HIPHOP chemogenomics database

YFL041W / FET5

Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport

Zygosity: Homozygous strain

fixedexpanded
Profile for YFL041W / FET5

Click on Significant Values for Screen Details

Top fitness defect scores for YFL041W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2917	7979103	5.26	53.8 µM	2.00E-9		8	7.09E-8
2	SGTC_2030	5175110	4.29	200.0 µM	8.12E-7	Golgi	21	8.99E-6
3	SGTC_2941	9056145	4.15	11.2 µM	1.78E-6		14	1.69E-5
4	SGTC_2040	5100729	3.78	123.0 µM	1.17E-5		45	7.77E-5
5	SGTC_1779	st039427	3.69	55.0 µM	1.87E-5		33	1.13E-4
6	SGTC_2034	5197015	3.64	53.1 µM	2.35E-5	SWF1 & branched chain AA biosynthesis	31	1.37E-4
7	SGTC_379	3970-0972	3.48	5.9 µM	5.02E-5	tubulin folding & SWR complex	52	2.52E-4
8	SGTC_1725	st036284	3.41	20.6 µM	6.93E-5		53	3.27E-4
9	SGTC_669	0108-0021	3.34	26.2 µM	9.33E-5	fatty acid desaturase (OLE1)	123	4.17E-4
10	SGTC_1756	st041558	3.27	35.5 µM	1.30E-4		24	5.46E-4
11	SGTC_2962	9082311	2.98	13.2 µM	4.39E-4		67	0.00146
12	SGTC_1211	1056-0033	2.97	32.3 µM	4.47E-4		35	0.00149
13	SGTC_1740	st038286	2.96	13.2 µM	4.63E-4		78	0.00153
14	SGTC_2046	4110841	2.95	106.0 µM	4.83E-4	iron homeostasis	67	0.00158
15	SGTC_434	1-hexadecyl-2-methylglycero-3 PC	2.94	8.0 µM	4.98E-4		73	0.00162
16	SGTC_1008	4106-0037	2.93	6.0 µM	5.36E-4	PDR1	52	0.00172
17	SGTC_3201	9113999	2.87	49.5 µM	6.67E-4		88	0.00206
18	SGTC_757	1066-0008	2.81	322.0 µM	8.43E-4	Golgi	75	0.00249
19	SGTC_2013	4024628	2.74	200.0 µM	0.00111		123	0.00311
20	SGTC_2048	5246248	2.71	200.0 µM	0.00121		47	0.00333

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.257	1.14E-51	YBL086C_p	YBL086C_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.240	2.64E-45	YKL202W_d	YKL202W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213	1.01E-35	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.195	5.75E-30	YNR028W	CPR8	hom	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.187	8.96E-28	YMR096W	SNZ1	hom	Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.178	2.31E-25	YBR083W	TEC1	hom	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.178	2.43E-25	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.177	6.09E-25	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.176	7.73E-25	YDR382W	RPP2B	hom	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.176	1.00E-24	YDR505C	PSP1	hom	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.176	9.78E-25	YDR122W	KIN1	hom	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.172	8.15E-24	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.172	8.47E-24	YOR082C_d	YOR082C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.170	3.68E-23	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.167	1.79E-22	YNL042W	BOP3	hom	Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury