YFL052W_p

Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL052W / YFL052W

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:2.91|P-value:7.39E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.49|P-value:7.28E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:4.05|P-value:5.25E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.13|P-value:4.31E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.20|P-value:2.40E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.08|P-value:5.20E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.31|P-value:2.11E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.14|P-value:3.16E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.01|P-value:6.87E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.96|P-value:8.43E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.33|P-value:1.42E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.66|P-value:2.11E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:3.41|P-value:1.00E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.84|P-value:9.74E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.41|P-value:1.03E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.20|P-value:2.56E-6 ID:SGTC_1614|Compound:st002383|FD-Score:-2.96|P-value:8.07E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.62|P-value:4.07E-5 ID:SGTC_1727|Compound:st034309|FD-Score:5.05|P-value:2.18E-8 ID:SGTC_1732|Compound:st034308|FD-Score:-4.16|P-value:4.42E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-4.59|P-value:4.64E-7 ID:SGTC_1751|Compound:st044839|FD-Score:2.89|P-value:7.99E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.10|P-value:4.82E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.21|P-value:2.37E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-2.94|P-value:8.74E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.17|P-value:3.71E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.20|P-value:3.24E-4 ID:SGTC_2345|Compound:9052315|FD-Score:2.91|P-value:7.45E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.57|P-value:5.13E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.48|P-value:7.64E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.21|P-value:2.34E-4 ID:SGTC_3227|Compound:9130768|FD-Score:-2.94|P-value:8.66E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.91|P-value:7.39E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.49|P-value:7.28E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:4.05|P-value:5.25E-6 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.13|P-value:4.31E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.20|P-value:2.40E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.08|P-value:5.20E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.31|P-value:2.11E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.14|P-value:3.16E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.01|P-value:6.87E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.96|P-value:8.43E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.33|P-value:1.42E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.66|P-value:2.11E-7 ID:SGTC_882|Compound:0843-0131|FD-Score:3.41|P-value:1.00E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.20|P-value:2.45E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.84|P-value:9.74E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.41|P-value:1.03E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.20|P-value:2.56E-6 ID:SGTC_1614|Compound:st002383|FD-Score:-2.96|P-value:8.07E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.62|P-value:4.07E-5 ID:SGTC_1727|Compound:st034309|FD-Score:5.05|P-value:2.18E-8 ID:SGTC_1732|Compound:st034308|FD-Score:-4.16|P-value:4.42E-6 ID:SGTC_1737|Compound:st035557|FD-Score:-4.59|P-value:4.64E-7 ID:SGTC_1751|Compound:st044839|FD-Score:2.89|P-value:7.99E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.10|P-value:4.82E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.21|P-value:2.37E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-2.94|P-value:8.74E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-3.17|P-value:3.71E-4 ID:SGTC_2153|Compound:5569715|FD-Score:-3.20|P-value:3.24E-4 ID:SGTC_2345|Compound:9052315|FD-Score:2.91|P-value:7.45E-4 ID:SGTC_2384|Compound:9036245|FD-Score:3.57|P-value:5.13E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.48|P-value:7.64E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.21|P-value:2.34E-4 ID:SGTC_3227|Compound:9130768|FD-Score:-2.94|P-value:8.66E-4

Top fitness defect scores for YFL052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1727 st034309 5.05 9.9 µM 2.18E-8 15 2.25E-7
2 SGTC_875 0709-0210 4.66 25.7 µM 2.11E-7 fatty acid desaturase (OLE1) 22 1.59E-6
3 SGTC_1379 2144-0755 4.20 36.5 µM 2.56E-6 15 1.36E-5
4 SGTC_404 fumagillin 4.05 50.0 µM 5.25E-6 18 2.52E-5
5 SGTC_865 0488-0499 3.96 301.0 µM 8.43E-6 19 3.79E-5
6 SGTC_1726 st035556 3.62 14.6 µM 4.07E-5 47 1.47E-4
7 SGTC_2384 9036245 3.57 200.0 µM 5.13E-5 42 1.79E-4
8 SGTC_300 r073-0011 3.49 5.0 µM 7.28E-5 37 2.42E-4
9 SGTC_2625 euphol 3.48 100.0 µM 7.64E-5 45 2.52E-4
10 SGTC_882 0843-0131 3.41 351.0 µM 1.00E-4 27 3.19E-4
11 SGTC_1371 2421-0008 3.41 32.7 µM 1.03E-4 mitochondrial processes 65 3.25E-4
12 SGTC_873 0591-4978 3.33 488.0 µM 1.42E-4 31 4.31E-4
13 SGTC_2751 anetholtrithion 3.21 17.2 µM 2.34E-4 56 6.62E-4
14 SGTC_1886 st057356 3.21 49.9 µM 2.37E-4 60S ribosome export 42 6.68E-4
15 SGTC_488 nitrendipine 3.20 139.0 µM 2.40E-4 78 6.76E-4
16 SGTC_910 3454-3003 3.20 490.0 µM 2.45E-4 49 6.89E-4
17 SGTC_699 0375-0592 3.14 111.0 µM 3.16E-4 iron homeostasis 54 8.58E-4
18 SGTC_152 4469-0003 2.91 551.2 µM 7.39E-4 60 0.00178
19 SGTC_2345 9052315 2.91 157.4 µM 7.45E-4 70 0.00180
20 SGTC_1751 st044839 2.89 27.2 µM 7.99E-4 Golgi 35 0.00191

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 4.06E-34 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.196 2.68E-30 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.194 7.27E-30 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.145 2.68E-17 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.123 6.91E-13 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.122 1.43E-12 YOR306C MCH5 hom Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
0.117 1.26E-11 YOR302W YOR302W hom CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA
0.110 1.44E-10 YNL324W_d YNL324W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 1.70E-10 YOL069W NUF2 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.105 1.24E-9 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.101 5.32E-9 YPL152W-A_p YPL152W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.100 7.53E-9 YJL118W YJL118W hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
0.097 1.65E-8 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.094 4.56E-8 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.094 4.60E-8 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division