YFL041W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL041W-A / YFL041W-A

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:-3.68|P-value:1.53E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.58|P-value:2.94E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.47|P-value:2.90E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.42|P-value:3.52E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.88|P-value:6.05E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:5.10|P-value:2.31E-7 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.71|P-value:1.18E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.66|P-value:2.00E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.34|P-value:1.01E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.66|P-value:1.47E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.91|P-value:4.32E-12 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.96|P-value:4.35E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.01|P-value:4.12E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.17|P-value:8.35E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.23|P-value:6.89E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.21|P-value:7.25E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.62|P-value:1.86E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.52|P-value:2.72E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.62|P-value:2.38E-6 ID:SGTC_1731|Compound:st035964|FD-Score:3.44|P-value:3.33E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-5.34|P-value:7.75E-8 ID:SGTC_1825|Compound:st052143|FD-Score:5.45|P-value:3.61E-8 ID:SGTC_1884|Compound:5633444|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_1896|Compound:st058441|FD-Score:4.48|P-value:4.71E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.22|P-value:7.20E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.37|P-value:8.73E-6 ID:SGTC_2259|Compound:7964009|FD-Score:3.12|P-value:9.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.39|P-value:8.11E-6 ID:SGTC_2484|Compound:5809818|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.22|P-value:1.21E-7 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.44|P-value:3.23E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.55|P-value:2.16E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.27|P-value:6.02E-4 ID:SGTC_2903|Compound:5923464|FD-Score:5.56|P-value:1.91E-8 ID:SGTC_3006|Compound:9075424|FD-Score:3.18|P-value:8.19E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.41|P-value:6.39E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.34|P-value:4.66E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.98|P-value:4.89E-7 ID:SGTC_3264|Compound:9137442|FD-Score:-3.29|P-value:6.14E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.27|P-value:6.72E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.68|P-value:1.53E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.58|P-value:2.94E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.47|P-value:2.90E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.42|P-value:3.52E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.88|P-value:6.05E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:5.10|P-value:2.31E-7 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.71|P-value:1.18E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.66|P-value:2.00E-6 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.34|P-value:4.70E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.34|P-value:1.01E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.66|P-value:1.47E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.91|P-value:4.32E-12 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.96|P-value:4.35E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.01|P-value:4.12E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.17|P-value:8.35E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.23|P-value:6.89E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.21|P-value:7.25E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.62|P-value:1.71E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.62|P-value:1.86E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.52|P-value:2.72E-4 ID:SGTC_1694|Compound:st024011|FD-Score:4.62|P-value:2.38E-6 ID:SGTC_1731|Compound:st035964|FD-Score:3.44|P-value:3.33E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-5.34|P-value:7.75E-8 ID:SGTC_1825|Compound:st052143|FD-Score:5.45|P-value:3.61E-8 ID:SGTC_1884|Compound:5633444|FD-Score:4.15|P-value:2.02E-5 ID:SGTC_1896|Compound:st058441|FD-Score:4.48|P-value:4.71E-6 ID:SGTC_1930|Compound:st074634|FD-Score:3.22|P-value:7.20E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.48|P-value:2.80E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.37|P-value:8.73E-6 ID:SGTC_2259|Compound:7964009|FD-Score:3.12|P-value:9.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-4.39|P-value:8.11E-6 ID:SGTC_2484|Compound:5809818|FD-Score:3.48|P-value:2.89E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.22|P-value:1.21E-7 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.44|P-value:3.23E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:3.55|P-value:2.16E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.27|P-value:6.02E-4 ID:SGTC_2903|Compound:5923464|FD-Score:5.56|P-value:1.91E-8 ID:SGTC_3006|Compound:9075424|FD-Score:3.18|P-value:8.19E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.41|P-value:6.39E-6 ID:SGTC_3136|Compound:9095672|FD-Score:3.34|P-value:4.66E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-4.98|P-value:4.89E-7 ID:SGTC_3264|Compound:9137442|FD-Score:-3.29|P-value:6.14E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.27|P-value:6.72E-4

Top fitness defect scores for YFL041W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1126 isoteolin 6.91 1.0 µM 4.32E-12 3 2.44E-12
2 SGTC_2903 5923464 5.56 63.9 µM 1.91E-8 1 1.34E-8
3 SGTC_1825 st052143 5.45 62.6 µM 3.61E-8 5 2.57E-8
4 SGTC_2615 purpurogallin-4-carboxylic acid 5.22 100.0 µM 1.21E-7 redox potentiating 38 8.88E-8
5 SGTC_948 3448-0295 5.10 75.3 µM 2.31E-7 11 1.72E-7
6 SGTC_1051 3253-3903 4.66 78.0 µM 2.00E-6 8 1.57E-6
7 SGTC_1694 st024011 4.62 44.9 µM 2.38E-6 ERG2 21 1.88E-6
8 SGTC_134 0269-0018 4.58 6.9 µM 2.94E-6 110 2.33E-6
9 SGTC_1896 st058441 4.48 89.0 µM 4.71E-6 6 3.77E-6
10 SGTC_3016 9080866 4.41 49.5 µM 6.39E-6 19 5.16E-6
11 SGTC_1884 5633444 4.15 25.0 µM 2.02E-5 redox potentiating 44 1.68E-5
12 SGTC_1175 0741-0056 3.96 27.6 µM 4.35E-5 15 3.67E-5
13 SGTC_782 0083-0095 3.88 30.5 µM 6.05E-5 27 5.16E-5
14 SGTC_1045 1348-1485 3.71 165.0 µM 1.18E-4 41 1.02E-4
15 SGTC_1109 tnp00067 3.66 928.3 nM 1.47E-4 20 1.27E-4
16 SGTC_869 0564-0080 3.64 44.1 µM 1.54E-4 30 1.34E-4
17 SGTC_1392 3455-1037 3.62 33.9 µM 1.71E-4 25 1.49E-4
18 SGTC_2726 cimetidine 3.55 79.3 µM 2.16E-4 9 1.90E-4
19 SGTC_2243 6634756 3.48 200.0 µM 2.80E-4 31 2.47E-4
20 SGTC_2484 5809818 3.48 12.0 µM 2.89E-4 25 2.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.09E-11 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.099 9.47E-9 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.095 3.83E-8 YCL051W LRE1 hom Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication
0.094 4.39E-8 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.094 4.59E-8 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.093 6.11E-8 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.091 1.32E-7 YLR432W IMD3 hom Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
0.084 1.21E-6 YGR240C PFK1 hom Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
0.082 1.79E-6 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.079 4.31E-6 YML051W GAL80 hom Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
0.078 6.47E-6 YJL003W COX16 hom Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase
0.078 6.65E-6 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.075 1.27E-5 YPL095C EEB1 hom Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
0.075 1.50E-5 YPR016C TIF6 het Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
0.074 1.74E-5 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase