YFL032W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL032W / YFL032W

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:17.30|P-value:3.76E-60 ID:SGTC_22|Compound:0964-0034|FD-Score:15.20|P-value:9.36E-47 ID:SGTC_36|Compound:0335-0881|FD-Score:4.83|P-value:2.72E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.20|P-value:3.90E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:12.10|P-value:1.93E-30 ID:SGTC_87|Compound:0100-0052|FD-Score:3.60|P-value:3.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:9.29|P-value:1.08E-18 ID:SGTC_112|Compound:phenothiazine|FD-Score:6.04|P-value:6.34E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:16.70|P-value:4.16E-56 ID:SGTC_142|Compound:0335-0849|FD-Score:9.81|P-value:1.33E-20 ID:SGTC_143|Compound:4032-1194|FD-Score:8.36|P-value:1.74E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:11.30|P-value:6.16E-27 ID:SGTC_200|Compound:k038-0079|FD-Score:4.25|P-value:3.20E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.73|P-value:2.24E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:19.70|P-value:9.57E-77 ID:SGTC_353|Compound:1988-1175|FD-Score:11.60|P-value:4.59E-28 ID:SGTC_367|Compound:0335-0881|FD-Score:4.17|P-value:4.39E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.42|P-value:6.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:17.60|P-value:3.80E-62 ID:SGTC_531|Compound:3788-1495|FD-Score:20.60|P-value:9.37E-84 ID:SGTC_678|Compound:1218-2179|FD-Score:4.16|P-value:4.43E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:6.35|P-value:1.10E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:5.08|P-value:8.82E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.37|P-value:7.51E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.47|P-value:5.45E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.52|P-value:4.61E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.37|P-value:1.96E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.31|P-value:2.51E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.65|P-value:2.91E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.66|P-value:2.88E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.29|P-value:9.66E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:52.30|P-value:0 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.28|P-value:2.84E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.49|P-value:5.01E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.73|P-value:2.23E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.31|P-value:9.07E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.93|P-value:1.09E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.56|P-value:4.06E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-4.32|P-value:2.33E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.68|P-value:1.58E-10 ID:SGTC_1807|Compound:st050092|FD-Score:3.63|P-value:3.14E-4 ID:SGTC_1817|Compound:st052116|FD-Score:5.06|P-value:9.33E-7 ID:SGTC_1822|Compound:st052468|FD-Score:6.21|P-value:2.45E-9 ID:SGTC_1936|Compound:st074407|FD-Score:3.66|P-value:2.84E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-4.60|P-value:7.52E-6 ID:SGTC_2105|Compound:5350118|FD-Score:4.13|P-value:5.05E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.77|P-value:1.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.20|P-value:5.28E-22 ID:SGTC_2673|Compound:kobusone|FD-Score:3.30|P-value:9.40E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.43|P-value:1.52E-5 ID:SGTC_2997|Compound:9067075|FD-Score:11.60|P-value:3.42E-28 ID:SGTC_3002|Compound:9075603|FD-Score:3.37|P-value:7.47E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-5.38|P-value:2.01E-7 ID:SGTC_3013|Compound:9080133|FD-Score:-7.04|P-value:1.68E-11 ID:SGTC_3016|Compound:9080866|FD-Score:3.59|P-value:3.61E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.68|P-value:2.61E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.70|P-value:1.42E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.11|P-value:7.60E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.37|P-value:2.11E-7 ID:SGTC_3078|Compound:9116413|FD-Score:5.95|P-value:1.05E-8 ID:SGTC_3298|Compound:9116858|FD-Score:3.49|P-value:5.17E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:17.30|P-value:3.76E-60 ID:SGTC_22|Compound:0964-0034|FD-Score:15.20|P-value:9.36E-47 ID:SGTC_36|Compound:0335-0881|FD-Score:4.83|P-value:2.72E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:4.20|P-value:3.90E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:12.10|P-value:1.93E-30 ID:SGTC_87|Compound:0100-0052|FD-Score:3.60|P-value:3.55E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:9.29|P-value:1.08E-18 ID:SGTC_112|Compound:phenothiazine|FD-Score:6.04|P-value:6.34E-9 ID:SGTC_137|Compound:0438-0332|FD-Score:16.70|P-value:4.16E-56 ID:SGTC_142|Compound:0335-0849|FD-Score:9.81|P-value:1.33E-20 ID:SGTC_143|Compound:4032-1194|FD-Score:8.36|P-value:1.74E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:11.30|P-value:6.16E-27 ID:SGTC_200|Compound:k038-0079|FD-Score:4.25|P-value:3.20E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:3.73|P-value:2.24E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:19.70|P-value:9.57E-77 ID:SGTC_353|Compound:1988-1175|FD-Score:11.60|P-value:4.59E-28 ID:SGTC_367|Compound:0335-0881|FD-Score:4.17|P-value:4.39E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.42|P-value:6.33E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:17.60|P-value:3.80E-62 ID:SGTC_531|Compound:3788-1495|FD-Score:20.60|P-value:9.37E-84 ID:SGTC_678|Compound:1218-2179|FD-Score:4.16|P-value:4.43E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:6.35|P-value:1.10E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:5.08|P-value:8.82E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.37|P-value:7.51E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.47|P-value:5.45E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.52|P-value:4.61E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-4.37|P-value:1.96E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.31|P-value:2.51E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.65|P-value:2.91E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.66|P-value:2.88E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.29|P-value:9.66E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:52.30|P-value:0 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.28|P-value:2.84E-5 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.49|P-value:5.01E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.73|P-value:2.23E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.31|P-value:9.07E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.93|P-value:1.09E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.56|P-value:4.06E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-4.32|P-value:2.33E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:6.68|P-value:1.58E-10 ID:SGTC_1807|Compound:st050092|FD-Score:3.63|P-value:3.14E-4 ID:SGTC_1817|Compound:st052116|FD-Score:5.06|P-value:9.33E-7 ID:SGTC_1822|Compound:st052468|FD-Score:6.21|P-value:2.45E-9 ID:SGTC_1936|Compound:st074407|FD-Score:3.66|P-value:2.84E-4 ID:SGTC_1980|Compound:st071811|FD-Score:-4.60|P-value:7.52E-6 ID:SGTC_2105|Compound:5350118|FD-Score:4.13|P-value:5.05E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.77|P-value:1.95E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.20|P-value:5.28E-22 ID:SGTC_2673|Compound:kobusone|FD-Score:3.30|P-value:9.40E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.43|P-value:1.52E-5 ID:SGTC_2997|Compound:9067075|FD-Score:11.60|P-value:3.42E-28 ID:SGTC_3002|Compound:9075603|FD-Score:3.37|P-value:7.47E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-5.38|P-value:2.01E-7 ID:SGTC_3013|Compound:9080133|FD-Score:-7.04|P-value:1.68E-11 ID:SGTC_3016|Compound:9080866|FD-Score:3.59|P-value:3.61E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.68|P-value:2.61E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.70|P-value:1.42E-10 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.11|P-value:7.60E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.37|P-value:2.11E-7 ID:SGTC_3078|Compound:9116413|FD-Score:5.95|P-value:1.05E-8 ID:SGTC_3298|Compound:9116858|FD-Score:3.49|P-value:5.17E-4

Top fitness defect scores for YFL032W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1239 0337-0584 52.30 35.4 µM 0 unfolded protein response 1 0
2 SGTC_531 3788-1495 20.60 174.0 µM 9.37E-84 unfolded protein response 2 3.29E-94
3 SGTC_255 tunicamycin 19.70 200.5 nM 9.57E-77 unfolded protein response 4 2.65E-86
4 SGTC_513 4245-1575 17.60 41.7 µM 3.80E-62 unfolded protein response 2 7.71E-70
5 SGTC_16 erodoxin 17.30 22.8 µM 3.76E-60 unfolded protein response 5 1.37E-67
6 SGTC_137 0438-0332 16.70 85.4 µM 4.16E-56 ubiquinone biosynthesis & proteasome 10 4.98E-63
7 SGTC_22 0964-0034 15.20 14.5 µM 9.36E-47 unfolded protein response 4 1.75E-52
8 SGTC_86 0417-1630 12.10 471.9 µM 1.93E-30 ubiquinone biosynthesis & proteasome 28 4.32E-34
9 SGTC_2997 9067075 11.60 71.4 µM 3.42E-28 unfolded protein response 5 1.49E-31
10 SGTC_353 1988-1175 11.60 58.3 µM 4.59E-28 unfolded protein response 4 2.07E-31
11 SGTC_158 k038-0087 11.30 26.4 µM 6.16E-27 ubiquinone biosynthesis & proteasome 28 3.86E-30
12 SGTC_2651 1327-0036 10.20 5.0 µM 5.28E-22 25 1.40E-24
13 SGTC_142 0335-0849 9.81 62.7 µM 1.33E-20 ubiquinone biosynthesis & proteasome 31 5.31E-23
14 SGTC_108 0509-0257 9.29 621.1 µM 1.08E-18 3 7.52E-21
15 SGTC_143 4032-1194 8.36 15.7 µM 1.74E-15 7 3.09E-17
16 SGTC_3059 1327-0034 6.70 3.0 µM 1.42E-10 26 1.05E-11
17 SGTC_1789 tunicamycin 6.68 25.0 nM 1.58E-10 unfolded protein response 13 1.18E-11
18 SGTC_794 k038-0031 6.35 316.0 µM 1.10E-9 ubiquinone biosynthesis & proteasome 49 1.05E-10
19 SGTC_1822 st052468 6.21 42.0 µM 2.45E-9 1 2.57E-10
20 SGTC_112 phenothiazine 6.04 287.2 µM 6.34E-9 unfolded protein response 4 7.51E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.765 0 YHR079C IRE1 hom Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.731 0 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.614 0 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.357 1.12E-101 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.308 1.70E-74 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.276 8.14E-60 YMR161W HLJ1 hom Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
0.269 7.64E-57 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.269 1.20E-56 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.265 4.24E-55 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.264 1.15E-54 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.249 1.96E-48 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.248 4.81E-48 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.244 1.63E-46 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.235 1.60E-43 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.231 5.10E-42 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress