YFL017C / GNA1

Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL017C / GNA1

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:3.71|P-value:6.36E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:4.12|P-value:1.04E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.20|P-value:4.68E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.49|P-value:1.57E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.82|P-value:3.88E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:6.23|P-value:5.99E-11 ID:SGTC_333|Compound:3486-0131|FD-Score:3.71|P-value:6.35E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:3.26|P-value:3.73E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.03|P-value:8.61E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.81|P-value:4.15E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.41|P-value:2.42E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:3.20|P-value:4.71E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.64|P-value:8.10E-7 ID:SGTC_705|Compound:1124-0212|FD-Score:5.79|P-value:1.08E-9 ID:SGTC_953|Compound:1188-0045|FD-Score:3.20|P-value:4.73E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.32|P-value:2.84E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.13|P-value:6.18E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.79|P-value:4.53E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.34|P-value:1.70E-8 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.20|P-value:4.81E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.72|P-value:5.99E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.89|P-value:2.88E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.95|P-value:1.58E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.39|P-value:2.17E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-4.60|P-value:9.26E-7 ID:SGTC_1673|Compound:st016611|FD-Score:3.81|P-value:4.05E-5 ID:SGTC_1678|Compound:st019265|FD-Score:3.11|P-value:6.63E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.37|P-value:2.53E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.21|P-value:4.61E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-4.59|P-value:9.38E-7 ID:SGTC_1995|Compound:st072814|FD-Score:3.09|P-value:7.17E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.72|P-value:5.69E-5 ID:SGTC_2180|Compound:6301957|FD-Score:4.21|P-value:6.66E-6 ID:SGTC_2245|Compound:6637752|FD-Score:3.42|P-value:2.08E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.07|P-value:7.65E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-4.21|P-value:6.30E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.69|P-value:6.71E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.07|P-value:7.56E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.04|P-value:1.41E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-9.52|P-value:2.96E-23 ID:SGTC_2694|Compound:st077685|FD-Score:-4.90|P-value:1.84E-7 ID:SGTC_2709|Compound:st078560|FD-Score:3.97|P-value:2.02E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.95|P-value:2.07E-5 ID:SGTC_2997|Compound:9067075|FD-Score:3.26|P-value:3.76E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.48|P-value:5.20E-15 ID:SGTC_3029|Compound:9088683|FD-Score:4.81|P-value:3.31E-7 ID:SGTC_3105|Compound:9121040|FD-Score:3.63|P-value:8.88E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.03|P-value:1.56E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.11|P-value:6.11E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.71|P-value:6.36E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:4.12|P-value:1.04E-5 ID:SGTC_133|Compound:0724-0033|FD-Score:3.20|P-value:4.68E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.49|P-value:1.57E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.82|P-value:3.88E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:6.23|P-value:5.99E-11 ID:SGTC_333|Compound:3486-0131|FD-Score:3.71|P-value:6.35E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:3.26|P-value:3.73E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.03|P-value:8.61E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:3.81|P-value:4.15E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.41|P-value:2.42E-6 ID:SGTC_632|Compound:0781-2353|FD-Score:3.20|P-value:4.71E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:4.64|P-value:8.10E-7 ID:SGTC_705|Compound:1124-0212|FD-Score:5.79|P-value:1.08E-9 ID:SGTC_953|Compound:1188-0045|FD-Score:3.20|P-value:4.73E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.32|P-value:2.84E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.13|P-value:6.18E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.79|P-value:4.53E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:5.34|P-value:1.70E-8 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.20|P-value:4.81E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.72|P-value:5.99E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.89|P-value:2.88E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.95|P-value:1.58E-7 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.39|P-value:2.17E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-4.60|P-value:9.26E-7 ID:SGTC_1673|Compound:st016611|FD-Score:3.81|P-value:4.05E-5 ID:SGTC_1678|Compound:st019265|FD-Score:3.11|P-value:6.63E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.37|P-value:2.53E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.21|P-value:4.61E-4 ID:SGTC_1993|Compound:st073995|FD-Score:-4.59|P-value:9.38E-7 ID:SGTC_1995|Compound:st072814|FD-Score:3.09|P-value:7.17E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.72|P-value:5.69E-5 ID:SGTC_2180|Compound:6301957|FD-Score:4.21|P-value:6.66E-6 ID:SGTC_2245|Compound:6637752|FD-Score:3.42|P-value:2.08E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.07|P-value:7.65E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-4.21|P-value:6.30E-6 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.69|P-value:6.71E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.07|P-value:7.56E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.04|P-value:1.41E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:-9.52|P-value:2.96E-23 ID:SGTC_2694|Compound:st077685|FD-Score:-4.90|P-value:1.84E-7 ID:SGTC_2709|Compound:st078560|FD-Score:3.97|P-value:2.02E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.95|P-value:2.07E-5 ID:SGTC_2997|Compound:9067075|FD-Score:3.26|P-value:3.76E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.48|P-value:5.20E-15 ID:SGTC_3029|Compound:9088683|FD-Score:4.81|P-value:3.31E-7 ID:SGTC_3105|Compound:9121040|FD-Score:3.63|P-value:8.88E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.03|P-value:1.56E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-3.11|P-value:6.11E-4

Top fitness defect scores for YFL017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2998 9066762 7.48 71.4 µM 5.20E-15 RPP1 & pyrimidine depletion 1 3.85E-14 1.06
2 SGTC_165 k038-0023 6.23 64.4 µM 5.99E-11 ubiquinone biosynthesis & proteasome 9 2.40E-10 0.86
3 SGTC_705 1124-0212 5.79 310.0 µM 1.08E-9 1 3.60E-9 0.90
4 SGTC_1324 1418-0026 5.34 34.4 µM 1.70E-8 1 4.72E-8 1.00
5 SGTC_1361 1608-0041 4.95 5.6 µM 1.58E-7 RPP1 & pyrimidine depletion 2 3.80E-7 0.34
6 SGTC_3029 9088683 4.81 49.5 µM 3.31E-7 1 7.60E-7 0.52
7 SGTC_676 falcarinol 4.64 140.0 µM 8.10E-7 7 1.76E-6 0.20
8 SGTC_2180 6301957 4.21 200.0 µM 6.66E-6 RSC complex & mRNA processing 9 1.26E-5 0.09
9 SGTC_95 0471-0001 4.12 561.1 µM 1.04E-5 4 1.91E-5 0.33
10 SGTC_3108 9121785 4.03 49.5 µM 1.56E-5 11 2.80E-5 0.07
11 SGTC_2709 st078560 3.97 56.0 µM 2.02E-5 6 3.56E-5 0.22
12 SGTC_1347 1493-0251 3.89 600.0 nM 2.88E-5 mitochondrial response to ROS 6 4.97E-5 0.07
13 SGTC_139 0099-0334 3.82 718.6 µM 3.88E-5 7 6.59E-5 0.06
14 SGTC_1673 st016611 3.81 27.3 µM 4.05E-5 7 6.86E-5 0.22
15 SGTC_505 gw-5074 3.81 63.9 µM 4.15E-5 7 7.02E-5 0.02
16 SGTC_1306 1185-0270 3.79 9.0 µM 4.53E-5 Golgi 12 7.61E-5 0.07
17 SGTC_1345 1488-0192 3.72 31.4 µM 5.99E-5 2 9.89E-5 0.07
18 SGTC_333 3486-0131 3.71 40.1 µM 6.35E-5 amide catabolism 4 1.04E-4 0.15
19 SGTC_81 0411-0046 3.71 10.0 µM 6.36E-5 41 1.05E-4 0.03
20 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.69 63.6 µM 6.71E-5 12 1.10E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.00E-10 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.105 1.02E-9 YIR044C YIR044C hom Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
0.098 1.47E-8 YDR030C RAD28 hom Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
0.093 7.32E-8 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.092 8.58E-8 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.090 1.86E-7 YFL050C ALR2 hom Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
0.090 1.90E-7 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.085 7.98E-7 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.083 1.64E-6 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.082 2.00E-6 YPL147W PXA1 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.081 2.84E-6 YDR054C CDC34 het Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.080 3.31E-6 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.079 4.74E-6 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.078 6.81E-6 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.077 7.75E-6 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases