YFL013W-A_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL013W-A / YFL013W-A

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.89|P-value:1.12E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.83|P-value:1.49E-8 ID:SGTC_55|Compound:0767-0285|FD-Score:4.06|P-value:5.74E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:4.60|P-value:6.31E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.32|P-value:8.25E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.87|P-value:1.22E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.44|P-value:5.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.84|P-value:2.12E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.66|P-value:4.82E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:5.29|P-value:2.48E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.24|P-value:3.12E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:4.01|P-value:7.18E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.14|P-value:4.29E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:7.74|P-value:8.42E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.09|P-value:5.12E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:9.81|P-value:4.21E-21 ID:SGTC_514|Compound:4466-0038|FD-Score:10.20|P-value:1.11E-22 ID:SGTC_642|Compound:0335-0876|FD-Score:4.26|P-value:2.58E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.47|P-value:8.60E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.41|P-value:5.01E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.69|P-value:1.22E-20 ID:SGTC_683|Compound:panaxydol|FD-Score:3.30|P-value:8.67E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.50|P-value:9.52E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:3.42|P-value:5.96E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.30|P-value:7.37E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.94|P-value:9.87E-7 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.60|P-value:3.14E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.59|P-value:2.65E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-5.43|P-value:9.01E-8 ID:SGTC_1399|Compound:3562-5772|FD-Score:5.55|P-value:6.51E-8 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-3.36|P-value:6.04E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.80|P-value:1.53E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.79|P-value:2.01E-6 ID:SGTC_1715|Compound:st032160|FD-Score:3.42|P-value:5.94E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.86|P-value:1.00E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.42|P-value:5.87E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.40|P-value:6.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.47|P-value:1.08E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.16|P-value:3.97E-5 ID:SGTC_1947|Compound:st076332|FD-Score:3.68|P-value:2.42E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.24|P-value:1.47E-9 ID:SGTC_2021|Compound:4019055|FD-Score:-3.61|P-value:2.55E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.54|P-value:8.19E-6 ID:SGTC_2078|Compound:5212016|FD-Score:-4.63|P-value:4.25E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-3.29|P-value:7.57E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.50|P-value:9.44E-6 ID:SGTC_2413|Compound:inermin|FD-Score:4.67|P-value:4.57E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.92|P-value:9.97E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.70|P-value:2.26E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.83|P-value:2.21E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.27|P-value:2.53E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.33|P-value:7.92E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.33|P-value:6.58E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.41|P-value:4.97E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.37|P-value:1.67E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.03|P-value:6.42E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.31|P-value:8.55E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.50|P-value:3.67E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.67|P-value:2.48E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.23|P-value:9.12E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.21|P-value:9.78E-4 ID:SGTC_3324|Compound:9138759|FD-Score:5.17|P-value:4.44E-7 ID:SGTC_3335|Compound:9143315|FD-Score:-3.21|P-value:9.78E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.70|P-value:2.21E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.89|P-value:1.12E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:5.83|P-value:1.49E-8 ID:SGTC_55|Compound:0767-0285|FD-Score:4.06|P-value:5.74E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:4.60|P-value:6.31E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:3.32|P-value:8.25E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.87|P-value:1.22E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.44|P-value:5.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.84|P-value:2.12E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.66|P-value:4.82E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:5.29|P-value:2.48E-7 ID:SGTC_309|Compound:k408-0051|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.24|P-value:3.12E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:4.01|P-value:7.18E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:4.14|P-value:4.29E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:7.74|P-value:8.42E-14 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.09|P-value:5.12E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:9.81|P-value:4.21E-21 ID:SGTC_514|Compound:4466-0038|FD-Score:10.20|P-value:1.11E-22 ID:SGTC_642|Compound:0335-0876|FD-Score:4.26|P-value:2.58E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.47|P-value:8.60E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.41|P-value:5.01E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.69|P-value:1.22E-20 ID:SGTC_683|Compound:panaxydol|FD-Score:3.30|P-value:8.67E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.50|P-value:9.52E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:3.42|P-value:5.96E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.30|P-value:7.37E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.94|P-value:9.87E-7 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.60|P-value:3.14E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.59|P-value:2.65E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-5.43|P-value:9.01E-8 ID:SGTC_1399|Compound:3562-5772|FD-Score:5.55|P-value:6.51E-8 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-3.36|P-value:6.04E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.80|P-value:1.53E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.79|P-value:2.01E-6 ID:SGTC_1715|Compound:st032160|FD-Score:3.42|P-value:5.94E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.86|P-value:1.00E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.42|P-value:5.87E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.40|P-value:6.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.47|P-value:1.08E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.16|P-value:3.97E-5 ID:SGTC_1947|Compound:st076332|FD-Score:3.68|P-value:2.42E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.24|P-value:1.47E-9 ID:SGTC_2021|Compound:4019055|FD-Score:-3.61|P-value:2.55E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.54|P-value:8.19E-6 ID:SGTC_2078|Compound:5212016|FD-Score:-4.63|P-value:4.25E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-3.29|P-value:7.57E-4 ID:SGTC_2369|Compound:9071472|FD-Score:4.50|P-value:9.44E-6 ID:SGTC_2413|Compound:inermin|FD-Score:4.67|P-value:4.57E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.92|P-value:9.97E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.70|P-value:2.26E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.83|P-value:2.21E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.27|P-value:2.53E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.33|P-value:7.92E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.33|P-value:6.58E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.41|P-value:4.97E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.37|P-value:1.67E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.03|P-value:6.42E-5 ID:SGTC_2907|Compound:7721985|FD-Score:3.31|P-value:8.55E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-3.50|P-value:3.67E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.67|P-value:2.48E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.23|P-value:9.12E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.21|P-value:9.78E-4 ID:SGTC_3324|Compound:9138759|FD-Score:5.17|P-value:4.44E-7 ID:SGTC_3335|Compound:9143315|FD-Score:-3.21|P-value:9.78E-4 ID:SGTC_3355|Compound:9151058|FD-Score:3.70|P-value:2.21E-4

Top fitness defect scores for YFL013W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 10.20 2.6 nM 1.11E-22 cell wall 20 9.38E-25
2 SGTC_513 4245-1575 9.81 41.7 µM 4.21E-21 unfolded protein response 17 5.03E-23
3 SGTC_682 0kpi-0099 9.69 17.0 µM 1.22E-20 6 1.61E-22
4 SGTC_361 000s-0510 7.74 1.4 µM 8.42E-14 2 5.04E-15
5 SGTC_1959 st077091 6.24 55.8 µM 1.47E-9 RPP1 & pyrimidine depletion 5 2.25E-10
6 SGTC_36 0335-0881 5.83 14.2 µM 1.49E-8 ubiquinone biosynthesis & proteasome 69 2.84E-9
7 SGTC_1399 3562-5772 5.55 25.0 µM 6.51E-8 RPP1 & pyrimidine depletion 5 1.43E-8
8 SGTC_2801 7907800 5.37 81.8 µM 1.67E-7 9 4.02E-8
9 SGTC_304 1310-0298 5.29 97.0 µM 2.48E-7 cell wall 28 6.23E-8
10 SGTC_310 1273-0058 5.24 1.1 µM 3.12E-7 mitochondrial stress 174 8.00E-8
11 SGTC_3324 9138759 5.17 60.8 µM 4.44E-7 6 1.18E-7
12 SGTC_163 1327-0036 4.84 7.5 µM 2.12E-6 69 6.54E-7
13 SGTC_2575 plumbagin 4.83 510.0 nM 2.21E-6 superoxide 22 6.85E-7
14 SGTC_2413 inermin 4.67 26.1 µM 4.57E-6 36 1.51E-6
15 SGTC_184 1494-0393 4.66 24.7 µM 4.82E-6 45 1.61E-6
16 SGTC_59 0330-0160 4.60 1.3 µM 6.31E-6 79 2.16E-6
17 SGTC_2067 5224629 4.54 34.1 µM 8.19E-6 13 2.87E-6
18 SGTC_2369 9071472 4.50 200.0 µM 9.44E-6 9 3.35E-6
19 SGTC_717 1532-0246 4.50 73.2 µM 9.52E-6 Golgi 20 3.39E-6
20 SGTC_1926 methyl fluorone black 4.47 53.6 µM 1.08E-5 DNA intercalators 46 3.88E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 6.83E-110 YFL013C IES1 hom Subunit of the INO80 chromatin remodeling complex
0.208 5.64E-34 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.204 1.05E-32 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.195 4.93E-30 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.192 5.07E-29 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.182 3.52E-26 YDL002C NHP10 hom Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
0.180 7.72E-26 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.179 2.59E-25 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.175 2.76E-24 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.171 2.14E-23 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.170 4.15E-23 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.169 9.45E-23 YER092W IES5 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
0.167 3.24E-22 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.165 6.95E-22 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.164 1.84E-21 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication