YFL010W-A / AUA1

Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL010W-A / AUA1

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.87|P-value:8.54E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.26|P-value:7.48E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.25|P-value:8.90E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.25|P-value:2.12E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.44|P-value:4.67E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.35|P-value:5.55E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.76|P-value:1.28E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.61|P-value:2.56E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.72|P-value:2.70E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.91|P-value:8.23E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.32|P-value:6.90E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.93|P-value:7.73E-5 ID:SGTC_1590|Compound:st077108|FD-Score:4.09|P-value:4.01E-5 ID:SGTC_1773|Compound:st048542|FD-Score:3.72|P-value:1.71E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.44|P-value:4.63E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.59|P-value:2.76E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.76|P-value:2.28E-6 ID:SGTC_1930|Compound:st074634|FD-Score:4.21|P-value:2.55E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.89|P-value:7.69E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.71|P-value:1.79E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.23|P-value:9.54E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.33|P-value:1.52E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.45|P-value:4.56E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-3.24|P-value:8.18E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.67|P-value:2.02E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.23|P-value:9.49E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-3.96|P-value:5.95E-5 ID:SGTC_2195|Compound:6536160|FD-Score:3.70|P-value:1.82E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.27|P-value:7.39E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-7.23|P-value:1.19E-12 ID:SGTC_2313|Compound:7726885|FD-Score:-5.46|P-value:5.75E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.88|P-value:9.50E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.88|P-value:9.39E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.80|P-value:1.27E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.11|P-value:3.24E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-4.07|P-value:3.89E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.62|P-value:2.49E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.37|P-value:5.99E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.94|P-value:8.11E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.71|P-value:1.55E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.58|P-value:3.72E-8 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.87|P-value:8.44E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.32|P-value:6.17E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.99|P-value:6.05E-5 ID:SGTC_2934|Compound:9036370|FD-Score:6.21|P-value:1.03E-9 ID:SGTC_2966|Compound:9084041|FD-Score:3.28|P-value:8.06E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.51|P-value:7.08E-6 ID:SGTC_3254|Compound:9136651|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-4.10|P-value:3.33E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.54|P-value:6.19E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.87|P-value:8.54E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.26|P-value:7.48E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.25|P-value:8.90E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.25|P-value:2.12E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.44|P-value:4.67E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.35|P-value:5.55E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:-3.76|P-value:1.28E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.61|P-value:2.56E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.72|P-value:2.70E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.91|P-value:8.23E-5 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.32|P-value:6.90E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.93|P-value:7.73E-5 ID:SGTC_1590|Compound:st077108|FD-Score:4.09|P-value:4.01E-5 ID:SGTC_1773|Compound:st048542|FD-Score:3.72|P-value:1.71E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.44|P-value:4.63E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.59|P-value:2.76E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.76|P-value:2.28E-6 ID:SGTC_1930|Compound:st074634|FD-Score:4.21|P-value:2.55E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.89|P-value:7.69E-5 ID:SGTC_2004|Compound:4023728|FD-Score:3.71|P-value:1.79E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.23|P-value:9.54E-4 ID:SGTC_2070|Compound:5230947|FD-Score:4.33|P-value:1.52E-5 ID:SGTC_2082|Compound:5219693|FD-Score:3.45|P-value:4.56E-4 ID:SGTC_2141|Compound:5621638|FD-Score:-3.24|P-value:8.18E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.67|P-value:2.02E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.23|P-value:9.49E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-3.96|P-value:5.95E-5 ID:SGTC_2195|Compound:6536160|FD-Score:3.70|P-value:1.82E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.27|P-value:7.39E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-7.23|P-value:1.19E-12 ID:SGTC_2313|Compound:7726885|FD-Score:-5.46|P-value:5.75E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.88|P-value:9.50E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.88|P-value:9.39E-5 ID:SGTC_2424|Compound:5537928|FD-Score:3.80|P-value:1.27E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-4.11|P-value:3.24E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-4.07|P-value:3.89E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.62|P-value:2.49E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.37|P-value:5.99E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-4.94|P-value:8.11E-7 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.71|P-value:1.55E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.58|P-value:3.72E-8 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.87|P-value:8.44E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.32|P-value:6.17E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.99|P-value:6.05E-5 ID:SGTC_2934|Compound:9036370|FD-Score:6.21|P-value:1.03E-9 ID:SGTC_2966|Compound:9084041|FD-Score:3.28|P-value:8.06E-4 ID:SGTC_3213|Compound:9129884|FD-Score:4.51|P-value:7.08E-6 ID:SGTC_3254|Compound:9136651|FD-Score:3.38|P-value:5.73E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-4.10|P-value:3.33E-5 ID:SGTC_3306|Compound:9127676|FD-Score:4.54|P-value:6.19E-6

Top fitness defect scores for YFL010W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2934 9036370 6.21 36.9 µM 1.03E-9 9 2.62E-10
2 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 5.58 100.0 µM 3.72E-8 60S ribosome export 3 1.21E-8
3 SGTC_1869 3',7'-dimethoxyflavone 4.76 40.3 µM 2.28E-6 10 9.84E-7
4 SGTC_1097 itavastatin 4.72 7.2 µM 2.70E-6 azole & statin 11 1.18E-6
5 SGTC_3306 9127676 4.54 59.8 µM 6.19E-6 12 2.87E-6
6 SGTC_3213 9129884 4.51 49.5 µM 7.08E-6 14 3.31E-6
7 SGTC_2070 5230947 4.33 200.0 µM 1.52E-5 3 7.51E-6
8 SGTC_669 0108-0021 4.25 26.2 µM 2.12E-5 fatty acid desaturase (OLE1) 66 1.07E-5
9 SGTC_1930 st074634 4.21 34.3 µM 2.55E-5 RNA pol III & RNase P/MRP 31 1.30E-5
10 SGTC_1590 st077108 4.09 57.8 µM 4.01E-5 6 2.12E-5
11 SGTC_2815 7968870 3.99 71.4 µM 6.05E-5 21 3.28E-5
12 SGTC_1509 1326-1131 3.93 80.0 µM 7.73E-5 13 4.27E-5
13 SGTC_1146 3579-1023 3.91 7.0 µM 8.23E-5 16 4.56E-5
14 SGTC_2423 st077119 3.88 87.2 µM 9.39E-5 11 5.26E-5
15 SGTC_2412 st077135 3.88 33.4 µM 9.50E-5 27 5.32E-5
16 SGTC_2573 2',4'-dihydroxychalcone 3.81 15.0 µM 1.20E-4 57 6.82E-5
17 SGTC_2424 5537928 3.80 59.2 µM 1.27E-4 42 7.23E-5
18 SGTC_1773 st048542 3.72 73.6 µM 1.71E-4 53 9.98E-5
19 SGTC_2004 4023728 3.71 41.9 µM 1.79E-4 32 1.05E-4
20 SGTC_2195 6536160 3.70 144.2 µM 1.82E-4 60S ribosome export 16 1.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.28E-13 YMR297W PRC1 hom Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
0.100 5.78E-9 YIL084C SDS3 hom Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
0.089 2.26E-7 YOL028C YAP7 hom Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.081 2.53E-6 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.079 5.28E-6 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.077 7.68E-6 YKL127W PGM1 hom Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
0.077 7.76E-6 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress
0.076 1.14E-5 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.076 1.15E-5 YKR049C FMP46 hom Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.21E-5 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.071 3.87E-5 YLR209C PNP1 hom Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
0.071 3.89E-5 YBL096C_d YBL096C_d hom Non-essential protein of unknown function
0.071 4.36E-5 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.070 5.22E-5 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.069 6.70E-5 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication