YFL044C / OTU1

Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL044C / OTU1

Click on Significant Values for Screen Details ID:SGTC_375|Compound:3970-0961|FD-Score:-2.89|P-value:5.94E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.42|P-value:6.00E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.18|P-value:1.84E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-5.48|P-value:3.97E-10 ID:SGTC_775|Compound:4577-0580|FD-Score:2.83|P-value:7.21E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:4.02|P-value:3.06E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:-2.94|P-value:4.84E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.32|P-value:1.00E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.83|P-value:7.46E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.84|P-value:2.67E-11 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.08|P-value:2.28E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.83|P-value:7.35E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.31|P-value:9.73E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.36|P-value:8.25E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.22|P-value:2.31E-9 ID:SGTC_1733|Compound:st037357|FD-Score:-2.81|P-value:8.20E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-2.87|P-value:6.44E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.82|P-value:7.66E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.12|P-value:1.86E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.24|P-value:1.39E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.94|P-value:4.77E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.16|P-value:1.93E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:2.86|P-value:6.39E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.07|P-value:2.80E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.13|P-value:2.14E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.79|P-value:8.66E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.40|P-value:6.78E-5 ID:SGTC_2211|Compound:7117706|FD-Score:2.85|P-value:6.89E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.75|P-value:1.29E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.95|P-value:4.62E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.44|P-value:5.48E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.00|P-value:3.80E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.25|P-value:1.30E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.21|P-value:1.58E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-4.57|P-value:1.46E-7 ID:SGTC_2986|Compound:9022445|FD-Score:3.14|P-value:2.09E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.20|P-value:1.58E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-2.89|P-value:5.94E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.42|P-value:6.00E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.18|P-value:1.84E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:-5.48|P-value:3.97E-10 ID:SGTC_775|Compound:4577-0580|FD-Score:2.83|P-value:7.21E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:4.02|P-value:3.06E-6 ID:SGTC_822|Compound:1487-0950|FD-Score:-2.94|P-value:4.84E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.32|P-value:1.00E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.83|P-value:7.46E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.84|P-value:2.67E-11 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.08|P-value:2.28E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.83|P-value:7.35E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.31|P-value:9.73E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.36|P-value:8.25E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.22|P-value:2.31E-9 ID:SGTC_1733|Compound:st037357|FD-Score:-2.81|P-value:8.20E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-2.87|P-value:6.44E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.82|P-value:7.66E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.12|P-value:1.86E-6 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.24|P-value:1.39E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.94|P-value:4.77E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.16|P-value:1.93E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:2.86|P-value:6.39E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.07|P-value:2.80E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.13|P-value:2.14E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-2.79|P-value:8.66E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.40|P-value:6.78E-5 ID:SGTC_2211|Compound:7117706|FD-Score:2.85|P-value:6.89E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.75|P-value:1.29E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-2.95|P-value:4.62E-4 ID:SGTC_2435|Compound:5706476|FD-Score:3.44|P-value:5.48E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.00|P-value:3.80E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.25|P-value:1.30E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.21|P-value:1.58E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-4.57|P-value:1.46E-7 ID:SGTC_2986|Compound:9022445|FD-Score:3.14|P-value:2.09E-4 ID:SGTC_3108|Compound:9121785|FD-Score:3.20|P-value:1.58E-4

Top fitness defect scores for YFL044C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1251 0490-5699 5.84 265.0 µM 2.67E-11 11 2.61E-9
2 SGTC_1855 st056195 4.12 39.6 µM 1.86E-6 60S ribosome export 13 1.92E-5
3 SGTC_1357 1503-1303 4.08 39.5 µM 2.28E-6 27 2.26E-5
4 SGTC_814 3342-0569 4.02 96.0 µM 3.06E-6 18 2.86E-5
5 SGTC_1907 st060210 3.94 83.7 µM 4.77E-6 21 4.08E-5
6 SGTC_2435 5706476 3.44 10.6 µM 5.48E-5 37 2.89E-4
7 SGTC_535 2293-4129 3.42 48.2 µM 6.00E-5 NEO1 90 3.11E-4
8 SGTC_2164 5685496 3.40 200.0 µM 6.78E-5 34 3.43E-4
9 SGTC_1437 4092-1038 3.31 11.6 µM 9.73E-5 32 4.59E-4
10 SGTC_2821 7996764 3.25 71.4 µM 1.30E-4 70 5.80E-4
11 SGTC_3108 9121785 3.20 49.5 µM 1.58E-4 41 6.76E-4
12 SGTC_1923 st058458 3.16 19.1 µM 1.93E-4 73 7.95E-4
13 SGTC_2986 9022445 3.14 71.4 µM 2.09E-4 41 8.46E-4
14 SGTC_2002 4023503 3.13 131.0 µM 2.14E-4 mitochondrial processes 76 8.65E-4
15 SGTC_1968 st069590 3.07 43.6 µM 2.80E-4 40 0.00107
16 SGTC_1955 wogonin 2.86 32.4 µM 6.39E-4 68 0.00209
17 SGTC_2211 7117706 2.85 200.0 µM 6.89E-4 54 0.00221
18 SGTC_775 4577-0580 2.83 57.3 µM 7.21E-4 45 0.00230
19 SGTC_1432 4049-0298 2.83 68.4 µM 7.35E-4 45 0.00233
20 SGTC_1851 st056236 2.82 18.9 µM 7.66E-4 68 0.00241

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.276 1.21E-59 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.273 1.68E-58 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.260 6.25E-53 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.216 1.15E-36 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.209 3.58E-34 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.205 3.82E-33 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.204 6.42E-33 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.203 1.52E-32 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.202 4.68E-32 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.201 5.21E-32 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.197 1.02E-30 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.197 1.26E-30 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.192 3.88E-29 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.189 2.46E-28 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.186 1.95E-27 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene