YFL024C / EPL1

Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL024C / EPL1

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.14|P-value:7.14E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.29|P-value:4.43E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.16|P-value:1.19E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.55|P-value:1.56E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.98|P-value:2.67E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:4.43|P-value:3.45E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.30|P-value:4.34E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:10.50|P-value:1.35E-26 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.46|P-value:2.40E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.51|P-value:2.27E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.07|P-value:9.16E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:5.12|P-value:9.81E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.80|P-value:6.13E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.78|P-value:6.78E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.64|P-value:1.19E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.90|P-value:3.74E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.67|P-value:9.81E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.54|P-value:1.76E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.29|P-value:4.12E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.54|P-value:1.96E-6 ID:SGTC_1602|Compound:st001878|FD-Score:3.42|P-value:2.58E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.55|P-value:1.64E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.84|P-value:1.50E-9 ID:SGTC_1715|Compound:st032160|FD-Score:3.82|P-value:5.12E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:5.53|P-value:1.02E-8 ID:SGTC_1723|Compound:st034307|FD-Score:-3.58|P-value:1.50E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.55|P-value:1.54E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.99|P-value:2.72E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.09|P-value:8.42E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.30|P-value:5.58E-36 ID:SGTC_1903|Compound:st060211|FD-Score:3.23|P-value:5.11E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.06|P-value:9.30E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.17|P-value:6.36E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.78|P-value:6.11E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.30|P-value:3.96E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.71|P-value:8.08E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.59|P-value:1.34E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.87|P-value:6.84E-16 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.17|P-value:6.39E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.30|P-value:4.03E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.13|P-value:7.40E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.87|P-value:4.22E-5 ID:SGTC_3315|Compound:9136395|FD-Score:6.24|P-value:1.23E-10 ID:SGTC_3320|Compound:9137005|FD-Score:3.28|P-value:4.23E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.14|P-value:7.14E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.29|P-value:4.43E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:4.16|P-value:1.19E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.55|P-value:1.56E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.98|P-value:2.67E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:4.43|P-value:3.45E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.30|P-value:4.34E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:10.50|P-value:1.35E-26 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.46|P-value:2.40E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.51|P-value:2.27E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.07|P-value:9.16E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:5.12|P-value:9.81E-8 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.80|P-value:6.13E-5 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.78|P-value:6.78E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.64|P-value:1.19E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.90|P-value:3.74E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.67|P-value:9.81E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.54|P-value:1.76E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.29|P-value:4.12E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.54|P-value:1.96E-6 ID:SGTC_1602|Compound:st001878|FD-Score:3.42|P-value:2.58E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.55|P-value:1.64E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.84|P-value:1.50E-9 ID:SGTC_1715|Compound:st032160|FD-Score:3.82|P-value:5.12E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:5.53|P-value:1.02E-8 ID:SGTC_1723|Compound:st034307|FD-Score:-3.58|P-value:1.50E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.55|P-value:1.54E-4 ID:SGTC_1763|Compound:st044482|FD-Score:-3.99|P-value:2.72E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.09|P-value:8.42E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.30|P-value:5.58E-36 ID:SGTC_1903|Compound:st060211|FD-Score:3.23|P-value:5.11E-4 ID:SGTC_2221|Compound:6807166|FD-Score:3.06|P-value:9.30E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.17|P-value:6.36E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.78|P-value:6.11E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.30|P-value:3.96E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.71|P-value:8.08E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.59|P-value:1.34E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.87|P-value:6.84E-16 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.17|P-value:6.39E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.30|P-value:4.03E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.45|P-value:2.24E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.13|P-value:7.40E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.87|P-value:4.22E-5 ID:SGTC_3315|Compound:9136395|FD-Score:6.24|P-value:1.23E-10 ID:SGTC_3320|Compound:9137005|FD-Score:3.28|P-value:4.23E-4

Top fitness defect scores for YFL024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1844 rapamycin 12.30 4.0 nM 5.58E-36 6 4.84E-35 0.18
2 SGTC_773 4358-1457 10.50 44.6 µM 1.35E-26 2 6.59E-26 1.73
3 SGTC_2679 rapamycin 7.87 1.0 nM 6.84E-16 18 1.72E-15 0.42
4 SGTC_3315 9136395 6.24 68.5 µM 1.23E-10 2 2.24E-10 0.45
5 SGTC_1712 st032288 5.84 53.4 µM 1.50E-9 calcium & mitochondrial duress 12 2.55E-9 0.04
6 SGTC_1718 roemerine 5.53 11.9 µM 1.02E-8 redox potentiating 10 1.64E-8 0.95
7 SGTC_1089 terbinafine 5.12 2.2 µM 9.81E-8 3 1.49E-7 0.55
8 SGTC_1597 7-benzyloxygramine 4.54 47.5 µM 1.96E-6 calcium & mitochondrial duress 46 2.75E-6 0.08
9 SGTC_918 glabranin 4.51 770.7 nM 2.27E-6 2 3.17E-6 0.29
10 SGTC_551 k048-0028 4.43 34.9 µM 3.45E-6 4 4.76E-6 0.15
11 SGTC_156 3474-0145 4.16 5.6 µM 1.19E-5 endomembrane recycling 3 1.59E-5 0.09
12 SGTC_312 4092-0653 3.98 6.8 µM 2.67E-5 ergosterol depletion effects on membrane 32 3.48E-5 0.29
13 SGTC_1299 1079-1439 3.90 3.7 µM 3.74E-5 TSC3-RPN4 3 4.83E-5 0.17
14 SGTC_3308 9128332 3.87 17.6 µM 4.22E-5 plasma membrane duress 10 5.44E-5 0.05
15 SGTC_1715 st032160 3.82 10.2 µM 5.12E-5 6 6.56E-5 0.08
16 SGTC_2335 9018011 3.78 154.2 µM 6.11E-5 11 7.79E-5 4.18E-4
17 SGTC_2483 5729050 3.71 27.2 µM 8.08E-5 13 1.02E-4 0.02
18 SGTC_1451 4152-0210 3.67 104.0 µM 9.81E-5 5 1.23E-4 0.20
19 SGTC_2570 licareol 3.59 100.0 µM 1.34E-4 7 1.67E-4 0.31
20 SGTC_1751 st044839 3.55 27.2 µM 1.54E-4 Golgi 6 1.91E-4 0.30

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.371 3.72E-109 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.350 1.42E-96 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.343 1.69E-92 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.336 8.58E-89 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.271 3.06E-57 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.269 1.47E-56 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.257 2.30E-51 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.247 1.18E-47 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.243 3.09E-46 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.242 9.06E-46 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.242 2.04E-45 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.224 3.91E-39 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.221 3.95E-38 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.213 2.29E-35 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.212 3.52E-35 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD