HIPHOP chemogenomics database

YFL013C / IES1

Subunit of the INO80 chromatin remodeling complex

Zygosity: Homozygous strain

fixedexpanded
Profile for YFL013C / IES1

Click on Significant Values for Screen Details

Top fitness defect scores for YFL013C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_682	0kpi-0099	8.20	17.0 µM	9.23E-15		13	1.19E-16
2	SGTC_2858	9025781	7.92	9.0 µM	7.09E-14	sphingolipid biosynthesis & PDR1	28	1.20E-15
3	SGTC_36	0335-0881	7.31	14.2 µM	4.40E-12	ubiquinone biosynthesis & proteasome	45	1.30E-13
4	SGTC_163	1327-0036	6.91	7.5 µM	5.97E-11		33	2.50E-12
5	SGTC_59	0330-0160	6.60	1.3 µM	3.73E-10		27	2.00E-11
6	SGTC_1399	3562-5772	6.53	25.0 µM	5.85E-10	RPP1 & pyrimidine depletion	2	3.33E-11
7	SGTC_213	1246-0773	6.17	967.0 nM	4.45E-9		4	3.33E-10
8	SGTC_514	4466-0038	5.94	2.6 nM	1.56E-8	cell wall	74	1.38E-9
9	SGTC_158	k038-0087	5.80	26.4 µM	3.36E-8	ubiquinone biosynthesis & proteasome	72	3.31E-9
10	SGTC_513	4245-1575	5.79	41.7 µM	3.50E-8	unfolded protein response	54	3.47E-9
11	SGTC_2917	7979103	5.51	53.8 µM	1.52E-7		6	1.84E-8
12	SGTC_1889	st059080	5.26	5.2 µM	5.17E-7		3	7.39E-8
13	SGTC_15	0266-0086	5.18	27.1 µM	7.23E-7	endomembrane recycling	31	1.08E-7
14	SGTC_2651	1327-0036	4.93	5.0 µM	2.37E-6		110	4.17E-7
15	SGTC_1959	st077091	4.87	55.8 µM	3.02E-6	RPP1 & pyrimidine depletion	26	5.48E-7
16	SGTC_2626	ethyl orsellinate	4.63	100.0 µM	8.77E-6		19	1.85E-6
17	SGTC_142	0335-0849	4.57	62.7 µM	1.10E-5	ubiquinone biosynthesis & proteasome	101	2.40E-6
18	SGTC_2541	muurolladie-3-one	4.42	83.1 µM	2.10E-5	excess fatty acid	17	4.97E-6
19	SGTC_137	0438-0332	4.39	85.4 µM	2.36E-5	ubiquinone biosynthesis & proteasome	101	5.70E-6
20	SGTC_1330	1469-0054	4.29	61.8 µM	3.53E-5	iron homeostasis	12	8.98E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.372	6.83E-110	YFL013W-A_d	YFL013W-A_d	hom	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.271	1.80E-57	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.246	1.82E-47	YPR065W	ROX1	hom	Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.223	6.47E-39	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213	1.17E-35	YDL002C	NHP10	hom	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.212	2.68E-35	YER019C-A	SBH2	hom	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.212	2.68E-35	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.202	4.08E-32	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.200	1.47E-31	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.196	3.10E-30	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.194	7.88E-30	YIL090W	ICE2	hom	Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.193	1.82E-29	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.189	2.52E-28	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.189	2.94E-28	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.188	6.47E-28	YNL111C	CYB5	hom	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation