HIPHOP chemogenomics database
YFL017C / GNA1 
Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YFL017C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.107 | 5.00E-10 | YBL068W | PRS4 | hom | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication |
| 0.105 | 1.02E-9 | YIR044C | YIR044C | hom | Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family |
| 0.098 | 1.47E-8 | YDR030C | RAD28 | hom | Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair |
| 0.093 | 7.32E-8 | YML025C | YML6 | het | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins |
| 0.092 | 8.58E-8 | YOR023C | AHC1 | hom | Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex |
| 0.090 | 1.86E-7 | YFL050C | ALR2 | hom | Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition |
| 0.090 | 1.90E-7 | YFL003C | MSH4 | hom | Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein |
| 0.085 | 7.98E-7 | YER066C-A_d | YER066C-A_d | hom | Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W |
| 0.083 | 1.64E-6 | YLR225C_p | YLR225C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene |
| 0.082 | 2.00E-6 | YPL147W | PXA1 | hom | Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder |
| 0.081 | 2.84E-6 | YDR054C | CDC34 | het | Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress |
| 0.080 | 3.31E-6 | YBR150C | TBS1 | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication |
| 0.079 | 4.74E-6 | YHR003C | YHR003C | hom | Protein of unknown function, localized to the mitochondrial outer membrane |
| 0.078 | 6.81E-6 | YPR176C | BET2 | het | Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p |
| 0.077 | 7.75E-6 | YGR152C | RSR1 | hom | GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases |