YFL039C / ACT1

Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL039C / ACT1

Click on Significant Values for Screen Details ID:SGTC_176|Compound:1486-1328|FD-Score:5.24|P-value:3.00E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:7.78|P-value:1.38E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.12|P-value:1.32E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:5.53|P-value:1.43E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.86|P-value:3.82E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-5.48|P-value:7.80E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-10.00|P-value:4.22E-12 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.76|P-value:1.72E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-6.24|P-value:8.76E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.80|P-value:8.61E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.39|P-value:5.52E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.45|P-value:1.09E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.88|P-value:7.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.92|P-value:3.31E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-7.28|P-value:2.91E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:5.39|P-value:2.08E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.94|P-value:6.26E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-7.06|P-value:6.22E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:5.96|P-value:4.56E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:-7.60|P-value:9.62E-8 ID:SGTC_917|Compound:harmaline|FD-Score:-9.86|P-value:8.59E-12 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.91|P-value:3.40E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:8.43|P-value:1.20E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:7.68|P-value:1.98E-7 ID:SGTC_1503|Compound:4585-0012|FD-Score:6.69|P-value:5.26E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.05|P-value:2.38E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:5.01|P-value:5.33E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.87|P-value:3.68E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.07|P-value:4.58E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:15.50|P-value:2.46E-25 ID:SGTC_1752|Compound:st044819|FD-Score:-5.30|P-value:1.24E-4 ID:SGTC_1754|Compound:st042065|FD-Score:11.60|P-value:8.13E-15 ID:SGTC_1760|Compound:st045453|FD-Score:6.77|P-value:4.04E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.37|P-value:2.20E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.91|P-value:2.64E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:-5.53|P-value:6.82E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:6.10|P-value:3.01E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-4.82|P-value:4.20E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.83|P-value:6.53E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.54|P-value:8.19E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.12|P-value:2.01E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-4.71|P-value:5.49E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-4.86|P-value:3.83E-4 ID:SGTC_2164|Compound:5685496|FD-Score:6.31|P-value:1.65E-5 ID:SGTC_2266|Compound:7929956|FD-Score:5.37|P-value:2.20E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.85|P-value:7.63E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.71|P-value:5.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.12|P-value:3.97E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.96|P-value:1.99E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-6.08|P-value:1.43E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.82|P-value:3.55E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.78|P-value:8.91E-4 ID:SGTC_2854|Compound:9024559|FD-Score:8.59|P-value:6.50E-9 ID:SGTC_2873|Compound:9040596|FD-Score:6.27|P-value:1.85E-5 ID:SGTC_2910|Compound:7948405|FD-Score:-4.89|P-value:3.56E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.77|P-value:4.74E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-5.69|P-value:4.37E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-4.56|P-value:7.84E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.79|P-value:7.15E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-4.47|P-value:9.46E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.86|P-value:7.56E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.97|P-value:2.90E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.81|P-value:8.38E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.41|P-value:1.97E-4 ID:SGTC_3284|Compound:9108171|FD-Score:5.66|P-value:1.03E-4 ID:SGTC_3288|Compound:9119690|FD-Score:5.64|P-value:1.08E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.23|P-value:9.24E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:5.24|P-value:3.00E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:7.78|P-value:1.38E-7 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:7.12|P-value:1.32E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:5.53|P-value:1.43E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.86|P-value:3.82E-4 ID:SGTC_397|Compound:arbidol|FD-Score:-5.48|P-value:7.80E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-10.00|P-value:4.22E-12 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.76|P-value:1.72E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-6.24|P-value:8.76E-6 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.80|P-value:8.61E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-6.39|P-value:5.52E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:6.45|P-value:1.09E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.88|P-value:7.21E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.92|P-value:3.31E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-7.28|P-value:2.91E-7 ID:SGTC_737|Compound:1950-0117|FD-Score:5.39|P-value:2.08E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.94|P-value:6.26E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-7.06|P-value:6.22E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:5.96|P-value:4.56E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:-7.60|P-value:9.62E-8 ID:SGTC_917|Compound:harmaline|FD-Score:-9.86|P-value:8.59E-12 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.91|P-value:3.40E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:8.43|P-value:1.20E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:7.68|P-value:1.98E-7 ID:SGTC_1503|Compound:4585-0012|FD-Score:6.69|P-value:5.26E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.05|P-value:2.38E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:5.01|P-value:5.33E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-4.87|P-value:3.68E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.07|P-value:4.58E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:15.50|P-value:2.46E-25 ID:SGTC_1752|Compound:st044819|FD-Score:-5.30|P-value:1.24E-4 ID:SGTC_1754|Compound:st042065|FD-Score:11.60|P-value:8.13E-15 ID:SGTC_1760|Compound:st045453|FD-Score:6.77|P-value:4.04E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.37|P-value:2.20E-4 ID:SGTC_1803|Compound:st050068|FD-Score:6.91|P-value:2.64E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:-5.53|P-value:6.82E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:6.10|P-value:3.01E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-4.82|P-value:4.20E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.83|P-value:6.53E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.54|P-value:8.19E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.12|P-value:2.01E-4 ID:SGTC_2077|Compound:5212015|FD-Score:-4.71|P-value:5.49E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-4.86|P-value:3.83E-4 ID:SGTC_2164|Compound:5685496|FD-Score:6.31|P-value:1.65E-5 ID:SGTC_2266|Compound:7929956|FD-Score:5.37|P-value:2.20E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.85|P-value:7.63E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-4.71|P-value:5.44E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.12|P-value:3.97E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:-5.96|P-value:1.99E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:-6.08|P-value:1.43E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.82|P-value:3.55E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.78|P-value:8.91E-4 ID:SGTC_2854|Compound:9024559|FD-Score:8.59|P-value:6.50E-9 ID:SGTC_2873|Compound:9040596|FD-Score:6.27|P-value:1.85E-5 ID:SGTC_2910|Compound:7948405|FD-Score:-4.89|P-value:3.56E-4 ID:SGTC_2913|Compound:7966556|FD-Score:-4.77|P-value:4.74E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-5.69|P-value:4.37E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-4.56|P-value:7.84E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.79|P-value:7.15E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-4.47|P-value:9.46E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.86|P-value:7.56E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-4.97|P-value:2.90E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.81|P-value:8.38E-4 ID:SGTC_3278|Compound:9139605|FD-Score:5.41|P-value:1.97E-4 ID:SGTC_3284|Compound:9108171|FD-Score:5.66|P-value:1.03E-4 ID:SGTC_3288|Compound:9119690|FD-Score:5.64|P-value:1.08E-4 ID:SGTC_3304|Compound:9125678|FD-Score:7.23|P-value:9.24E-7

Top fitness defect scores for YFL039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1597 7-benzyloxygramine 15.50 47.5 µM 2.46E-25 calcium & mitochondrial duress 6 1.75E-54 0.07
2 SGTC_1754 st042065 11.60 16.1 µM 8.13E-15 NEO1-PIK1 4 3.66E-31 1.52
3 SGTC_2854 9024559 8.59 71.4 µM 6.50E-9 2 4.28E-18 2.51
4 SGTC_1067 clotrimazole 8.43 1.4 µM 1.20E-8 azole & statin 4 1.67E-17 0.27
5 SGTC_2582 agaric acid 8.12 100.0 µM 3.97E-8 redox potentiating 9 2.33E-16 0.20
6 SGTC_227 fluconazole 7.78 33.5 µM 1.38E-7 azole & statin 22 3.65E-15 4.11E-4
7 SGTC_1084 voriconazole 7.68 435.0 nM 1.98E-7 azole & statin 3 8.13E-15 1.56
8 SGTC_3304 9125678 7.23 46.1 µM 9.24E-7 16 2.42E-13 0.16
9 SGTC_241 5hr heat shock (37°C) + cantharidin 7.12 155.4 µM 1.32E-6 cell wall signaling 5 5.28E-13 1.00
10 SGTC_1803 st050068 6.91 52.4 µM 2.64E-6 NEO1-PIK1 6 2.45E-12 0.03
11 SGTC_2679 rapamycin 6.82 1.0 nM 3.55E-6 20 4.69E-12 0.02
12 SGTC_1760 st045453 6.77 10.4 µM 4.04E-6 NEO1-PIK1 3 6.26E-12 3.14
13 SGTC_1503 4585-0012 6.69 61.3 µM 5.26E-6 2 1.11E-11 1.64
14 SGTC_467 ro 31-8220 6.45 72.8 µM 1.09E-5 calcium & mitochondrial duress 5 5.54E-11 0.08
15 SGTC_2164 5685496 6.31 200.0 µM 1.65E-5 4 1.38E-10 1.39
16 SGTC_2873 9040596 6.27 71.4 µM 1.85E-5 1 1.76E-10 1.35
17 SGTC_1880 MG-132 6.10 525.0 µM 3.01E-5 9 5.16E-10 0.47
18 SGTC_910 3454-3003 5.96 490.0 µM 4.56E-5 1 1.29E-9 1.15
19 SGTC_1912 st060209 5.83 90.8 µM 6.53E-5 3 2.83E-9 0.58
20 SGTC_3142 9086498 5.79 49.5 µM 7.15E-5 iron homeostasis 25 3.45E-9 0.18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.293 2.90E-67 YML085C TUB1 het Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication
0.182 2.49E-26 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.164 9.64E-22 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.151 1.44E-18 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.150 2.44E-18 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.141 1.98E-16 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.140 4.24E-16 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.138 1.12E-15 YKL019W RAM2 het Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.138 1.26E-15 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.136 3.07E-15 YOR362C PRE10 het Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.135 4.46E-15 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.135 5.13E-15 YNL147W LSM7 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.134 5.72E-15 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.133 9.42E-15 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.133 1.05E-14 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19