YFL017W-A / SMX2

Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL017W-A / SMX2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:3.05|P-value:5.38E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.06|P-value:5.10E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.95|P-value:8.02E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:2.99|P-value:6.94E-4 ID:SGTC_263|Compound:alizarin|FD-Score:2.95|P-value:7.83E-4 ID:SGTC_269|Compound:exalamide|FD-Score:5.32|P-value:6.12E-9 ID:SGTC_375|Compound:3970-0961|FD-Score:3.20|P-value:3.04E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.05|P-value:5.47E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.43|P-value:1.16E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.54|P-value:7.21E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.02|P-value:6.06E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.22|P-value:2.87E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.74|P-value:1.80E-7 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.10|P-value:4.32E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.94|P-value:1.22E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.86|P-value:1.77E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.06|P-value:5.15E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.16|P-value:3.60E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.28|P-value:2.10E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.01|P-value:6.42E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-2.91|P-value:8.85E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.52|P-value:8.31E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:5.27|P-value:8.41E-9 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.24|P-value:2.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.73|P-value:3.17E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:2.94|P-value:8.24E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.19|P-value:3.12E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.18|P-value:3.19E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.03|P-value:5.94E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.51|P-value:8.68E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.21|P-value:2.89E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.64|P-value:4.57E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.62|P-value:5.28E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-3.19|P-value:3.05E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.52|P-value:7.72E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.28|P-value:2.19E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-4.01|P-value:8.15E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.01|P-value:8.86E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-3.42|P-value:1.20E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-4.45|P-value:8.87E-7 ID:SGTC_2798|Compound:7813637|FD-Score:-3.76|P-value:2.68E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.70|P-value:3.69E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.46|P-value:1.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.10|P-value:4.41E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.97|P-value:7.08E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.41|P-value:1.31E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.99|P-value:6.91E-4 ID:SGTC_2999|Compound:9069765|FD-Score:5.21|P-value:1.16E-8 ID:SGTC_3074|Compound:9116018|FD-Score:-2.91|P-value:8.82E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.85|P-value:1.88E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.08|P-value:4.81E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.17|P-value:3.44E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.00|P-value:9.03E-6 ID:SGTC_3229|Compound:9132204|FD-Score:-2.94|P-value:7.89E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.81|P-value:1.30E-7 ID:SGTC_3252|Compound:9135871|FD-Score:3.60|P-value:5.86E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-2.96|P-value:7.43E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.05|P-value:5.38E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.06|P-value:5.10E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.95|P-value:8.02E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:2.99|P-value:6.94E-4 ID:SGTC_263|Compound:alizarin|FD-Score:2.95|P-value:7.83E-4 ID:SGTC_269|Compound:exalamide|FD-Score:5.32|P-value:6.12E-9 ID:SGTC_375|Compound:3970-0961|FD-Score:3.20|P-value:3.04E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.05|P-value:5.47E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.43|P-value:1.16E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.54|P-value:7.21E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.02|P-value:6.06E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.22|P-value:2.87E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.74|P-value:1.80E-7 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.10|P-value:4.32E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.94|P-value:1.22E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.86|P-value:1.77E-5 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.06|P-value:5.15E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.16|P-value:3.60E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.43|P-value:1.19E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.28|P-value:2.10E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.01|P-value:6.42E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-2.91|P-value:8.85E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.52|P-value:8.31E-5 ID:SGTC_1409|Compound:3909-8004|FD-Score:5.27|P-value:8.41E-9 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.24|P-value:2.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.73|P-value:3.17E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:2.94|P-value:8.24E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.19|P-value:3.12E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.18|P-value:3.19E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.03|P-value:5.94E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.51|P-value:8.68E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.21|P-value:2.89E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.64|P-value:4.57E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.62|P-value:5.28E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-3.19|P-value:3.05E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.52|P-value:7.72E-5 ID:SGTC_2479|Compound:5617353|FD-Score:3.28|P-value:2.19E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-4.01|P-value:8.15E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.01|P-value:8.86E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-3.42|P-value:1.20E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-4.45|P-value:8.87E-7 ID:SGTC_2798|Compound:7813637|FD-Score:-3.76|P-value:2.68E-5 ID:SGTC_2799|Compound:7812892|FD-Score:3.70|P-value:3.69E-5 ID:SGTC_2817|Compound:7995342|FD-Score:-3.46|P-value:1.02E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.10|P-value:4.41E-4 ID:SGTC_2824|Compound:7998404|FD-Score:-2.97|P-value:7.08E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.41|P-value:1.31E-4 ID:SGTC_2995|Compound:9067767|FD-Score:2.99|P-value:6.91E-4 ID:SGTC_2999|Compound:9069765|FD-Score:5.21|P-value:1.16E-8 ID:SGTC_3074|Compound:9116018|FD-Score:-2.91|P-value:8.82E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.85|P-value:1.88E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.08|P-value:4.81E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.17|P-value:3.44E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.00|P-value:9.03E-6 ID:SGTC_3229|Compound:9132204|FD-Score:-2.94|P-value:7.89E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.81|P-value:1.30E-7 ID:SGTC_3252|Compound:9135871|FD-Score:3.60|P-value:5.86E-5 ID:SGTC_3290|Compound:9121031|FD-Score:-2.96|P-value:7.43E-4

Top fitness defect scores for YFL017W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_269 exalamide 5.32 29.0 µM 6.12E-9 ergosterol biosynthesis 3 5.31E-8 1.25
2 SGTC_1409 3909-8004 5.27 61.9 µM 8.41E-9 2 7.01E-8 1.24
3 SGTC_2999 9069765 5.21 71.4 µM 1.16E-8 amide catabolism 1 9.28E-8 1.35
4 SGTC_3242 9133940 4.81 49.5 µM 1.30E-7 1 7.67E-7 0.59
5 SGTC_2581 avocatin a 4.01 64.0 µM 8.86E-6 sphingolipid biosynthesis & PDR1 6 3.08E-5 0.07
6 SGTC_3208 9114115 4.00 49.5 µM 9.03E-6 12 3.14E-5 0.07
7 SGTC_1030 k029-0042 3.94 36.7 µM 1.22E-5 TSC3-RPN4 4 4.08E-5 0.08
8 SGTC_1033 k072-0102 3.86 21.3 µM 1.77E-5 60S ribosome export 6 5.67E-5 0.23
9 SGTC_3075 9116269 3.85 49.5 µM 1.88E-5 7 5.96E-5 0.00
10 SGTC_1635 st007035 3.73 42.4 µM 3.17E-5 23 9.42E-5 0.00
11 SGTC_2799 7812892 3.70 81.8 µM 3.69E-5 superoxide 19 1.08E-4 0.05
12 SGTC_2164 5685496 3.62 200.0 µM 5.28E-5 10 1.47E-4 0.24
13 SGTC_3252 9135871 3.60 49.5 µM 5.86E-5 7 1.62E-4 0.12
14 SGTC_1404 3909-7820 3.52 48.3 µM 8.31E-5 60S ribosome export 6 2.20E-4 0.18
15 SGTC_2027 5150920 3.51 200.0 µM 8.68E-5 4 2.28E-4 0.18
16 SGTC_1061 3448-9325 3.43 110.0 µM 1.19E-4 11 3.01E-4 0.07
17 SGTC_2937 9044753 3.41 11.3 µM 1.31E-4 60S ribosome export 13 3.28E-4 0.07
18 SGTC_2479 5617353 3.28 43.9 µM 2.19E-4 17 5.15E-4 0.03
19 SGTC_1416 3966-0321 3.24 25.3 µM 2.57E-4 12 5.91E-4 0.23
20 SGTC_761 k216-0224 3.22 480.0 µM 2.87E-4 14 6.52E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 6.38E-18 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.141 2.97E-16 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.114 3.05E-11 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.100 6.62E-9 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
0.098 1.53E-8 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.097 1.70E-8 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.096 2.56E-8 YER137C_p YER137C_p hom Putative protein of unknown function
0.095 3.10E-8 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.093 5.80E-8 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.092 8.01E-8 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.088 3.69E-7 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.087 4.30E-7 YOR239W ABP140 hom AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
0.084 1.07E-6 YKR044W UIP5 hom Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
0.082 2.04E-6 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.080 3.19E-6 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data