YFL018C / LPD1

Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL018C / LPD1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:5.78|P-value:4.04E-8 ID:SGTC_34|Compound:0469-0683|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:7.37|P-value:4.75E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.56|P-value:1.07E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:4.07|P-value:7.12E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:6.15|P-value:5.85E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:4.05|P-value:7.66E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:6.10|P-value:7.53E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.45|P-value:5.95E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.96|P-value:1.05E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.21|P-value:4.25E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:15.40|P-value:1.15E-45 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.20|P-value:6.64E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:5.37|P-value:3.08E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:3.92|P-value:1.24E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.51|P-value:9.14E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.29|P-value:3.14E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.17|P-value:9.96E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.79|P-value:3.75E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.71|P-value:4.83E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.49|P-value:5.33E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.50|P-value:9.47E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.54|P-value:1.13E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.39|P-value:7.26E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.70|P-value:5.04E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.38|P-value:7.56E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.45|P-value:5.95E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.63|P-value:3.35E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.97|P-value:1.85E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.35|P-value:8.18E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:5.11E-30 ID:SGTC_1687|Compound:st020778|FD-Score:6.62|P-value:4.26E-10 ID:SGTC_1694|Compound:st024011|FD-Score:3.88|P-value:1.41E-4 ID:SGTC_1696|Compound:st025591|FD-Score:6.99|P-value:4.86E-11 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.94|P-value:1.14E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.40|P-value:2.66E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.06|P-value:9.46E-9 ID:SGTC_1935|Compound:st074532|FD-Score:4.93|P-value:2.26E-6 ID:SGTC_1974|Compound:st069448|FD-Score:-3.88|P-value:2.80E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.61|P-value:3.56E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.67|P-value:2.90E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.66|P-value:3.06E-4 ID:SGTC_2241|Compound:6772625|FD-Score:6.71|P-value:2.59E-10 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.67|P-value:5.51E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.49|P-value:1.42E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.97|P-value:2.06E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.68|P-value:2.86E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.00|P-value:9.10E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.62|P-value:6.55E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.39|P-value:2.13E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.97|P-value:1.85E-6 ID:SGTC_3299|Compound:9121982|FD-Score:3.41|P-value:6.85E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:5.78|P-value:4.04E-8 ID:SGTC_34|Compound:0469-0683|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:7.37|P-value:4.75E-12 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.56|P-value:1.07E-5 ID:SGTC_54|Compound:0159-0055|FD-Score:4.07|P-value:7.12E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:6.15|P-value:5.85E-9 ID:SGTC_116|Compound:0155-0182|FD-Score:4.05|P-value:7.66E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:6.10|P-value:7.53E-9 ID:SGTC_141|Compound:0443-0274|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.45|P-value:5.95E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:3.96|P-value:1.05E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.21|P-value:4.25E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:15.40|P-value:1.15E-45 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.20|P-value:6.64E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:5.37|P-value:3.08E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:3.92|P-value:1.24E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.51|P-value:9.14E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.29|P-value:3.14E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.17|P-value:9.96E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.79|P-value:3.75E-4 ID:SGTC_809|Compound:3998-0021|FD-Score:-3.71|P-value:4.83E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.49|P-value:5.33E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.50|P-value:9.47E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.54|P-value:1.13E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.39|P-value:7.26E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.70|P-value:5.04E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.38|P-value:7.56E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.45|P-value:5.95E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.63|P-value:3.35E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.97|P-value:1.85E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.35|P-value:8.18E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.30|P-value:5.11E-30 ID:SGTC_1687|Compound:st020778|FD-Score:6.62|P-value:4.26E-10 ID:SGTC_1694|Compound:st024011|FD-Score:3.88|P-value:1.41E-4 ID:SGTC_1696|Compound:st025591|FD-Score:6.99|P-value:4.86E-11 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.94|P-value:1.14E-4 ID:SGTC_1866|Compound:st057638|FD-Score:5.40|P-value:2.66E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.06|P-value:9.46E-9 ID:SGTC_1935|Compound:st074532|FD-Score:4.93|P-value:2.26E-6 ID:SGTC_1974|Compound:st069448|FD-Score:-3.88|P-value:2.80E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.61|P-value:3.56E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.67|P-value:2.90E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.66|P-value:3.06E-4 ID:SGTC_2241|Compound:6772625|FD-Score:6.71|P-value:2.59E-10 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.67|P-value:5.51E-4 ID:SGTC_2834|Compound:9001755|FD-Score:4.49|P-value:1.42E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-3.97|P-value:2.06E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.68|P-value:2.86E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.00|P-value:9.10E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.62|P-value:6.55E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.39|P-value:2.13E-5 ID:SGTC_3254|Compound:9136651|FD-Score:4.97|P-value:1.85E-6 ID:SGTC_3299|Compound:9121982|FD-Score:3.41|P-value:6.85E-4

Top fitness defect scores for YFL018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 15.40 5.3 µM 1.15E-45 96 9.56E-54
2 SGTC_1635 st007035 12.30 42.4 µM 5.11E-30 57 4.15E-35
3 SGTC_36 0335-0881 7.37 14.2 µM 4.75E-12 ubiquinone biosynthesis & proteasome 43 8.69E-14
4 SGTC_1696 st025591 6.99 34.8 µM 4.86E-11 SWF1 & branched chain AA biosynthesis 8 1.35E-12
5 SGTC_2241 6772625 6.71 37.8 µM 2.59E-10 5 9.77E-12
6 SGTC_1687 st020778 6.62 55.4 µM 4.26E-10 96 1.75E-11
7 SGTC_59 0330-0160 6.15 1.3 µM 5.85E-9 36 3.84E-10
8 SGTC_134 0269-0018 6.10 6.9 µM 7.53E-9 82 5.16E-10
9 SGTC_1877 wortmannin 6.06 25.0 µM 9.46E-9 45 6.76E-10
10 SGTC_7 0192-1582 5.78 4.2 µM 4.04E-8 26 3.73E-9
11 SGTC_1866 st057638 5.40 64.0 µM 2.66E-7 3 3.41E-8
12 SGTC_279 1273-0055 5.37 2.9 µM 3.08E-7 azole & statin 20 4.05E-8
13 SGTC_275 trichlorophene 5.20 5.7 µM 6.64E-7 mitochondrial stress 156 9.98E-8
14 SGTC_1495 4469-0029 4.97 237.0 µM 1.85E-6 71 3.32E-7
15 SGTC_3254 9136651 4.97 49.5 µM 1.85E-6 DNA damage response 8 3.32E-7
16 SGTC_1935 st074532 4.93 41.6 µM 2.26E-6 10 4.19E-7
17 SGTC_46 0329-0187a 4.56 2.2 µM 1.07E-5 52 2.58E-6
18 SGTC_902 1120-0002 4.54 2.1 µM 1.13E-5 azole & statin 32 2.76E-6
19 SGTC_2834 9001755 4.49 58.4 µM 1.42E-5 24 3.60E-6
20 SGTC_3208 9114115 4.39 49.5 µM 2.13E-5 25 5.78E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.461 3.11E-176 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.459 1.26E-174 YER061C CEM1 hom Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
0.451 1.03E-167 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.451 1.43E-167 YOR196C LIP5 hom Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
0.444 4.01E-162 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.442 2.92E-160 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.437 1.96E-156 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.436 4.18E-156 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.435 1.06E-154 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.432 1.12E-152 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.429 2.48E-150 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.427 1.59E-148 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.426 2.14E-148 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.426 4.90E-148 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.420 2.44E-143 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p