YFL049W / SWP82

Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL049W / SWP82

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.38|P-value:1.84E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.09|P-value:5.35E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.66|P-value:5.45E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.00|P-value:1.22E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.03|P-value:7.04E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.08|P-value:5.59E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.54|P-value:7.75E-7 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.20|P-value:3.80E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.53|P-value:8.42E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.88|P-value:2.03E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:3.17|P-value:3.98E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.23|P-value:3.18E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.17|P-value:4.01E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.40|P-value:1.76E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.77|P-value:3.52E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.64|P-value:6.12E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.97|P-value:8.65E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-2.94|P-value:9.87E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.66|P-value:5.50E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:7.05|P-value:4.58E-14 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.18|P-value:3.76E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.81|P-value:1.85E-7 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.33|P-value:8.71E-9 ID:SGTC_1259|Compound:0671-0132|FD-Score:8.69|P-value:2.13E-20 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.37|P-value:1.81E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.63|P-value:6.06E-5 ID:SGTC_1845|Compound:st056753|FD-Score:-3.10|P-value:5.37E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.58|P-value:7.76E-5 ID:SGTC_2020|Compound:4017018|FD-Score:4.11|P-value:6.87E-6 ID:SGTC_2118|Compound:5526350|FD-Score:3.05|P-value:6.25E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.43|P-value:1.49E-6 ID:SGTC_2243|Compound:6634756|FD-Score:4.67|P-value:4.00E-7 ID:SGTC_2264|Compound:7948757|FD-Score:-3.36|P-value:2.00E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.98|P-value:7.91E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.92|P-value:9.84E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.05|P-value:6.51E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.84|P-value:2.65E-5 ID:SGTC_2354|Compound:9060492|FD-Score:-3.17|P-value:4.15E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.25|P-value:2.89E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.27|P-value:2.70E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.37|P-value:1.91E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.15|P-value:4.44E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.47|P-value:1.22E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-2.95|P-value:9.39E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.41|P-value:1.56E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.04|P-value:6.87E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.99|P-value:1.29E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.07|P-value:6.03E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.17|P-value:3.94E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.38|P-value:1.84E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:3.09|P-value:5.35E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.66|P-value:5.45E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.00|P-value:1.22E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.03|P-value:7.04E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.08|P-value:5.59E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.54|P-value:7.75E-7 ID:SGTC_466|Compound:geldanamycin|FD-Score:-3.20|P-value:3.80E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.53|P-value:8.42E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:3.88|P-value:2.03E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:3.17|P-value:3.98E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.23|P-value:3.18E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.17|P-value:4.01E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.40|P-value:1.76E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.77|P-value:3.52E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.64|P-value:6.12E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.97|P-value:8.65E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:-2.94|P-value:9.87E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.66|P-value:5.50E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:7.05|P-value:4.58E-14 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.18|P-value:3.76E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.81|P-value:1.85E-7 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.33|P-value:8.71E-9 ID:SGTC_1259|Compound:0671-0132|FD-Score:8.69|P-value:2.13E-20 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.37|P-value:1.81E-4 ID:SGTC_1748|Compound:st037455|FD-Score:3.63|P-value:6.06E-5 ID:SGTC_1845|Compound:st056753|FD-Score:-3.10|P-value:5.37E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.58|P-value:7.76E-5 ID:SGTC_2020|Compound:4017018|FD-Score:4.11|P-value:6.87E-6 ID:SGTC_2118|Compound:5526350|FD-Score:3.05|P-value:6.25E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.43|P-value:1.49E-6 ID:SGTC_2243|Compound:6634756|FD-Score:4.67|P-value:4.00E-7 ID:SGTC_2264|Compound:7948757|FD-Score:-3.36|P-value:2.00E-4 ID:SGTC_2307|Compound:7538926|FD-Score:2.98|P-value:7.91E-4 ID:SGTC_2338|Compound:7999974|FD-Score:2.92|P-value:9.84E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.05|P-value:6.51E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.84|P-value:2.65E-5 ID:SGTC_2354|Compound:9060492|FD-Score:-3.17|P-value:4.15E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.25|P-value:2.89E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.27|P-value:2.70E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.37|P-value:1.91E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.15|P-value:4.44E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-4.47|P-value:1.22E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.32|P-value:2.26E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-2.95|P-value:9.39E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.41|P-value:1.56E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.04|P-value:6.87E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.99|P-value:1.29E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.07|P-value:6.03E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.17|P-value:3.94E-4

Top fitness defect scores for YFL049W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1259 0671-0132 8.69 43.0 µM 2.13E-20 1 1.84E-18
2 SGTC_1240 0356-0016 7.05 42.1 µM 4.58E-14 mitochondrial response to ROS 6 8.87E-13
3 SGTC_1257 0669-0121 5.33 16.0 µM 8.71E-9 7 4.89E-8
4 SGTC_1245 0418-0076 4.81 17.2 µM 1.85E-7 ERG2 13 7.62E-7
5 SGTC_2243 6634756 4.67 200.0 µM 4.00E-7 8 1.53E-6
6 SGTC_457 grayanotoxin iii 4.54 135.0 µM 7.75E-7 40 2.77E-6
7 SGTC_473 2-arachidonoylglycerol 4.53 10.0 µM 8.42E-7 14 2.98E-6
8 SGTC_8 0354-0001 4.38 70.0 µM 1.84E-6 61 6.01E-6
9 SGTC_2487 5918373 4.37 44.0 µM 1.91E-6 7 6.23E-6
10 SGTC_2020 4017018 4.11 200.0 µM 6.87E-6 16 1.97E-5
11 SGTC_483 fpl-64176 3.88 144.0 µM 2.03E-5 cell wall 13 5.21E-5
12 SGTC_304 1310-0298 3.66 97.0 µM 5.45E-5 cell wall 72 1.27E-4
13 SGTC_1167 k781-0610 3.66 148.0 µM 5.50E-5 RNA processing & uracil transport 37 1.28E-4
14 SGTC_1748 st037455 3.63 53.6 µM 6.06E-5 40 1.40E-4
15 SGTC_2011 4012611 3.58 177.0 µM 7.76E-5 mitochondrial processes 44 1.75E-4
16 SGTC_3018 9082602 3.41 49.5 µM 1.56E-4 64 3.28E-4
17 SGTC_1313 1220-0047 3.37 237.0 µM 1.81E-4 61 3.75E-4
18 SGTC_2688 kanamycin b 3.32 96.7 µM 2.26E-4 calcium & mitochondrial duress 474 4.58E-4
19 SGTC_2477 5967686 3.27 25.2 µM 2.70E-4 52 5.37E-4
20 SGTC_2428 5615643 3.25 7.8 µM 2.89E-4 51 5.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 9.42E-19 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.134 5.52E-15 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.132 1.51E-14 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.117 1.31E-11 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.114 3.61E-11 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.114 4.20E-11 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.113 4.91E-11 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.109 2.44E-10 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.108 3.52E-10 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.107 4.83E-10 YDR109C_p YDR109C_p hom Putative kinase
0.106 6.68E-10 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.105 1.22E-9 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.102 3.05E-9 YOL075C_p YOL075C_p hom Putative ABC transporter
0.100 7.47E-9 YGL102C_d YGL102C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
0.099 7.73E-9 YLR255C_d YLR255C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data