HIPHOP chemogenomics database
YFL053W / DAK2 
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YFL053W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.100 | 6.20E-9 | YNR029C_p | YNR029C_p | hom | Putative protein of unknown function, deletion confers reduced fitness in saline |
| 0.094 | 4.87E-8 | YGL232W | TAN1 | hom | Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress |
| 0.093 | 5.92E-8 | YAR030C_d | YAR030C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 |
| 0.092 | 1.07E-7 | YBL070C_d | YBL070C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.086 | 6.10E-7 | YDR134C | YDR134C | hom | Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication |
| 0.085 | 8.08E-7 | YDL233W_p | MFG1_p | hom | Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene |
| 0.085 | 9.30E-7 | YGL096W | TOS8 | hom | Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication |
| 0.078 | 5.71E-6 | YOR005C | DNL4 | hom | DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth |
| 0.077 | 7.74E-6 | YIR020C_p | YIR020C_p | hom | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
| 0.077 | 8.00E-6 | YNL198C_d | YNL198C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.076 | 9.28E-6 | YNL209W | SSB2 | hom | Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication |
| 0.075 | 1.23E-5 | YGR132C | PHB1 | hom | Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation |
| 0.075 | 1.34E-5 | YDR314C | RAD34 | hom | Protein involved in nucleotide excision repair (NER); homologous to RAD4 |
| 0.073 | 2.21E-5 | YDL201W | TRM8 | hom | Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p |
| 0.072 | 3.06E-5 | YBR249C | ARO4 | hom | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress |