YFL034C-B / MOB2

Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL034C-B / MOB2

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-3.39|P-value:4.92E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.23|P-value:1.74E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.02|P-value:4.19E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.13|P-value:2.68E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.16|P-value:1.35E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-2.80|P-value:6.08E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.94|P-value:3.07E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.09|P-value:3.13E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.02|P-value:2.53E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.47|P-value:6.12E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.66|P-value:2.50E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.30|P-value:1.29E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.38|P-value:5.13E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.99|P-value:4.70E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.02|P-value:4.18E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:2.83|P-value:8.81E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:2.94|P-value:5.89E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-2.74|P-value:7.81E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-2.97|P-value:3.10E-4 ID:SGTC_1644|Compound:st010134|FD-Score:-2.72|P-value:8.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.20|P-value:1.96E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.04|P-value:3.84E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.24|P-value:1.65E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.59|P-value:3.48E-5 ID:SGTC_2226|Compound:7298446|FD-Score:-3.08|P-value:1.93E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.81|P-value:9.61E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.65|P-value:2.54E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.26|P-value:1.55E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-2.92|P-value:3.78E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.25|P-value:1.14E-6 ID:SGTC_2369|Compound:9071472|FD-Score:-3.19|P-value:1.21E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.56|P-value:2.18E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.78|P-value:7.06E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.20|P-value:1.96E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.33|P-value:1.13E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.80|P-value:9.92E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.92|P-value:3.40E-6 ID:SGTC_2715|Compound:st079500|FD-Score:3.69|P-value:2.08E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.89|P-value:7.04E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.29|P-value:4.36E-7 ID:SGTC_2923|Compound:7992654|FD-Score:-3.52|P-value:2.66E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.54|P-value:2.33E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.30|P-value:1.26E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-2.73|P-value:7.95E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-2.69|P-value:9.48E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-3.39|P-value:4.92E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.23|P-value:1.74E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.02|P-value:4.19E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.13|P-value:2.68E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-3.16|P-value:1.35E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-2.80|P-value:6.08E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.94|P-value:3.07E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:3.09|P-value:3.13E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.02|P-value:2.53E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.47|P-value:6.12E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.66|P-value:2.50E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.30|P-value:1.29E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:-3.38|P-value:5.13E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:2.99|P-value:4.70E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.02|P-value:4.18E-4 ID:SGTC_1550|Compound:gossypolone|FD-Score:2.83|P-value:8.81E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:2.94|P-value:5.89E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-2.74|P-value:7.81E-4 ID:SGTC_1634|Compound:st006576|FD-Score:-2.97|P-value:3.10E-4 ID:SGTC_1644|Compound:st010134|FD-Score:-2.72|P-value:8.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.20|P-value:1.96E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.04|P-value:3.84E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.24|P-value:1.65E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.59|P-value:3.48E-5 ID:SGTC_2226|Compound:7298446|FD-Score:-3.08|P-value:1.93E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.81|P-value:9.61E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.65|P-value:2.54E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.26|P-value:1.55E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-2.92|P-value:3.78E-4 ID:SGTC_2349|Compound:9023730|FD-Score:4.25|P-value:1.14E-6 ID:SGTC_2369|Compound:9071472|FD-Score:-3.19|P-value:1.21E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.56|P-value:2.18E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.78|P-value:7.06E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.20|P-value:1.96E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.33|P-value:1.13E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:2.80|P-value:9.92E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.92|P-value:3.40E-6 ID:SGTC_2715|Compound:st079500|FD-Score:3.69|P-value:2.08E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.89|P-value:7.04E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.29|P-value:4.36E-7 ID:SGTC_2923|Compound:7992654|FD-Score:-3.52|P-value:2.66E-5 ID:SGTC_2924|Compound:9010168|FD-Score:-3.54|P-value:2.33E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.30|P-value:1.26E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-2.73|P-value:7.95E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-2.69|P-value:9.48E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.11|P-value:2.95E-4

Top fitness defect scores for YFL034C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2349 9023730 4.25 187.1 µM 1.14E-6 2 1.07E-5 0.36
2 SGTC_2715 st079500 3.69 56.4 µM 2.08E-5 5 1.11E-4 0.45
3 SGTC_1015 4130-4525 3.66 82.0 µM 2.50E-5 60S ribosome export 10 1.29E-4 0.08
4 SGTC_2301 7769476 3.65 200.0 µM 2.54E-5 16 1.30E-4 0.09
5 SGTC_2123 5259487 3.59 200.0 µM 3.48E-5 3 1.68E-4 0.01
6 SGTC_991 3996-0057 3.47 64.7 µM 6.12E-5 6 2.65E-4 0.14
7 SGTC_2571 chrysanthemic acid 3.33 100.0 µM 1.13E-4 8 4.33E-4 0.01
8 SGTC_2963 9082507 3.30 9.0 µM 1.26E-4 15 4.76E-4 0.06
9 SGTC_1093 fluphenazine 3.30 8.0 µM 1.29E-4 10 4.84E-4 0.00
10 SGTC_2344 7990960 3.26 77.0 µM 1.55E-4 54 5.61E-4 0.11
11 SGTC_2116 5511452 3.24 16.9 µM 1.65E-4 8 5.91E-4 0.02
12 SGTC_44 0929-0055 3.23 61.2 µM 1.74E-4 17 6.17E-4 0.17
13 SGTC_1648 st011736 3.20 69.8 µM 1.96E-4 PDR1 7 6.78E-4 0.13
14 SGTC_2409 alverine citrate 3.20 64.0 µM 1.96E-4 22 6.80E-4 0.12
15 SGTC_129 0088-0017 3.13 176.6 µM 2.68E-4 11 8.76E-4 0.07
16 SGTC_3302 9125395 3.11 16.4 µM 2.95E-4 13 9.46E-4 0.02
17 SGTC_524 r073-0010 3.09 27.8 µM 3.13E-4 28 9.92E-4 0.09
18 SGTC_1670 st016595 3.04 4.0 µM 3.84E-4 6 0.00117 0.06
19 SGTC_1486 3970-0793 3.02 4.5 µM 4.18E-4 14 0.00126 0.02
20 SGTC_128 0906-2981 3.02 13.4 µM 4.19E-4 22 0.00126 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.231 7.40E-42 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.198 6.06E-31 YJL115W ASF1 hom Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
0.151 1.93E-18 YFL045C SEC53 het Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
0.144 5.68E-17 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.141 2.08E-16 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.122 1.39E-12 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.102 3.57E-9 YBL013W FMT1 hom Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
0.102 4.27E-9 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication
0.100 7.31E-9 YOR372C NDD1 het Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
0.099 9.98E-9 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.091 1.15E-7 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.090 1.59E-7 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.090 2.01E-7 YGR014W MSB2 hom Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
0.086 5.54E-7 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.086 5.56E-7 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C