YFL019C_d

Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL019C / YFL019C

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-2.75|P-value:9.61E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.72|P-value:5.33E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:2.91|P-value:5.49E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.62|P-value:2.53E-5 ID:SGTC_271|Compound:rotenone|FD-Score:-3.09|P-value:2.48E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:5.22|P-value:2.46E-9 ID:SGTC_282|Compound:k297-0036|FD-Score:3.42|P-value:6.38E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:5.31|P-value:1.29E-9 ID:SGTC_358|Compound:0075-0058|FD-Score:4.36|P-value:4.95E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:3.33|P-value:9.43E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.17|P-value:1.89E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.09|P-value:2.21E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:3.51|P-value:4.12E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.03|P-value:3.22E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.96|P-value:4.51E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:3.02|P-value:3.50E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.31|P-value:1.06E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.17|P-value:1.89E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.96|P-value:4.46E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.13|P-value:2.27E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.23|P-value:1.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.64|P-value:2.22E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.60|P-value:2.78E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.42|P-value:3.63E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.98|P-value:3.68E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.97|P-value:1.22E-8 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.25|P-value:1.33E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.05|P-value:2.96E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.87|P-value:7.11E-6 ID:SGTC_1726|Compound:st035556|FD-Score:-2.76|P-value:9.30E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.42|P-value:5.90E-10 ID:SGTC_1752|Compound:st044819|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.02|P-value:3.30E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.85|P-value:7.79E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.24|P-value:1.39E-4 ID:SGTC_1954|Compound:st077032|FD-Score:2.86|P-value:6.81E-4 ID:SGTC_2067|Compound:5224629|FD-Score:2.79|P-value:9.04E-4 ID:SGTC_2078|Compound:5212016|FD-Score:3.63|P-value:2.33E-5 ID:SGTC_2104|Compound:5389443|FD-Score:2.96|P-value:4.62E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.09|P-value:2.69E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.47|P-value:4.70E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.61|P-value:2.55E-5 ID:SGTC_2318|Compound:6029776|FD-Score:2.91|P-value:5.47E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.88|P-value:6.71E-6 ID:SGTC_2425|Compound:5628681|FD-Score:-2.90|P-value:5.37E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.04|P-value:8.11E-9 ID:SGTC_2434|Compound:5670830|FD-Score:3.50|P-value:4.42E-5 ID:SGTC_2438|Compound:5259590|FD-Score:2.76|P-value:9.76E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.81|P-value:9.87E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:3.96|P-value:4.62E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-5.05|P-value:6.79E-9 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:6.19|P-value:1.95E-12 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.03|P-value:3.47E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:2.95|P-value:4.68E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-2.78|P-value:8.55E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.90|P-value:6.08E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.04|P-value:3.33E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.23|P-value:1.50E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.12|P-value:1.97E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:6.19|P-value:1.88E-12 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.31|P-value:1.04E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.18|P-value:1.87E-4 ID:SGTC_2875|Compound:9039966|FD-Score:2.85|P-value:7.14E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.80|P-value:3.69E-8 ID:SGTC_2911|Compound:7942208|FD-Score:3.19|P-value:1.77E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.74|P-value:1.36E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-3.05|P-value:2.95E-4 ID:SGTC_3089|Compound:9117425|FD-Score:2.86|P-value:6.72E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.08|P-value:2.83E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-2.81|P-value:7.64E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.70|P-value:6.87E-8 ID:SGTC_44|Compound:0929-0055|FD-Score:-2.75|P-value:9.61E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.72|P-value:5.33E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:2.91|P-value:5.49E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.62|P-value:2.53E-5 ID:SGTC_271|Compound:rotenone|FD-Score:-3.09|P-value:2.48E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:5.22|P-value:2.46E-9 ID:SGTC_282|Compound:k297-0036|FD-Score:3.42|P-value:6.38E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:5.31|P-value:1.29E-9 ID:SGTC_358|Compound:0075-0058|FD-Score:4.36|P-value:4.95E-7 ID:SGTC_365|Compound:0121-0052|FD-Score:3.33|P-value:9.43E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.17|P-value:1.89E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:4.09|P-value:2.21E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:3.51|P-value:4.12E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.03|P-value:3.22E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.96|P-value:4.51E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:3.02|P-value:3.50E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.31|P-value:1.06E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.17|P-value:1.89E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.96|P-value:4.46E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.24|P-value:1.41E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.13|P-value:2.27E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.23|P-value:1.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.64|P-value:2.22E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.60|P-value:2.78E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.42|P-value:3.63E-7 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.98|P-value:3.68E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.97|P-value:1.22E-8 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.25|P-value:1.33E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.05|P-value:2.96E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.87|P-value:7.11E-6 ID:SGTC_1726|Compound:st035556|FD-Score:-2.76|P-value:9.30E-4 ID:SGTC_1727|Compound:st034309|FD-Score:5.42|P-value:5.90E-10 ID:SGTC_1752|Compound:st044819|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.02|P-value:3.30E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.85|P-value:7.79E-6 ID:SGTC_1939|Compound:st074455|FD-Score:3.24|P-value:1.39E-4 ID:SGTC_1954|Compound:st077032|FD-Score:2.86|P-value:6.81E-4 ID:SGTC_2067|Compound:5224629|FD-Score:2.79|P-value:9.04E-4 ID:SGTC_2078|Compound:5212016|FD-Score:3.63|P-value:2.33E-5 ID:SGTC_2104|Compound:5389443|FD-Score:2.96|P-value:4.62E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.09|P-value:2.69E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.47|P-value:4.70E-5 ID:SGTC_2290|Compound:7904846|FD-Score:3.61|P-value:2.55E-5 ID:SGTC_2318|Compound:6029776|FD-Score:2.91|P-value:5.47E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.88|P-value:6.71E-6 ID:SGTC_2425|Compound:5628681|FD-Score:-2.90|P-value:5.37E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.04|P-value:8.11E-9 ID:SGTC_2434|Compound:5670830|FD-Score:3.50|P-value:4.42E-5 ID:SGTC_2438|Compound:5259590|FD-Score:2.76|P-value:9.76E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.81|P-value:9.87E-6 ID:SGTC_2513|Compound:baicalein|FD-Score:3.96|P-value:4.62E-6 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-5.05|P-value:6.79E-9 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:6.19|P-value:1.95E-12 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.03|P-value:3.47E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:2.95|P-value:4.68E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-2.78|P-value:8.55E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.90|P-value:6.08E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.04|P-value:3.33E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.23|P-value:1.50E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.12|P-value:1.97E-6 ID:SGTC_2750|Compound:bromebric acid|FD-Score:6.19|P-value:1.88E-12 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.31|P-value:1.04E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.18|P-value:1.87E-4 ID:SGTC_2875|Compound:9039966|FD-Score:2.85|P-value:7.14E-4 ID:SGTC_2905|Compound:7799065|FD-Score:4.80|P-value:3.69E-8 ID:SGTC_2911|Compound:7942208|FD-Score:3.19|P-value:1.77E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.74|P-value:1.36E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-3.05|P-value:2.95E-4 ID:SGTC_3089|Compound:9117425|FD-Score:2.86|P-value:6.72E-4 ID:SGTC_3092|Compound:9117248|FD-Score:3.08|P-value:2.83E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-2.81|P-value:7.64E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.70|P-value:6.87E-8

Top fitness defect scores for YFL019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2750 bromebric acid 6.19 70.2 µM 1.88E-12 4 2.98E-10
2 SGTC_2536 dehydroabietamide 6.19 32.0 µM 1.95E-12 3 3.07E-10
3 SGTC_1727 st034309 5.42 9.9 µM 5.90E-10 13 2.93E-8
4 SGTC_306 1672-3436 5.31 11.6 µM 1.29E-9 Golgi 4 5.46E-8
5 SGTC_280 3448-3607 5.22 3.0 µM 2.46E-9 60S ribosome export 1 9.19E-8
6 SGTC_2428 5615643 5.04 7.8 µM 8.11E-9 18 2.38E-7
7 SGTC_1381 2324-0066 4.97 62.1 µM 1.22E-8 13 3.30E-7
8 SGTC_2905 7799065 4.80 20.1 µM 3.69E-8 6 7.99E-7
9 SGTC_3232 9132874 4.70 49.5 µM 6.87E-8 RPP1 & pyrimidine depletion 7 1.31E-6
10 SGTC_1308 1187-1617 4.42 41.4 µM 3.63E-7 fatty acid desaturase (OLE1) 26 4.98E-6
11 SGTC_358 0075-0058 4.36 9.4 µM 4.95E-7 46 6.39E-6
12 SGTC_2749 bexarotene 4.12 57.4 µM 1.97E-6 18 1.93E-5
13 SGTC_479 n-linoleoylglycine 4.09 10.0 µM 2.21E-6 9 2.12E-5
14 SGTC_1036 k216-0215 3.96 33.5 µM 4.46E-6 mitochondrial response to ROS 50 3.72E-5
15 SGTC_917 harmaline 3.96 728.1 nM 4.51E-6 ergosterol biosynthesis 27 3.75E-5
16 SGTC_2513 baicalein 3.96 25.6 µM 4.62E-6 calcium & mitochondrial duress 28 3.83E-5
17 SGTC_2658 polymyxin b sulfate 3.90 77.0 µM 6.08E-6 NEO1 40 4.77E-5
18 SGTC_2341 7987486 3.88 176.7 µM 6.71E-6 18 5.16E-5
19 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.87 67.5 µM 7.11E-6 46 5.41E-5
20 SGTC_1885 st057546 3.85 99.9 µM 7.79E-6 24 5.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.03E-8 YOL098C_p YOL098C_p hom Putative metalloprotease
0.095 3.77E-8 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.086 5.43E-7 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.086 5.58E-7 YDR115W YDR115W hom Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress
0.084 1.23E-6 YNL089C_d YNL089C_d hom Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
0.082 1.77E-6 YJL181W_p YJL181W_p hom Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication
0.082 2.27E-6 YOR256C TRE2 het Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
0.081 2.80E-6 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.081 2.88E-6 YGR123C PPT1 hom Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
0.080 3.40E-6 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.079 4.19E-6 YAL049C AIM2 hom Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor
0.079 4.35E-6 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.079 5.25E-6 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.078 6.78E-6 YAL059W ECM1 hom Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
0.076 9.25E-6 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel