Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.372 |
6.83E-110 |
YFL013W-A_d |
YFL013W-A_d |
hom |
Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching |
0.271 |
1.80E-57 |
YPR064W_d |
YPR064W_d |
hom |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.246 |
1.82E-47 |
YPR065W |
ROX1 |
hom |
Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance |
0.223 |
6.47E-39 |
YML034C-A_d |
YML034C-A_d |
hom |
Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.213 |
1.17E-35 |
YDL002C |
NHP10 |
hom |
Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair |
0.212 |
2.68E-35 |
YER019C-A |
SBH2 |
hom |
Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p |
0.212 |
2.68E-35 |
YLR201C |
COQ9 |
hom |
Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes |
0.202 |
4.08E-32 |
YOR254C |
SEC63 |
het |
Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
0.200 |
1.47E-31 |
YDR204W |
COQ4 |
hom |
Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex |
0.196 |
3.10E-30 |
YNR042W_d |
YNR042W_d |
hom |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 |
0.194 |
7.88E-30 |
YIL090W |
ICE2 |
hom |
Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells |
0.193 |
1.82E-29 |
YGR255C |
COQ6 |
hom |
Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) |
0.189 |
2.52E-28 |
YDL183C |
YDL183C |
hom |
Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene |
0.189 |
2.94E-28 |
YPR024W |
YME1 |
hom |
Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover |
0.188 |
6.47E-28 |
YNL111C |
CYB5 |
hom |
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation |