YFL034C-A / RPL22B

Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL034C-A / RPL22B

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.79|P-value:1.05E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.23|P-value:6.83E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.85|P-value:8.20E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:5.59|P-value:2.12E-8 ID:SGTC_939|Compound:1165-0479|FD-Score:-4.52|P-value:3.92E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.64|P-value:1.57E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.67|P-value:2.37E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.55|P-value:2.15E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.54|P-value:4.33E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.43|P-value:4.02E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.22|P-value:7.01E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:8.00|P-value:2.11E-15 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.18|P-value:9.48E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.74|P-value:1.06E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.11|P-value:2.85E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.26|P-value:7.29E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.17|P-value:9.90E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.86|P-value:7.92E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.22|P-value:1.77E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.13|P-value:9.34E-10 ID:SGTC_2011|Compound:4012611|FD-Score:-3.28|P-value:5.79E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.63|P-value:1.94E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.23|P-value:7.85E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.56|P-value:2.50E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.48|P-value:5.70E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-5.16|P-value:1.72E-7 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.02|P-value:3.46E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.65|P-value:2.16E-6 ID:SGTC_2537|Compound:larixol|FD-Score:5.11|P-value:2.78E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.81|P-value:9.79E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.05|P-value:3.62E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.62|P-value:2.01E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.46|P-value:3.58E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.46|P-value:3.60E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.82|P-value:1.19E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.00|P-value:4.48E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.23|P-value:7.86E-4 ID:SGTC_3134|Compound:9127454|FD-Score:7.34|P-value:2.91E-13 ID:SGTC_3159|Compound:9100096|FD-Score:3.45|P-value:3.67E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.28|P-value:6.67E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.79|P-value:1.05E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.23|P-value:6.83E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.85|P-value:8.20E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:5.59|P-value:2.12E-8 ID:SGTC_939|Compound:1165-0479|FD-Score:-4.52|P-value:3.92E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.64|P-value:1.57E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:4.67|P-value:2.37E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.55|P-value:2.15E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.54|P-value:4.33E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.43|P-value:4.02E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.22|P-value:7.01E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:8.00|P-value:2.11E-15 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.18|P-value:9.48E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.74|P-value:1.06E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.11|P-value:2.85E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.26|P-value:7.29E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.17|P-value:9.90E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.86|P-value:7.92E-5 ID:SGTC_1949|Compound:st076024|FD-Score:4.22|P-value:1.77E-5 ID:SGTC_2006|Compound:4011487|FD-Score:6.13|P-value:9.34E-10 ID:SGTC_2011|Compound:4012611|FD-Score:-3.28|P-value:5.79E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.63|P-value:1.94E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.23|P-value:7.85E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.56|P-value:2.50E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.48|P-value:5.70E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-5.16|P-value:1.72E-7 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.02|P-value:3.46E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.65|P-value:2.16E-6 ID:SGTC_2537|Compound:larixol|FD-Score:5.11|P-value:2.78E-7 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.81|P-value:9.79E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.05|P-value:3.62E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.62|P-value:2.01E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.46|P-value:3.58E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.46|P-value:3.60E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:4.82|P-value:1.19E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.00|P-value:4.48E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.23|P-value:7.86E-4 ID:SGTC_3134|Compound:9127454|FD-Score:7.34|P-value:2.91E-13 ID:SGTC_3159|Compound:9100096|FD-Score:3.45|P-value:3.67E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.28|P-value:6.67E-4

Top fitness defect scores for YFL034C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1285 0929-0069 8.00 65.5 µM 2.11E-15 1 6.40E-16
2 SGTC_3134 9127454 7.34 49.5 µM 2.91E-13 1 1.04E-13
3 SGTC_2006 4011487 6.13 200.0 µM 9.34E-10 endomembrane recycling 43 4.45E-10
4 SGTC_936 3005-4620 5.59 401.0 µM 2.12E-8 4 1.13E-8
5 SGTC_2537 larixol 5.11 68.9 µM 2.78E-7 9 1.62E-7
6 SGTC_2668 2',4'-dihydroxychalcone 4.82 15.1 µM 1.19E-6 6 7.29E-7
7 SGTC_1074 carmofur 4.67 3.8 µM 2.37E-6 exosome 9 1.49E-6
8 SGTC_1214 0358-0031 4.54 63.7 µM 4.33E-6 6 2.79E-6
9 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.48 3.7 µM 5.70E-6 52 3.70E-6
10 SGTC_1949 st076024 4.22 69.1 µM 1.77E-5 15 1.20E-5
11 SGTC_1585 2',4'-dihydroxychalcone 4.11 10.4 µM 2.85E-5 28 1.96E-5
12 SGTC_2592 piperlongumine 4.05 83.3 µM 3.62E-5 TSC3-RPN4 35 2.51E-5
13 SGTC_2758 dehydroepiandrosterone 4.00 69.3 µM 4.48E-5 36 3.14E-5
14 SGTC_1942 st076330 3.86 65.2 µM 7.92E-5 31 5.66E-5
15 SGTC_623 k072-0108 3.85 16.9 µM 8.20E-5 heme biosynthesis & mitochondrial translocase 24 5.86E-5
16 SGTC_2541 muurolladie-3-one 3.81 83.1 µM 9.79E-5 excess fatty acid 35 7.05E-5
17 SGTC_52 0329-0193 3.79 875.0 nM 1.05E-4 TSC3-RPN4 40 7.58E-5
18 SGTC_1289 0976-0073 3.75 69.1 µM 1.23E-4 17 8.94E-5
19 SGTC_1601 4'-hydroxyflavanone 3.74 55.5 µM 1.27E-4 RPP1 & pyrimidine depletion 35 9.25E-5
20 SGTC_2529 gangaleoidin 3.71 93.6 µM 1.42E-4 22 1.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.55E-14 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.109 2.48E-10 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.104 1.35E-9 YLL010C PSR1 hom Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.099 9.46E-9 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.098 1.42E-8 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.096 2.26E-8 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.094 5.23E-8 YGL192W IME4 hom Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
0.093 6.74E-8 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
0.090 1.74E-7 YCL030C HIS4 hom Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
0.089 2.74E-7 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.087 5.12E-7 YGL037C PNC1 hom Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
0.085 9.28E-7 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.084 9.90E-7 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.079 5.13E-6 YLR187W SKG3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication
0.078 6.62E-6 YBR176W ECM31 hom Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate