HIPHOP chemogenomics database

YFL010C / WWM1

WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1

Zygosity: Homozygous strain

fixedexpanded
Profile for YFL010C / WWM1

Click on Significant Values for Screen Details

Top fitness defect scores for YFL010C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1400	3771-8998	5.68	51.5 µM	5.49E-9		1	6.74E-9
2	SGTC_1254	0550-0035	4.87	264.0 µM	4.77E-7		6	5.62E-7
3	SGTC_2847	9005661	4.86	71.4 µM	4.94E-7		6	5.81E-7
4	SGTC_184	1494-0393	4.68	24.7 µM	1.23E-6		44	1.44E-6
5	SGTC_1383	3049-0032	4.55	20.7 µM	2.33E-6	60S ribosome export	13	2.70E-6
6	SGTC_862	0452-0056	4.48	10.2 µM	3.18E-6	azole & statin	25	3.67E-6
7	SGTC_181	1447-1644	4.12	8.1 µM	1.68E-5	endomembrane recycling	30	1.90E-5
8	SGTC_2970	9090938	4.01	41.9 µM	2.73E-5	RNA processing & uracil transport	38	3.09E-5
9	SGTC_1914	st062367	4.00	72.6 µM	2.85E-5		19	3.22E-5
10	SGTC_2054	5233173	3.82	129.0 µM	5.87E-5	mitochondrial response to ROS	60	6.59E-5
11	SGTC_761	k216-0224	3.71	480.0 µM	9.32E-5		25	1.04E-4
12	SGTC_163	1327-0036	3.62	7.5 µM	1.30E-4		130	1.45E-4
13	SGTC_376	3970-0862	3.61	59.1 µM	1.40E-4		28	1.55E-4
14	SGTC_2064	5220758	3.56	200.0 µM	1.69E-4		49	1.87E-4
15	SGTC_2351	9026858	3.56	72.3 µM	1.70E-4	RNA processing & uracil transport	37	1.89E-4
16	SGTC_1918	oxolan-2-ylmethyl 3-bromobenzoate	3.42	70.1 µM	2.79E-4		54	3.08E-4
17	SGTC_1315	1237-0019	3.41	3.7 µM	2.96E-4		17	3.26E-4
18	SGTC_2129	girgensonine	3.37	121.0 µM	3.44E-4	heme biosynthesis & mitochondrial translocase	59	3.79E-4
19	SGTC_178	4092-0806	3.37	87.5 µM	3.46E-4	ergosterol depletion effects on membrane	126	3.81E-4
20	SGTC_2130	NSC 7	3.28	2.5 µM	4.66E-4	copper-dependent oxidative stress	66	5.12E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.108	4.59E-10	YNL118C	DCP2	het	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
0.104	2.04E-9	YJR035W	RAD26	hom	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.103	2.14E-9	YER089C	PTC2	hom	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.102	3.77E-9	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.101	5.25E-9	YLL057C	JLP1	hom	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
0.099	8.58E-9	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.086	6.53E-7	YPL144W	POC4	hom	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.084	1.17E-6	YIR012W	SQT1	het	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.083	1.72E-6	YNL075W	IMP4	het	Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.081	2.81E-6	YFL007W	BLM10	hom	Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
0.081	2.82E-6	YBR258C	SHG1	hom	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.078	6.52E-6	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.078	6.52E-6	YBR186W	PCH2	hom	Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.078	6.68E-6	YLR189C	ATG26	hom	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.078	7.10E-6	YOR093C_p	YOR093C_p	hom	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents