YFL011W / HXT10

Putative hexose transporter, expressed at low levels and expression is repressed by glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL011W / HXT10

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:3.76|P-value:1.74E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.91|P-value:6.24E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:5.24|P-value:2.72E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:4.52|P-value:7.85E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:3.86|P-value:1.16E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.90|P-value:1.00E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.31|P-value:8.33E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.46|P-value:5.05E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.33|P-value:5.30E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.14|P-value:3.86E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.96|P-value:5.05E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.38|P-value:6.64E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.90|P-value:1.40E-6 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.57|P-value:3.40E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.53|P-value:3.88E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:4.41|P-value:1.27E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.81|P-value:9.20E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.28|P-value:9.02E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.92|P-value:9.26E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.61|P-value:2.95E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.35|P-value:7.15E-4 ID:SGTC_2088|Compound:5278280|FD-Score:6.07|P-value:2.97E-9 ID:SGTC_2103|Compound:5378138|FD-Score:4.13|P-value:4.09E-5 ID:SGTC_2282|Compound:7944268|FD-Score:6.12|P-value:2.22E-9 ID:SGTC_2286|Compound:7945697|FD-Score:-4.85|P-value:1.04E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.68|P-value:2.33E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.66|P-value:2.48E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.13|P-value:4.13E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.44|P-value:5.29E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.47|P-value:4.76E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.70|P-value:2.09E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.44|P-value:6.70E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.71|P-value:3.37E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.78|P-value:1.52E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.84|P-value:8.28E-5 ID:SGTC_2830|Compound:7992007|FD-Score:3.98|P-value:7.51E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.98|P-value:4.67E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.84|P-value:1.85E-6 ID:SGTC_3053|Compound:9095903|FD-Score:3.64|P-value:2.70E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.32|P-value:8.12E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.76|P-value:1.74E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.91|P-value:6.24E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:5.24|P-value:2.72E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:4.52|P-value:7.85E-6 ID:SGTC_345|Compound:1362-0200|FD-Score:3.86|P-value:1.16E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.90|P-value:1.00E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.31|P-value:8.33E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.46|P-value:5.05E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.33|P-value:5.30E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.14|P-value:3.86E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.96|P-value:5.05E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.38|P-value:6.64E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.90|P-value:1.40E-6 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.57|P-value:3.40E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.53|P-value:3.88E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:4.41|P-value:1.27E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-3.81|P-value:9.20E-5 ID:SGTC_1861|Compound:st057647|FD-Score:3.28|P-value:9.02E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.92|P-value:9.26E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.61|P-value:2.95E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.35|P-value:7.15E-4 ID:SGTC_2088|Compound:5278280|FD-Score:6.07|P-value:2.97E-9 ID:SGTC_2103|Compound:5378138|FD-Score:4.13|P-value:4.09E-5 ID:SGTC_2282|Compound:7944268|FD-Score:6.12|P-value:2.22E-9 ID:SGTC_2286|Compound:7945697|FD-Score:-4.85|P-value:1.04E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.68|P-value:2.33E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.66|P-value:2.48E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.13|P-value:4.13E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.44|P-value:5.29E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.47|P-value:4.76E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.70|P-value:2.09E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.44|P-value:6.70E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.71|P-value:3.37E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:5.78|P-value:1.52E-8 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.84|P-value:8.28E-5 ID:SGTC_2830|Compound:7992007|FD-Score:3.98|P-value:7.51E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.98|P-value:4.67E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.71|P-value:2.08E-4 ID:SGTC_2973|Compound:9094665|FD-Score:4.84|P-value:1.85E-6 ID:SGTC_3053|Compound:9095903|FD-Score:3.64|P-value:2.70E-4 ID:SGTC_3094|Compound:9117742|FD-Score:3.32|P-value:8.12E-4

Top fitness defect scores for YFL011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2282 7944268 6.12 200.0 µM 2.22E-9 RPP1 & pyrimidine depletion 5 4.60E-10
2 SGTC_2088 5278280 6.07 127.4 µM 2.97E-9 4 6.29E-10
3 SGTC_2594 a-mangostin 5.78 100.0 µM 1.52E-8 11 3.66E-9
4 SGTC_286 k060-0067 5.24 22.9 µM 2.72E-7 tubulin folding & SWR complex 10 8.16E-8
5 SGTC_1140 3229-1848 4.90 3.0 µM 1.40E-6 5 4.79E-7
6 SGTC_2973 9094665 4.84 18.0 µM 1.85E-6 NEO1 15 6.45E-7
7 SGTC_2592 piperlongumine 4.71 83.3 µM 3.37E-6 TSC3-RPN4 15 1.23E-6
8 SGTC_301 4119-0100 4.52 24.5 µM 7.85E-6 NEO1 68 3.06E-6
9 SGTC_1400 3771-8998 4.41 51.5 µM 1.27E-5 5 5.16E-6
10 SGTC_1120 ficusin 4.14 1.8 µM 3.86E-5 19 1.71E-5
11 SGTC_2103 5378138 4.13 10.0 µM 4.09E-5 12 1.81E-5
12 SGTC_2405 ticlatone 4.13 3.5 µM 4.13E-5 63 1.84E-5
13 SGTC_2830 7992007 3.98 71.4 µM 7.51E-5 22 3.50E-5
14 SGTC_1995 st072814 3.92 61.1 µM 9.26E-5 15 4.39E-5
15 SGTC_348 k064-0012 3.90 10.7 µM 1.00E-4 60S ribosome export 15 4.78E-5
16 SGTC_2603 homopterocarpin 3.88 100.0 µM 1.07E-4 42 5.13E-5
17 SGTC_345 1362-0200 3.86 395.0 µM 1.16E-4 21 5.57E-5
18 SGTC_146 3448-8650 3.76 53.1 µM 1.74E-4 NEO1-PIK1 152 8.67E-5
19 SGTC_2970 9090938 3.71 41.9 µM 2.08E-4 RNA processing & uracil transport 50 1.05E-4
20 SGTC_2448 5185112 3.70 27.2 µM 2.09E-4 16 1.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.52E-14 YLR104W_p LCL2_p hom Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.125 3.31E-13 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.096 2.48E-8 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.089 2.14E-7 YJL074C SMC3 het Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
0.089 2.57E-7 YOR355W GDS1 hom Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.58E-7 YKR062W TFA2 het TFIIE small subunit, involved in RNA polymerase II transcription initiation
0.087 4.60E-7 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.085 9.17E-7 YDR246W-A_p YDR246W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.084 1.22E-6 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.082 1.96E-6 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.081 2.50E-6 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.081 2.55E-6 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.079 4.09E-6 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.079 4.67E-6 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.077 8.30E-6 YLR012C_p YLR012C_p hom Putative protein of unknown function; YLR012C is not an essential gene