YFL015C_d

Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL015C / YFL015C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.15|P-value:4.71E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.43|P-value:1.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.28|P-value:2.81E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.29|P-value:2.74E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.26|P-value:3.11E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.03|P-value:7.16E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:2.99|P-value:8.41E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.11|P-value:5.50E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.56|P-value:9.26E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.07|P-value:6.13E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.36|P-value:2.31E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.43|P-value:1.56E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.04|P-value:7.17E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.12|P-value:5.33E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.50|P-value:1.12E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.02|P-value:7.65E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-2.95|P-value:9.26E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.08|P-value:6.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.95|P-value:1.67E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.15|P-value:4.67E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.68|P-value:4.42E-7 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.11|P-value:5.43E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.94|P-value:1.78E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.08|P-value:5.79E-4 ID:SGTC_1703|Compound:st026983|FD-Score:4.08|P-value:8.99E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.53|P-value:1.02E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.17|P-value:4.34E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.72|P-value:4.36E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.08|P-value:6.19E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.14|P-value:4.87E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.03|P-value:7.44E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.40|P-value:1.78E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.84|P-value:2.71E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.65|P-value:6.25E-5 ID:SGTC_3232|Compound:9132874|FD-Score:4.12|P-value:7.40E-6 ID:SGTC_3270|Compound:9137563|FD-Score:3.13|P-value:5.12E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.15|P-value:4.71E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.43|P-value:1.49E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.28|P-value:2.81E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:3.29|P-value:2.74E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.26|P-value:3.11E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.03|P-value:7.16E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:2.99|P-value:8.41E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:3.11|P-value:5.50E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.56|P-value:9.26E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.07|P-value:6.13E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.36|P-value:2.31E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.43|P-value:1.56E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.04|P-value:7.17E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.12|P-value:5.33E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.50|P-value:1.12E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.02|P-value:7.65E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-2.95|P-value:9.26E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.08|P-value:6.09E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.95|P-value:1.67E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.15|P-value:4.67E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.68|P-value:4.42E-7 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.54|P-value:1.02E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:3.11|P-value:5.43E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.94|P-value:1.78E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.08|P-value:5.79E-4 ID:SGTC_1703|Compound:st026983|FD-Score:4.08|P-value:8.99E-6 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.53|P-value:1.02E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.17|P-value:4.34E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.72|P-value:4.36E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.08|P-value:6.19E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.14|P-value:4.87E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.03|P-value:7.44E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.40|P-value:1.78E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.84|P-value:2.71E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.33|P-value:2.37E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.65|P-value:6.25E-5 ID:SGTC_3232|Compound:9132874|FD-Score:4.12|P-value:7.40E-6 ID:SGTC_3270|Compound:9137563|FD-Score:3.13|P-value:5.12E-4

Top fitness defect scores for YFL015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1346 1488-2224 4.68 62.4 µM 4.42E-7 15 1.45E-6
2 SGTC_612 0302-0167 4.36 22.4 µM 2.31E-6 copper-dependent oxidative stress 26 6.48E-6
3 SGTC_3232 9132874 4.12 49.5 µM 7.40E-6 RPP1 & pyrimidine depletion 11 1.87E-5
4 SGTC_1703 st026983 4.08 48.3 µM 8.99E-6 7 2.23E-5
5 SGTC_1083 didemethylchlorpromazine sulfoxide 3.95 707.4 nM 1.67E-5 redox potentiating 82 3.93E-5
6 SGTC_1524 corynanthine 3.94 62.1 µM 1.78E-5 16 4.16E-5
7 SGTC_2533 agelasine 3.84 13.7 µM 2.71E-5 ERG2 52 6.09E-5
8 SGTC_3010 9080089 3.65 71.4 µM 6.25E-5 22 1.30E-4
9 SGTC_529 4076-0302 3.56 30.3 µM 9.26E-5 mitochondrial processes 26 1.86E-4
10 SGTC_1469 k284-2957 3.54 126.0 µM 1.02E-4 17 2.03E-4
11 SGTC_743 1275-0778 3.43 158.0 µM 1.56E-4 excess fatty acid 56 2.98E-4
12 SGTC_2523 spermine 3.40 47.7 µM 1.78E-4 calcium & mitochondrial duress 42 3.38E-4
13 SGTC_2628 lathosterol 3.33 100.0 µM 2.37E-4 53 4.38E-4
14 SGTC_287 k060-0039 3.29 29.6 µM 2.74E-4 20 5.00E-4
15 SGTC_221 trifluoperazine 3.28 10.3 µM 2.81E-4 NEO1-PIK1 254 5.12E-4
16 SGTC_335 4077-0256 3.26 27.6 µM 3.11E-4 31 5.61E-4
17 SGTC_2081 5214970 3.17 32.3 µM 4.34E-4 59 7.59E-4
18 SGTC_1135 dihydrocapsaicin 3.15 536.7 nM 4.67E-4 68 8.11E-4
19 SGTC_8 0354-0001 3.15 70.0 µM 4.71E-4 128 8.19E-4
20 SGTC_2355 9061122 3.14 103.1 µM 4.87E-4 33 8.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.179 1.25E-25 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.149 4.10E-18 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.134 7.13E-15 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127 1.86E-13 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.122 1.12E-12 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.113 5.07E-11 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.113 5.36E-11 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.112 7.35E-11 YNL295W_p YNL295W_p hom Putative protein of unknown function
0.107 6.01E-10 YDR110W FOB1 hom Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
0.105 1.21E-9 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.101 5.18E-9 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.098 1.20E-8 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.095 3.28E-8 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.092 8.39E-8 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.090 1.52E-7 YHL030W ECM29 hom Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress