HIPHOP chemogenomics database
YFL019C_d 
Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YFL019C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.095 | 3.03E-8 | YOL098C_p | YOL098C_p | hom | Putative metalloprotease |
| 0.095 | 3.77E-8 | YMR305C | SCW10 | hom | Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p |
| 0.086 | 5.43E-7 | YBR264C | YPT10 | hom | Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles |
| 0.086 | 5.58E-7 | YDR115W | YDR115W | hom | Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress |
| 0.084 | 1.23E-6 | YNL089C_d | YNL089C_d | hom | Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins |
| 0.082 | 1.77E-6 | YJL181W_p | YJL181W_p | hom | Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication |
| 0.082 | 2.27E-6 | YOR256C | TRE2 | het | Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication |
| 0.081 | 2.80E-6 | YBL029W_p | YBL029W_p | hom | Non-essential protein of unknown function |
| 0.081 | 2.88E-6 | YGR123C | PPT1 | hom | Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth |
| 0.080 | 3.40E-6 | YOL071W | EMI5 | hom | Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) |
| 0.079 | 4.19E-6 | YAL049C | AIM2 | hom | Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor |
| 0.079 | 4.35E-6 | YDR021W | FAL1 | het | Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases |
| 0.079 | 5.25E-6 | YBR048W | RPS11B | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication |
| 0.078 | 6.78E-6 | YAL059W | ECM1 | hom | Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm |
| 0.076 | 9.25E-6 | YPL063W | TIM50 | het | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel |