YFL012W_p

Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL012W / YFL012W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.61|P-value:4.64E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.96|P-value:1.39E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.70|P-value:3.36E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:-7.04|P-value:3.72E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:5.32|P-value:5.02E-7 ID:SGTC_228|Compound:caffeine|FD-Score:3.79|P-value:2.50E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-7.72|P-value:4.89E-13 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.67|P-value:3.42E-4 ID:SGTC_469|Compound:w7|FD-Score:3.50|P-value:6.57E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.25|P-value:4.10E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.77|P-value:2.65E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.79|P-value:2.46E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.28|P-value:3.75E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.94|P-value:2.35E-8 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.44|P-value:8.03E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.76|P-value:2.74E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.02|P-value:1.13E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.95|P-value:1.44E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.57|P-value:5.20E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.55|P-value:5.61E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.83|P-value:4.43E-6 ID:SGTC_1954|Compound:st077032|FD-Score:3.98|P-value:1.29E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_2034|Compound:5197015|FD-Score:4.33|P-value:3.52E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.99|P-value:1.23E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.44|P-value:7.96E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.75|P-value:2.57E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.80|P-value:2.40E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.79|P-value:2.47E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.46|P-value:7.43E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.74|P-value:6.39E-8 ID:SGTC_2811|Compound:7967822|FD-Score:3.79|P-value:2.50E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.29|P-value:3.99E-5 ID:SGTC_2931|Compound:9014674|FD-Score:3.40|P-value:9.03E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-4.10|P-value:7.34E-5 ID:SGTC_3083|Compound:9117465|FD-Score:4.03|P-value:1.06E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.34|P-value:9.73E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.92|P-value:1.60E-4 ID:SGTC_3306|Compound:9127676|FD-Score:6.21|P-value:5.48E-9 ID:SGTC_3308|Compound:9128332|FD-Score:4.71|P-value:7.59E-6 ID:SGTC_3339|Compound:9145883|FD-Score:-3.35|P-value:9.41E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.56|P-value:4.89E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.61|P-value:4.64E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.96|P-value:1.39E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.70|P-value:3.36E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:-7.04|P-value:3.72E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:5.32|P-value:5.02E-7 ID:SGTC_228|Compound:caffeine|FD-Score:3.79|P-value:2.50E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-7.72|P-value:4.89E-13 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.67|P-value:3.42E-4 ID:SGTC_469|Compound:w7|FD-Score:3.50|P-value:6.57E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-4.25|P-value:4.10E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.77|P-value:2.65E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.79|P-value:2.46E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-4.28|P-value:3.75E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.94|P-value:2.35E-8 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.44|P-value:8.03E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.76|P-value:2.74E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.02|P-value:1.13E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.95|P-value:1.44E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.57|P-value:5.20E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.55|P-value:5.61E-4 ID:SGTC_1939|Compound:st074455|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.83|P-value:4.43E-6 ID:SGTC_1954|Compound:st077032|FD-Score:3.98|P-value:1.29E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.97|P-value:1.30E-4 ID:SGTC_2034|Compound:5197015|FD-Score:4.33|P-value:3.52E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.99|P-value:1.23E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.44|P-value:7.96E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.75|P-value:2.57E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.80|P-value:2.40E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.79|P-value:2.47E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.46|P-value:7.43E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.74|P-value:6.39E-8 ID:SGTC_2811|Compound:7967822|FD-Score:3.79|P-value:2.50E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.29|P-value:3.99E-5 ID:SGTC_2931|Compound:9014674|FD-Score:3.40|P-value:9.03E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-4.10|P-value:7.34E-5 ID:SGTC_3083|Compound:9117465|FD-Score:4.03|P-value:1.06E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.34|P-value:9.73E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.92|P-value:1.60E-4 ID:SGTC_3306|Compound:9127676|FD-Score:6.21|P-value:5.48E-9 ID:SGTC_3308|Compound:9128332|FD-Score:4.71|P-value:7.59E-6 ID:SGTC_3339|Compound:9145883|FD-Score:-3.35|P-value:9.41E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.56|P-value:4.89E-4

Top fitness defect scores for YFL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3306 9127676 6.21 59.8 µM 5.48E-9 3 2.61E-10
2 SGTC_1580 hydrocortisone 21-hemisuccinate 5.94 43.2 µM 2.35E-8 3 1.44E-9
3 SGTC_2758 dehydroepiandrosterone 5.74 69.3 µM 6.39E-8 20 4.67E-9
4 SGTC_163 1327-0036 5.32 7.5 µM 5.02E-7 59 5.23E-8
5 SGTC_1944 st076371 4.83 56.9 µM 4.43E-6 11 6.71E-7
6 SGTC_3308 9128332 4.71 17.6 µM 7.59E-6 plasma membrane duress 53 1.26E-6
7 SGTC_2034 5197015 4.33 53.1 µM 3.52E-5 SWF1 & branched chain AA biosynthesis 16 7.61E-6
8 SGTC_2916 7875993 4.29 68.8 µM 3.99E-5 18 8.80E-6
9 SGTC_3083 9117465 4.03 49.5 µM 1.06E-4 21 2.78E-5
10 SGTC_1675 st018485 4.02 24.5 µM 1.13E-4 60S ribosome export 26 2.97E-5
11 SGTC_2042 p-Dimethylaminoacetophenone 3.99 200.0 µM 1.23E-4 16 3.29E-5
12 SGTC_1954 st077032 3.98 68.9 µM 1.29E-4 21 3.47E-5
13 SGTC_1983 st071813 3.97 46.9 µM 1.30E-4 RPP1 & pyrimidine depletion 19 3.52E-5
14 SGTC_40 0327-0103 3.97 19.8 µM 1.30E-4 32 3.52E-5
15 SGTC_45 0kpi-0036 3.96 14.9 µM 1.39E-4 excess fatty acid 25 3.81E-5
16 SGTC_1910 st062352 3.95 60.4 µM 1.44E-4 38 3.95E-5
17 SGTC_533 1222-0222 3.94 6.7 µM 1.49E-4 PDR1 29 4.10E-5
18 SGTC_1939 st074455 3.94 53.6 µM 1.49E-4 28 4.12E-5
19 SGTC_3303 9125618 3.92 40.6 µM 1.60E-4 49 4.49E-5
20 SGTC_2629 bisabolol 3.80 100.0 µM 2.40E-4 25 7.19E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.58E-8 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.097 1.83E-8 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.095 3.90E-8 YJL194W CDC6 het Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.091 1.26E-7 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.088 3.37E-7 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.087 5.08E-7 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.085 7.34E-7 YPR053C_d YPR053C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
0.083 1.58E-6 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.081 2.41E-6 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.081 2.86E-6 YDR333C RQC1 hom Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.076 1.00E-5 YLR174W IDP2 hom Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication
0.075 1.31E-5 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.075 1.52E-5 YDR341C YDR341C het Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.074 1.59E-5 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.074 1.85E-5 YGL117W_p YGL117W_p hom Putative protein of unknown function