YFL025C / BST1

GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL025C / BST1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:7.31|P-value:2.46E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.46|P-value:2.09E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.65|P-value:1.15E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.54|P-value:1.62E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.53|P-value:9.23E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:8.53|P-value:3.80E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:5.96|P-value:1.03E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:5.15|P-value:2.12E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.88|P-value:5.33E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:5.79|P-value:2.02E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:7.10|P-value:6.89E-9 ID:SGTC_252|Compound:miconazole|FD-Score:7.20|P-value:4.14E-9 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.37|P-value:2.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.79|P-value:7.13E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.39|P-value:2.58E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.85|P-value:1.57E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:8.02|P-value:6.38E-11 ID:SGTC_391|Compound:gliotoxin|FD-Score:11.90|P-value:4.75E-22 ID:SGTC_439|Compound:amiodarone|FD-Score:4.08|P-value:6.33E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.37|P-value:2.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.26|P-value:1.76E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.53|P-value:9.35E-8 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.34|P-value:2.08E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:13.50|P-value:5.17E-28 ID:SGTC_554|Compound:4483-2211|FD-Score:4.78|P-value:7.55E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.56|P-value:1.54E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.53|P-value:5.38E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:-4.32|P-value:1.47E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.16|P-value:5.04E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.84|P-value:1.66E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:6.87|P-value:2.00E-8 ID:SGTC_819|Compound:1013-0258|FD-Score:6.98|P-value:1.19E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:-5.01|P-value:1.44E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:6.85|P-value:2.13E-8 ID:SGTC_847|Compound:0342-0274|FD-Score:5.06|P-value:2.95E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.56|P-value:1.54E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:4.90|P-value:5.00E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.31|P-value:3.26E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.68|P-value:1.04E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.99|P-value:8.32E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.85|P-value:2.17E-8 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.19|P-value:4.61E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.24|P-value:1.58E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.18|P-value:4.75E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.57|P-value:1.47E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.98|P-value:4.18E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.79|P-value:7.20E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.82|P-value:6.66E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:14.60|P-value:3.14E-32 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.49|P-value:1.92E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.87|P-value:1.45E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.41|P-value:2.46E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.00|P-value:3.14E-34 ID:SGTC_1745|Compound:st081495|FD-Score:7.27|P-value:2.92E-9 ID:SGTC_1775|Compound:st081588|FD-Score:-5.76|P-value:8.35E-7 ID:SGTC_1810|Compound:st050138|FD-Score:4.54|P-value:1.64E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.33|P-value:2.16E-7 ID:SGTC_1885|Compound:st057546|FD-Score:4.68|P-value:1.04E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.93|P-value:4.08E-7 ID:SGTC_1949|Compound:st076024|FD-Score:-7.13|P-value:1.72E-9 ID:SGTC_1950|Compound:st077106|FD-Score:3.95|P-value:9.24E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.97|P-value:8.72E-4 ID:SGTC_2077|Compound:5212015|FD-Score:9.78|P-value:1.91E-15 ID:SGTC_2119|Compound:5528445|FD-Score:5.33|P-value:1.12E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.17|P-value:2.03E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.95|P-value:9.11E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.16|P-value:5.10E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.93|P-value:1.49E-8 ID:SGTC_2290|Compound:7904846|FD-Score:5.80|P-value:1.90E-6 ID:SGTC_2322|Compound:7413319|FD-Score:7.12|P-value:6.15E-9 ID:SGTC_2339|Compound:9000433|FD-Score:5.51|P-value:5.83E-6 ID:SGTC_2391|Compound:6285546|FD-Score:4.21|P-value:4.38E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.97|P-value:8.84E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.87|P-value:5.62E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.92|P-value:9.90E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.79|P-value:7.21E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:15.60|P-value:9.73E-37 ID:SGTC_2620|Compound:irigenin|FD-Score:11.50|P-value:9.64E-21 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.19|P-value:1.89E-5 ID:SGTC_2873|Compound:9040596|FD-Score:4.60|P-value:1.36E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.89|P-value:5.29E-5 ID:SGTC_2983|Compound:9022671|FD-Score:5.04|P-value:3.17E-5 ID:SGTC_3020|Compound:9089140|FD-Score:4.98|P-value:3.90E-5 ID:SGTC_3056|Compound:9094900|FD-Score:4.16|P-value:5.11E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.37|P-value:2.71E-4 ID:SGTC_3321|Compound:9137793|FD-Score:5.43|P-value:7.95E-6 ID:SGTC_3322|Compound:9139058|FD-Score:6.24|P-value:3.16E-7 ID:SGTC_3331|Compound:9141060|FD-Score:3.94|P-value:9.44E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:7.31|P-value:2.46E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.46|P-value:2.09E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.65|P-value:1.15E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.54|P-value:1.62E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:6.53|P-value:9.23E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:8.53|P-value:3.80E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:5.96|P-value:1.03E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:5.15|P-value:2.12E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.88|P-value:5.33E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:5.79|P-value:2.02E-6 ID:SGTC_227|Compound:fluconazole|FD-Score:7.10|P-value:6.89E-9 ID:SGTC_252|Compound:miconazole|FD-Score:7.20|P-value:4.14E-9 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.37|P-value:2.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.79|P-value:7.13E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.39|P-value:2.58E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:5.85|P-value:1.57E-6 ID:SGTC_377|Compound:3970-0964|FD-Score:8.02|P-value:6.38E-11 ID:SGTC_391|Compound:gliotoxin|FD-Score:11.90|P-value:4.75E-22 ID:SGTC_439|Compound:amiodarone|FD-Score:4.08|P-value:6.33E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.37|P-value:2.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.26|P-value:1.76E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:6.53|P-value:9.35E-8 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.34|P-value:2.08E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:13.50|P-value:5.17E-28 ID:SGTC_554|Compound:4483-2211|FD-Score:4.78|P-value:7.55E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.56|P-value:1.54E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:5.53|P-value:5.38E-6 ID:SGTC_629|Compound:3448-6466|FD-Score:-4.32|P-value:1.47E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.16|P-value:5.04E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:5.84|P-value:1.66E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:6.87|P-value:2.00E-8 ID:SGTC_819|Compound:1013-0258|FD-Score:6.98|P-value:1.19E-8 ID:SGTC_829|Compound:1635-0120|FD-Score:-5.01|P-value:1.44E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:6.85|P-value:2.13E-8 ID:SGTC_847|Compound:0342-0274|FD-Score:5.06|P-value:2.95E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.56|P-value:1.54E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:4.90|P-value:5.00E-5 ID:SGTC_928|Compound:2764-0428|FD-Score:4.31|P-value:3.26E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.68|P-value:1.04E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:3.99|P-value:8.32E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.85|P-value:2.17E-8 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.19|P-value:4.61E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.24|P-value:1.58E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.18|P-value:4.75E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.57|P-value:1.47E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.98|P-value:4.18E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.79|P-value:7.20E-5 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.82|P-value:6.66E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:14.60|P-value:3.14E-32 ID:SGTC_1545|Compound:lovastatin|FD-Score:4.49|P-value:1.92E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.87|P-value:1.45E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.41|P-value:2.46E-4 ID:SGTC_1687|Compound:st020778|FD-Score:15.00|P-value:3.14E-34 ID:SGTC_1745|Compound:st081495|FD-Score:7.27|P-value:2.92E-9 ID:SGTC_1775|Compound:st081588|FD-Score:-5.76|P-value:8.35E-7 ID:SGTC_1810|Compound:st050138|FD-Score:4.54|P-value:1.64E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.33|P-value:2.16E-7 ID:SGTC_1885|Compound:st057546|FD-Score:4.68|P-value:1.04E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-5.93|P-value:4.08E-7 ID:SGTC_1949|Compound:st076024|FD-Score:-7.13|P-value:1.72E-9 ID:SGTC_1950|Compound:st077106|FD-Score:3.95|P-value:9.24E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.97|P-value:8.72E-4 ID:SGTC_2077|Compound:5212015|FD-Score:9.78|P-value:1.91E-15 ID:SGTC_2119|Compound:5528445|FD-Score:5.33|P-value:1.12E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.17|P-value:2.03E-5 ID:SGTC_2161|Compound:5662504|FD-Score:3.95|P-value:9.11E-4 ID:SGTC_2192|Compound:5915882|FD-Score:4.16|P-value:5.10E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.93|P-value:1.49E-8 ID:SGTC_2290|Compound:7904846|FD-Score:5.80|P-value:1.90E-6 ID:SGTC_2322|Compound:7413319|FD-Score:7.12|P-value:6.15E-9 ID:SGTC_2339|Compound:9000433|FD-Score:5.51|P-value:5.83E-6 ID:SGTC_2391|Compound:6285546|FD-Score:4.21|P-value:4.38E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.97|P-value:8.84E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.87|P-value:5.62E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.92|P-value:9.90E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.79|P-value:7.21E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:15.60|P-value:9.73E-37 ID:SGTC_2620|Compound:irigenin|FD-Score:11.50|P-value:9.64E-21 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.19|P-value:1.89E-5 ID:SGTC_2873|Compound:9040596|FD-Score:4.60|P-value:1.36E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.89|P-value:5.29E-5 ID:SGTC_2983|Compound:9022671|FD-Score:5.04|P-value:3.17E-5 ID:SGTC_3020|Compound:9089140|FD-Score:4.98|P-value:3.90E-5 ID:SGTC_3056|Compound:9094900|FD-Score:4.16|P-value:5.11E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.37|P-value:2.71E-4 ID:SGTC_3321|Compound:9137793|FD-Score:5.43|P-value:7.95E-6 ID:SGTC_3322|Compound:9139058|FD-Score:6.24|P-value:3.16E-7 ID:SGTC_3331|Compound:9141060|FD-Score:3.94|P-value:9.44E-4

Top fitness defect scores for YFL025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2619 obliquin 15.60 87.9 µM 9.73E-37 cell wall 9 3.20E-55
2 SGTC_1687 st020778 15.00 55.4 µM 3.14E-34 20 2.06E-51
3 SGTC_1495 4469-0029 14.60 237.0 µM 3.14E-32 7 2.23E-48
4 SGTC_528 3492-0019 13.50 172.0 µM 5.17E-28 calcium & mitochondrial duress 21 5.62E-42
5 SGTC_391 gliotoxin 11.90 8.3 µM 4.75E-22 6 6.37E-33
6 SGTC_2620 irigenin 11.50 100.0 µM 9.64E-21 4 6.17E-31
7 SGTC_2077 5212015 9.78 200.0 µM 1.91E-15 7 6.91E-23
8 SGTC_150 3970-0969 8.53 77.2 µM 3.80E-12 5 7.13E-18
9 SGTC_377 3970-0964 8.02 33.1 µM 6.38E-11 3 5.19E-16
10 SGTC_43 0570-0105 7.31 72.5 µM 2.46E-9 ERG2 21 1.34E-13
11 SGTC_1745 st081495 7.27 74.0 µM 2.92E-9 RNA processing & uracil transport 17 1.74E-13
12 SGTC_252 miconazole 7.20 1.3 nM 4.14E-9 ergosterol depletion effects on membrane 11 2.96E-13
13 SGTC_2322 7413319 7.12 38.2 µM 6.15E-9 ERAD & cell cycle 46 5.39E-13
14 SGTC_227 fluconazole 7.10 33.5 µM 6.89E-9 azole & statin 31 6.41E-13
15 SGTC_819 1013-0258 6.98 27.7 µM 1.19E-8 16 1.46E-12
16 SGTC_2200 6600604 6.93 21.9 µM 1.49E-8 tubulin folding & SWR complex 20 2.08E-12
17 SGTC_748 0136-0228 6.87 77.9 µM 2.00E-8 redox potentiating 30 3.23E-12
18 SGTC_841 0251-0215 6.85 91.2 µM 2.13E-8 30 3.57E-12
19 SGTC_1053 3366-3204 6.85 134.0 µM 2.17E-8 cell wall 4 3.66E-12
20 SGTC_146 3448-8650 6.53 53.1 µM 9.23E-8 NEO1-PIK1 45 3.31E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.355 9.64E-100 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.335 2.61E-88 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.289 2.17E-65 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.283 2.36E-62 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.265 6.13E-55 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.243 3.58E-46 YML001W YPT7 hom Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
0.236 1.69E-43 YLR374C_d YLR374C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
0.236 1.89E-43 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.231 1.24E-41 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.219 1.21E-37 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.219 1.46E-37 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.219 1.67E-37 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.218 2.01E-37 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.215 3.21E-36 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.214 5.02E-36 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif