YFL013C / IES1

Subunit of the INO80 chromatin remodeling complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL013C / IES1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.40|P-value:8.58E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.50|P-value:3.90E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:5.18|P-value:7.23E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:7.31|P-value:4.40E-12 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.57|P-value:6.06E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.33|P-value:7.97E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:6.60|P-value:3.73E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:4.39|P-value:2.36E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.57|P-value:1.10E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:5.80|P-value:3.36E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:6.91|P-value:5.97E-11 ID:SGTC_200|Compound:k038-0079|FD-Score:3.86|P-value:1.76E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:6.17|P-value:4.45E-9 ID:SGTC_259|Compound:usnic acid|FD-Score:3.87|P-value:1.70E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.85|P-value:1.88E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.33|P-value:6.69E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.69|P-value:3.22E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.45|P-value:7.23E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.79|P-value:3.50E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:5.94|P-value:1.56E-8 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.29|P-value:1.97E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.90|P-value:9.31E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.20|P-value:9.23E-15 ID:SGTC_696|Compound:1560-0013|FD-Score:3.54|P-value:5.34E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.79|P-value:2.27E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.37|P-value:5.89E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.22|P-value:9.75E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.29|P-value:3.53E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:6.53|P-value:5.85E-10 ID:SGTC_1712|Compound:st032288|FD-Score:-3.50|P-value:3.84E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.26|P-value:5.17E-7 ID:SGTC_1959|Compound:st077091|FD-Score:4.87|P-value:3.02E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.35|P-value:6.30E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-5.48|P-value:8.63E-8 ID:SGTC_2375|Compound:9072683|FD-Score:-3.95|P-value:7.68E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.57|P-value:3.03E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-4.01|P-value:6.14E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.46|P-value:6.96E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.42|P-value:2.10E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.96|P-value:7.39E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.29|P-value:7.60E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.63|P-value:8.77E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.93|P-value:2.37E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.44|P-value:4.64E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.55|P-value:5.14E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.92|P-value:7.09E-14 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:6.50E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.51|P-value:1.52E-7 ID:SGTC_2930|Compound:9013230|FD-Score:-3.60|P-value:2.75E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.15|P-value:6.11E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.35|P-value:9.89E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.70|P-value:3.16E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.65|P-value:3.77E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:1.11E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.59|P-value:4.52E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-5.10|P-value:5.63E-7 ID:SGTC_3335|Compound:9143315|FD-Score:3.45|P-value:7.28E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.40|P-value:8.58E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.50|P-value:3.90E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:5.18|P-value:7.23E-7 ID:SGTC_36|Compound:0335-0881|FD-Score:7.31|P-value:4.40E-12 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.57|P-value:6.06E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.33|P-value:7.97E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:6.60|P-value:3.73E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:4.39|P-value:2.36E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.57|P-value:1.10E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:5.80|P-value:3.36E-8 ID:SGTC_163|Compound:1327-0036|FD-Score:6.91|P-value:5.97E-11 ID:SGTC_200|Compound:k038-0079|FD-Score:3.86|P-value:1.76E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:6.17|P-value:4.45E-9 ID:SGTC_259|Compound:usnic acid|FD-Score:3.87|P-value:1.70E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.85|P-value:1.88E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.33|P-value:6.69E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.69|P-value:3.22E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.45|P-value:7.23E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.79|P-value:3.50E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:5.94|P-value:1.56E-8 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.29|P-value:1.97E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.90|P-value:9.31E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:8.20|P-value:9.23E-15 ID:SGTC_696|Compound:1560-0013|FD-Score:3.54|P-value:5.34E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:3.79|P-value:2.27E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.37|P-value:5.89E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.22|P-value:9.75E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:4.29|P-value:3.53E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:6.53|P-value:5.85E-10 ID:SGTC_1712|Compound:st032288|FD-Score:-3.50|P-value:3.84E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.26|P-value:5.17E-7 ID:SGTC_1959|Compound:st077091|FD-Score:4.87|P-value:3.02E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-3.35|P-value:6.30E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-5.48|P-value:8.63E-8 ID:SGTC_2375|Compound:9072683|FD-Score:-3.95|P-value:7.68E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.57|P-value:3.03E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-4.01|P-value:6.14E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.46|P-value:6.96E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.42|P-value:2.10E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.96|P-value:7.39E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.29|P-value:7.60E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.63|P-value:8.77E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.93|P-value:2.37E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.44|P-value:4.64E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.55|P-value:5.14E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.92|P-value:7.09E-14 ID:SGTC_2896|Compound:9052656|FD-Score:-3.34|P-value:6.50E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.51|P-value:1.52E-7 ID:SGTC_2930|Compound:9013230|FD-Score:-3.60|P-value:2.75E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.15|P-value:6.11E-5 ID:SGTC_3178|Compound:9107506|FD-Score:3.35|P-value:9.89E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.70|P-value:3.16E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.65|P-value:3.77E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.99|P-value:1.11E-4 ID:SGTC_3317|Compound:9138495|FD-Score:3.59|P-value:4.52E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-5.10|P-value:5.63E-7 ID:SGTC_3335|Compound:9143315|FD-Score:3.45|P-value:7.28E-4

Top fitness defect scores for YFL013C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_682 0kpi-0099 8.20 17.0 µM 9.23E-15 13 1.19E-16
2 SGTC_2858 9025781 7.92 9.0 µM 7.09E-14 sphingolipid biosynthesis & PDR1 28 1.20E-15
3 SGTC_36 0335-0881 7.31 14.2 µM 4.40E-12 ubiquinone biosynthesis & proteasome 45 1.30E-13
4 SGTC_163 1327-0036 6.91 7.5 µM 5.97E-11 33 2.50E-12
5 SGTC_59 0330-0160 6.60 1.3 µM 3.73E-10 27 2.00E-11
6 SGTC_1399 3562-5772 6.53 25.0 µM 5.85E-10 RPP1 & pyrimidine depletion 2 3.33E-11
7 SGTC_213 1246-0773 6.17 967.0 nM 4.45E-9 4 3.33E-10
8 SGTC_514 4466-0038 5.94 2.6 nM 1.56E-8 cell wall 74 1.38E-9
9 SGTC_158 k038-0087 5.80 26.4 µM 3.36E-8 ubiquinone biosynthesis & proteasome 72 3.31E-9
10 SGTC_513 4245-1575 5.79 41.7 µM 3.50E-8 unfolded protein response 54 3.47E-9
11 SGTC_2917 7979103 5.51 53.8 µM 1.52E-7 6 1.84E-8
12 SGTC_1889 st059080 5.26 5.2 µM 5.17E-7 3 7.39E-8
13 SGTC_15 0266-0086 5.18 27.1 µM 7.23E-7 endomembrane recycling 31 1.08E-7
14 SGTC_2651 1327-0036 4.93 5.0 µM 2.37E-6 110 4.17E-7
15 SGTC_1959 st077091 4.87 55.8 µM 3.02E-6 RPP1 & pyrimidine depletion 26 5.48E-7
16 SGTC_2626 ethyl orsellinate 4.63 100.0 µM 8.77E-6 19 1.85E-6
17 SGTC_142 0335-0849 4.57 62.7 µM 1.10E-5 ubiquinone biosynthesis & proteasome 101 2.40E-6
18 SGTC_2541 muurolladie-3-one 4.42 83.1 µM 2.10E-5 excess fatty acid 17 4.97E-6
19 SGTC_137 0438-0332 4.39 85.4 µM 2.36E-5 ubiquinone biosynthesis & proteasome 101 5.70E-6
20 SGTC_1330 1469-0054 4.29 61.8 µM 3.53E-5 iron homeostasis 12 8.98E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 6.83E-110 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.271 1.80E-57 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.246 1.82E-47 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.223 6.47E-39 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213 1.17E-35 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.212 2.68E-35 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.212 2.68E-35 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.202 4.08E-32 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.200 1.47E-31 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.196 3.10E-30 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.194 7.88E-30 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.193 1.82E-29 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.189 2.52E-28 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.189 2.94E-28 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.188 6.47E-28 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation