HIPHOP chemogenomics database
YFL039C / ACT1 
Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YFL039C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.293 | 2.90E-67 | YML085C | TUB1 | het | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication |
| 0.182 | 2.49E-26 | YML097C | VPS9 | hom | A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin |
| 0.164 | 9.64E-22 | YLR020C | YEH2 | hom | Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism |
| 0.151 | 1.44E-18 | YGR078C | PAC10 | hom | Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding |
| 0.150 | 2.44E-18 | YJL129C | TRK1 | hom | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication |
| 0.141 | 1.98E-16 | YHR187W | IKI1 | hom | Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin |
| 0.140 | 4.24E-16 | YMR314W | PRE5 | het | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
| 0.138 | 1.12E-15 | YKL019W | RAM2 | het | Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor |
| 0.138 | 1.26E-15 | YHR012W | VPS29 | hom | Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval |
| 0.136 | 3.07E-15 | YOR362C | PRE10 | het | Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
| 0.135 | 4.46E-15 | YGR253C | PUP2 | het | Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
| 0.135 | 5.13E-15 | YNL147W | LSM7 | hom | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress |
| 0.134 | 5.72E-15 | YKL058W | TOA2 | het | TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress |
| 0.133 | 9.42E-15 | YHR108W | GGA2 | hom | Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin |
| 0.133 | 1.05E-14 | YOL040C | RPS15 | het | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |