1.23
3 SGTC_353 1988-1175 4.43 58.3 µM 7.42E-6 unfolded protein response 5 4.66E-6 0.03
4 SGTC_2786 7743617 4.14 45.5 µM 2.55E-5 7 1.70E-5 0.27
5 SGTC_1196 1588-0294 4.10 184.0 µM 3.12E-5 5 2.10E-5 0.37
6 SGTC_268 camptothecin 4.09 39.6 µM 3.23E-5 DNA damage response 41 2.18E-5 0.01
7 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 4.07 70.0 µM 3.48E-5 redox potentiating 9 2.36E-5 0.15
8 SGTC_1746 st038117 4.04 42.0 µM 3.86E-5 5 2.63E-5 0.01
9 SGTC_2568 diosmetin 4.00 100.0 µM 4.64E-5 7 3.19E-5 0.04
10 SGTC_2449 5812982 3.89 45.8 µM 7.17E-5 5 5.03E-5 0.12
11 SGTC_1503 4585-0012 3.86 61.3 µM 7.95E-5 6 5.61E-5 0.11
12 SGTC_1475 4092-1048 3.85 11.7 µM 8.36E-5 plasma membrane duress 5 5.91E-5 0.15
13 SGTC_1529 apigenin 3.78 74.0 µM 1.10E-4 6 7.86E-5 0.30
14 SGTC_49 0717-0965 3.65 32.1 µM 1.78E-4 60S ribosome export 12 1.30E-4 0.18
15 SGTC_392 N-ethylmaleimide 3.63 8.3 µM 1.90E-4 RNA pol III & RNase P/MRP 16 1.39E-4 0.05
16 SGTC_2306 7482397 3.56 179.5 µM 2.45E-4 RPP1 & pyrimidine depletion 13 1.82E-4 0.02
17 SGTC_1187 1391-0724 3.42 117.0 µM 4.15E-4 amide catabolism 7 3.17E-4 0.04
18 SGTC_3057 9095946 3.34 49.5 µM 5.46E-4 Golgi 7 4.23E-4 0.08
19 SGTC_2116 5511452 3.31 16.9 µM 5.93E-4 6 4.61E-4 0.03
20 SGTC_1404 3909-7820 3.28 48.3 µM 6.63E-4 60S ribosome export 8 5.18E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 7.58E-13 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.123 8.39E-13 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.113 5.14E-11 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.111 1.48E-10 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.108 3.36E-10 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.106 8.08E-10 YOR119C RIO1 het Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
0.102 3.15E-9 YKR032W_d YKR032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 6.23E-8 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.091 1.44E-7 YML079W_p YML079W_p hom Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
0.084 1.18E-6 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.084 1.32E-6 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.083 1.47E-6 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.082 1.80E-6 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.078 5.61E-6 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.076 1.24E-5 YNR035C ARC35 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin