YFL042C_p

Putative protein of unknown function; YFL042C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL042C / YFL042C

Click on Significant Values for Screen Details ID:SGTC_132|Compound:0417-1715|FD-Score:3.54|P-value:2.60E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.03|P-value:3.99E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.01|P-value:4.21E-5 ID:SGTC_499|Compound:genistein|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.24|P-value:7.41E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.26|P-value:7.04E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:5.01|P-value:4.59E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.36|P-value:4.72E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.86|P-value:7.38E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.35|P-value:4.95E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.96|P-value:5.24E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.22|P-value:7.66E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:4.38|P-value:8.75E-6 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.47|P-value:5.92E-6 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.26|P-value:6.80E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.86|P-value:7.80E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.33|P-value:5.48E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.39|P-value:4.20E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.38|P-value:4.48E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.87|P-value:7.19E-5 ID:SGTC_2394|Compound:5221648|FD-Score:5.08|P-value:3.11E-7 ID:SGTC_2404|Compound:5161160|FD-Score:4.23|P-value:1.73E-5 ID:SGTC_2414|Compound:st077232|FD-Score:4.57|P-value:3.75E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.03|P-value:3.94E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.86|P-value:7.74E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.51|P-value:2.95E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.31|P-value:5.68E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.25|P-value:7.27E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.00|P-value:4.67E-7 ID:SGTC_2850|Compound:9015429|FD-Score:3.53|P-value:2.76E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.16|P-value:9.25E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.27|P-value:6.47E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.60|P-value:3.23E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-4.42|P-value:7.07E-6 ID:SGTC_3220|Compound:9131269|FD-Score:5.62|P-value:1.75E-8 ID:SGTC_3221|Compound:9128209|FD-Score:5.87|P-value:4.39E-9 ID:SGTC_132|Compound:0417-1715|FD-Score:3.54|P-value:2.60E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.03|P-value:3.99E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.01|P-value:4.21E-5 ID:SGTC_499|Compound:genistein|FD-Score:3.56|P-value:2.47E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.24|P-value:7.41E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.26|P-value:7.04E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:5.01|P-value:4.59E-7 ID:SGTC_797|Compound:k781-0471|FD-Score:-3.36|P-value:4.72E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.86|P-value:7.38E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.35|P-value:4.95E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.96|P-value:5.24E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.22|P-value:7.66E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:4.38|P-value:8.75E-6 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.47|P-value:5.92E-6 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.26|P-value:6.80E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.51|P-value:2.89E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.86|P-value:7.80E-5 ID:SGTC_1906|Compound:st060206|FD-Score:3.33|P-value:5.48E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.39|P-value:4.20E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.38|P-value:4.48E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.87|P-value:7.19E-5 ID:SGTC_2394|Compound:5221648|FD-Score:5.08|P-value:3.11E-7 ID:SGTC_2404|Compound:5161160|FD-Score:4.23|P-value:1.73E-5 ID:SGTC_2414|Compound:st077232|FD-Score:4.57|P-value:3.75E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.03|P-value:3.94E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.86|P-value:7.74E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.51|P-value:2.95E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.31|P-value:5.68E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:3.25|P-value:7.27E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:5.00|P-value:4.67E-7 ID:SGTC_2850|Compound:9015429|FD-Score:3.53|P-value:2.76E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.16|P-value:9.25E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.27|P-value:6.47E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.60|P-value:3.23E-6 ID:SGTC_3219|Compound:9131112|FD-Score:-4.42|P-value:7.07E-6 ID:SGTC_3220|Compound:9131269|FD-Score:5.62|P-value:1.75E-8 ID:SGTC_3221|Compound:9128209|FD-Score:5.87|P-value:4.39E-9

Top fitness defect scores for YFL042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3221 9128209 5.87 49.5 µM 4.39E-9 4 2.22E-9
2 SGTC_3220 9131269 5.62 49.5 µM 1.75E-8 4 9.30E-9
3 SGTC_2394 5221648 5.08 200.0 µM 3.11E-7 10 1.84E-7
4 SGTC_647 0140-0236 5.01 81.0 µM 4.59E-7 4 2.76E-7
5 SGTC_2690 usnic acid 5.00 100.0 µM 4.67E-7 11 2.81E-7
6 SGTC_3217 9129673 4.60 49.5 µM 3.23E-6 18 2.09E-6
7 SGTC_2414 st077232 4.57 92.9 µM 3.75E-6 14 2.44E-6
8 SGTC_1439 4092-1168 4.47 46.0 µM 5.92E-6 5 3.93E-6
9 SGTC_1412 3909-8563 4.38 178.0 µM 8.75E-6 4 5.88E-6
10 SGTC_2404 5161160 4.23 200.0 µM 1.73E-5 13 1.19E-5
11 SGTC_2419 paclitaxel 4.03 166.5 µM 3.94E-5 37 2.80E-5
12 SGTC_260 nsc-65238 4.03 4.0 µM 3.99E-5 endomembrane recycling 15 2.84E-5
13 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 4.01 44.4 nM 4.21E-5 DNA damage response 29 3.00E-5
14 SGTC_1349 flufenamic acid 3.96 69.0 µM 5.24E-5 12 3.77E-5
15 SGTC_2425 5628681 3.86 7.8 µM 7.74E-5 28 5.65E-5
16 SGTC_1889 st059080 3.86 5.2 µM 7.80E-5 19 5.69E-5
17 SGTC_1431 4049-0260 3.79 9.1 µM 1.02E-4 6 7.51E-5
18 SGTC_499 genistein 3.56 192.0 µM 2.47E-4 4 1.88E-4
19 SGTC_132 0417-1715 3.54 25.8 µM 2.60E-4 RPP1 & pyrimidine depletion 32 1.99E-4
20 SGTC_2850 9015429 3.53 58.4 µM 2.76E-4 24 2.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 7.92E-34 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.197 9.94E-31 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.159 2.30E-20 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.151 1.58E-18 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.151 1.82E-18 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.149 4.51E-18 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.145 3.33E-17 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.141 2.34E-16 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.137 1.48E-15 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.132 1.77E-14 YEL072W RMD6 hom Protein required for sporulation
0.132 1.79E-14 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.130 3.44E-14 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.125 4.15E-13 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.123 8.28E-13 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.119 4.81E-12 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family