YFL038C / YPT1

Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL038C / YPT1

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:4.89|P-value:4.70E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:7.40|P-value:8.89E-12 ID:SGTC_81|Compound:0411-0046|FD-Score:14.30|P-value:5.98E-39 ID:SGTC_91|Compound:0417-1751|FD-Score:8.15|P-value:6.33E-14 ID:SGTC_110|Compound:0850-0284|FD-Score:6.45|P-value:2.37E-9 ID:SGTC_126|Compound:0417-1624|FD-Score:3.77|P-value:3.15E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.55|P-value:1.83E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.05|P-value:1.22E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.43|P-value:9.52E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.15|P-value:8.48E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.44|P-value:2.82E-5 ID:SGTC_389|Compound:tpck|FD-Score:14.90|P-value:4.32E-42 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.48|P-value:8.19E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.40|P-value:2.78E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.93|P-value:1.83E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:5.20|P-value:1.22E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:11.40|P-value:1.89E-25 ID:SGTC_994|Compound:3910-0338|FD-Score:3.78|P-value:3.10E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.48|P-value:8.06E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:11.70|P-value:1.11E-26 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.08|P-value:2.03E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:6.33|P-value:4.42E-9 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.17|P-value:7.85E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.72|P-value:9.27E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:9.29|P-value:1.54E-17 ID:SGTC_1717|Compound:st033143|FD-Score:-3.79|P-value:2.54E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.22|P-value:6.56E-5 ID:SGTC_1772|Compound:st048439|FD-Score:3.57|P-value:6.11E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.69|P-value:3.58E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.59|P-value:1.58E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.68|P-value:4.30E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-4.88|P-value:3.98E-6 ID:SGTC_2269|Compound:7935389|FD-Score:-3.50|P-value:6.71E-4 ID:SGTC_2344|Compound:7990960|FD-Score:12.60|P-value:1.36E-30 ID:SGTC_2346|Compound:9031566|FD-Score:-4.24|P-value:5.06E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.72|P-value:3.27E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.70|P-value:1.16E-7 ID:SGTC_2413|Compound:inermin|FD-Score:56.30|P-value:0 ID:SGTC_2414|Compound:st077232|FD-Score:-4.62|P-value:1.15E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.66|P-value:4.55E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.84|P-value:2.50E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.68|P-value:6.51E-10 ID:SGTC_2756|Compound:carbadox|FD-Score:4.21|P-value:6.69E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:6.11|P-value:1.43E-8 ID:SGTC_2819|Compound:7996655|FD-Score:-7.26|P-value:1.60E-11 ID:SGTC_2820|Compound:7989630|FD-Score:-5.59|P-value:1.56E-7 ID:SGTC_2852|Compound:9023854|FD-Score:3.42|P-value:9.83E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.90|P-value:2.06E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.96|P-value:1.69E-4 ID:SGTC_2980|Compound:9014342|FD-Score:6.42|P-value:2.73E-9 ID:SGTC_2987|Compound:9018338|FD-Score:4.35|P-value:4.05E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.72|P-value:3.81E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-3.88|P-value:1.85E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.64|P-value:4.87E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.62|P-value:5.26E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.75|P-value:2.90E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.14|P-value:1.58E-6 ID:SGTC_3219|Compound:9131112|FD-Score:3.46|P-value:8.61E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.40|P-value:8.97E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.89|P-value:4.70E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:7.40|P-value:8.89E-12 ID:SGTC_81|Compound:0411-0046|FD-Score:14.30|P-value:5.98E-39 ID:SGTC_91|Compound:0417-1751|FD-Score:8.15|P-value:6.33E-14 ID:SGTC_110|Compound:0850-0284|FD-Score:6.45|P-value:2.37E-9 ID:SGTC_126|Compound:0417-1624|FD-Score:3.77|P-value:3.15E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.55|P-value:1.83E-5 ID:SGTC_177|Compound:1327-0068|FD-Score:4.05|P-value:1.22E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.43|P-value:9.52E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.15|P-value:8.48E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:4.44|P-value:2.82E-5 ID:SGTC_389|Compound:tpck|FD-Score:14.90|P-value:4.32E-42 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.48|P-value:8.19E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.40|P-value:2.78E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:3.93|P-value:1.83E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:5.20|P-value:1.22E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:11.40|P-value:1.89E-25 ID:SGTC_994|Compound:3910-0338|FD-Score:3.78|P-value:3.10E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.48|P-value:8.06E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:11.70|P-value:1.11E-26 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.08|P-value:2.03E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:6.33|P-value:4.42E-9 ID:SGTC_1306|Compound:1185-0270|FD-Score:4.17|P-value:7.85E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.72|P-value:9.27E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:9.29|P-value:1.54E-17 ID:SGTC_1717|Compound:st033143|FD-Score:-3.79|P-value:2.54E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.22|P-value:6.56E-5 ID:SGTC_1772|Compound:st048439|FD-Score:3.57|P-value:6.11E-4 ID:SGTC_1773|Compound:st048542|FD-Score:-3.69|P-value:3.58E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.59|P-value:1.58E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.68|P-value:4.30E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-4.88|P-value:3.98E-6 ID:SGTC_2269|Compound:7935389|FD-Score:-3.50|P-value:6.71E-4 ID:SGTC_2344|Compound:7990960|FD-Score:12.60|P-value:1.36E-30 ID:SGTC_2346|Compound:9031566|FD-Score:-4.24|P-value:5.06E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-3.72|P-value:3.27E-4 ID:SGTC_2351|Compound:9026858|FD-Score:5.70|P-value:1.16E-7 ID:SGTC_2413|Compound:inermin|FD-Score:56.30|P-value:0 ID:SGTC_2414|Compound:st077232|FD-Score:-4.62|P-value:1.15E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.66|P-value:4.55E-4 ID:SGTC_2478|Compound:5763493|FD-Score:3.84|P-value:2.50E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.68|P-value:6.51E-10 ID:SGTC_2756|Compound:carbadox|FD-Score:4.21|P-value:6.69E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:6.11|P-value:1.43E-8 ID:SGTC_2819|Compound:7996655|FD-Score:-7.26|P-value:1.60E-11 ID:SGTC_2820|Compound:7989630|FD-Score:-5.59|P-value:1.56E-7 ID:SGTC_2852|Compound:9023854|FD-Score:3.42|P-value:9.83E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.90|P-value:2.06E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.96|P-value:1.69E-4 ID:SGTC_2980|Compound:9014342|FD-Score:6.42|P-value:2.73E-9 ID:SGTC_2987|Compound:9018338|FD-Score:4.35|P-value:4.05E-5 ID:SGTC_3054|Compound:9094397|FD-Score:3.72|P-value:3.81E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-3.88|P-value:1.85E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.64|P-value:4.87E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.62|P-value:5.26E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.75|P-value:2.90E-4 ID:SGTC_3181|Compound:9108277|FD-Score:5.14|P-value:1.58E-6 ID:SGTC_3219|Compound:9131112|FD-Score:3.46|P-value:8.61E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.40|P-value:8.97E-4

Top fitness defect scores for YFL038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2413 inermin 56.30 26.1 µM 0 1 0 32.60
2 SGTC_389 tpck 14.90 16.7 µM 4.32E-42 1 2.04E-50 4.48
3 SGTC_81 0411-0046 14.30 10.0 µM 5.98E-39 4 1.25E-46 2.84
4 SGTC_2344 7990960 12.60 77.0 µM 1.36E-30 4 1.46E-36 1.10
5 SGTC_1060 3448-7350 11.70 82.0 µM 1.11E-26 Golgi 1 7.54E-32 2.98
6 SGTC_878 0828-0289 11.40 13.7 µM 1.89E-25 3 2.29E-30 0.63
7 SGTC_1679 4130-1276 9.29 6.7 µM 1.54E-17 Golgi 8 7.78E-21 0.29
8 SGTC_91 0417-1751 8.15 58.4 µM 6.33E-14 Golgi 2 1.75E-16 0.91
9 SGTC_71 0417-1750 7.40 47.8 µM 8.89E-12 Golgi 3 6.75E-14 0.71
10 SGTC_2679 rapamycin 6.68 1.0 nM 6.51E-10 22 1.19E-11 0.08
11 SGTC_110 0850-0284 6.45 111.6 µM 2.37E-9 1 5.62E-11 1.76
12 SGTC_2980 9014342 6.42 25.3 µM 2.73E-9 7 6.67E-11 0.78
13 SGTC_1301 naphtanilide LB 6.33 4.8 µM 4.42E-9 heme requiring 3 1.19E-10 0.94
14 SGTC_2776 terbinafine 6.11 19.9 µM 1.43E-8 cell wall signaling 2 4.89E-10 0.32
15 SGTC_2351 9026858 5.70 72.3 µM 1.16E-7 RNA processing & uracil transport 2 6.04E-9 0.65
16 SGTC_834 0312-0008 5.20 75.7 µM 1.22E-6 NEO1 7 1.02E-7 0.29
17 SGTC_3181 9108277 5.14 49.5 µM 1.58E-6 iron homeostasis 6 1.40E-7 0.06
18 SGTC_1267 0828-0272 5.08 9.5 µM 2.03E-6 4 1.88E-7 1.14
19 SGTC_56 0957-0365 4.89 83.2 µM 4.70E-6 Golgi 5 5.17E-7 0.88
20 SGTC_1327 1436-0082 4.72 2.2 µM 9.27E-6 4 1.17E-6 0.36

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.553 8.42E-269 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.349 1.69E-96 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.335 1.32E-88 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.308 1.69E-74 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.304 6.76E-73 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.273 3.43E-58 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.241 1.00E-45 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.226 4.16E-40 YPL082C MOT1 het Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA
0.212 2.44E-35 YBR254C TRS20 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
0.204 5.04E-33 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.201 7.47E-32 YEL055C POL5 het DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
0.197 7.68E-31 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
0.189 3.32E-28 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.182 2.72E-26 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.178 3.26E-25 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation