YFL053W / DAK2

Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL053W / DAK2

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:2.98|P-value:7.27E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.00|P-value:6.64E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.94|P-value:8.33E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.03|P-value:6.07E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.81|P-value:2.32E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.09|P-value:4.72E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:4.05|P-value:7.48E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:5.79|P-value:3.15E-10 ID:SGTC_601|Compound:0986-0029|FD-Score:3.96|P-value:1.15E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.66|P-value:4.56E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:5.85|P-value:1.99E-10 ID:SGTC_716|Compound:1683-5115|FD-Score:3.89|P-value:1.61E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.49|P-value:9.69E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-2.93|P-value:8.79E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.11|P-value:5.74E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.60|P-value:5.88E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:5.09|P-value:2.63E-8 ID:SGTC_979|Compound:1426-2828|FD-Score:2.98|P-value:7.25E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.12|P-value:4.29E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.61|P-value:5.77E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.93|P-value:1.34E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:2.90|P-value:9.89E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.50|P-value:9.05E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.49|P-value:9.74E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.07|P-value:5.13E-4 ID:SGTC_1613|Compound:st002381|FD-Score:5.81|P-value:2.62E-10 ID:SGTC_1619|Compound:st003326|FD-Score:3.96|P-value:1.17E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.02|P-value:6.21E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.90|P-value:9.62E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.09|P-value:4.83E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.82|P-value:2.25E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.67|P-value:4.45E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.36|P-value:1.65E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.09|P-value:4.79E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.71|P-value:3.70E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-2.95|P-value:7.92E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.29|P-value:2.20E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.60|P-value:5.95E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.04|P-value:7.99E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.79|P-value:2.49E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.52|P-value:6.89E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:3.22|P-value:2.90E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:2.94|P-value:8.51E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.26|P-value:2.46E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.94|P-value:1.29E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.85|P-value:1.92E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.10|P-value:4.68E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.56|P-value:7.27E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.65|P-value:4.91E-5 ID:SGTC_3250|Compound:9135583|FD-Score:3.61|P-value:5.80E-5 ID:SGTC_3288|Compound:9119690|FD-Score:2.90|P-value:9.78E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:2.98|P-value:7.27E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.00|P-value:6.64E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.94|P-value:8.33E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.03|P-value:6.07E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.81|P-value:2.32E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.09|P-value:4.72E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:4.05|P-value:7.48E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:5.79|P-value:3.15E-10 ID:SGTC_601|Compound:0986-0029|FD-Score:3.96|P-value:1.15E-5 ID:SGTC_604|Compound:1000-0114|FD-Score:3.66|P-value:4.56E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:5.85|P-value:1.99E-10 ID:SGTC_716|Compound:1683-5115|FD-Score:3.89|P-value:1.61E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.17|P-value:3.49E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.49|P-value:9.69E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:-2.93|P-value:8.79E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.11|P-value:5.74E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.60|P-value:5.88E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:5.09|P-value:2.63E-8 ID:SGTC_979|Compound:1426-2828|FD-Score:2.98|P-value:7.25E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.12|P-value:4.29E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.61|P-value:5.77E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.93|P-value:1.34E-5 ID:SGTC_1149|Compound:3909-7961|FD-Score:2.90|P-value:9.89E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.50|P-value:9.05E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.49|P-value:9.74E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.07|P-value:5.13E-4 ID:SGTC_1613|Compound:st002381|FD-Score:5.81|P-value:2.62E-10 ID:SGTC_1619|Compound:st003326|FD-Score:3.96|P-value:1.17E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.02|P-value:6.21E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.90|P-value:9.62E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.09|P-value:4.83E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.82|P-value:2.25E-5 ID:SGTC_1907|Compound:st060210|FD-Score:3.67|P-value:4.45E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.36|P-value:1.65E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.09|P-value:4.79E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:-3.71|P-value:3.70E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-2.95|P-value:7.92E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.29|P-value:2.20E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.60|P-value:5.95E-5 ID:SGTC_2700|Compound:st077718|FD-Score:4.04|P-value:7.99E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.79|P-value:2.49E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.52|P-value:6.89E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:3.22|P-value:2.90E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:2.94|P-value:8.51E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.26|P-value:2.46E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.94|P-value:1.29E-5 ID:SGTC_2833|Compound:9001315|FD-Score:3.85|P-value:1.92E-5 ID:SGTC_2916|Compound:7875993|FD-Score:3.10|P-value:4.68E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.56|P-value:7.27E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.65|P-value:4.91E-5 ID:SGTC_3250|Compound:9135583|FD-Score:3.61|P-value:5.80E-5 ID:SGTC_3288|Compound:9119690|FD-Score:2.90|P-value:9.78E-4

Top fitness defect scores for YFL053W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_612 0302-0167 5.85 22.4 µM 1.99E-10 copper-dependent oxidative stress 9 2.41E-9
2 SGTC_1613 st002381 5.81 52.1 µM 2.62E-10 5 3.07E-9
3 SGTC_545 4218-0007 5.79 221.0 µM 3.15E-10 7 3.61E-9
4 SGTC_792 4534-1957 5.09 155.0 µM 2.63E-8 16 1.76E-7
5 SGTC_2763 lisinopril 4.52 49.3 µM 6.89E-7 8 3.12E-6
6 SGTC_781 4335-2806 4.11 94.4 µM 5.74E-6 16 2.02E-5
7 SGTC_540 1187-0821 4.05 17.3 µM 7.48E-6 16 2.54E-5
8 SGTC_2700 st077718 4.04 96.8 µM 7.99E-6 13 2.70E-5
9 SGTC_601 0986-0029 3.96 62.9 µM 1.15E-5 calcium & mitochondrial duress 36 3.73E-5
10 SGTC_1619 st003326 3.96 88.7 µM 1.17E-5 60S ribosome export 19 3.77E-5
11 SGTC_2810 7959871 3.94 45.5 µM 1.29E-5 copper-dependent oxidative stress 41 4.11E-5
12 SGTC_1059 3448-6867 3.93 171.0 µM 1.34E-5 11 4.25E-5
13 SGTC_716 1683-5115 3.89 658.0 µM 1.61E-5 21 4.99E-5
14 SGTC_2833 9001315 3.85 45.5 µM 1.92E-5 amide catabolism 59 5.84E-5
15 SGTC_1868 st057644 3.82 42.7 µM 2.25E-5 41 6.70E-5
16 SGTC_274 sirtinol 3.81 40.1 µM 2.32E-5 23 6.88E-5
17 SGTC_1907 st060210 3.67 83.7 µM 4.45E-5 32 1.22E-4
18 SGTC_604 1000-0114 3.66 314.0 µM 4.56E-5 33 1.25E-4
19 SGTC_3048 9093155 3.65 49.5 µM 4.91E-5 9 1.33E-4
20 SGTC_3250 9135583 3.61 49.5 µM 5.80E-5 15 1.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.20E-9 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.094 4.87E-8 YGL232W TAN1 hom Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress
0.093 5.92E-8 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.092 1.07E-7 YBL070C_d YBL070C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.10E-7 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.085 8.08E-7 YDL233W_p MFG1_p hom Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene
0.085 9.30E-7 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.078 5.71E-6 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.077 7.74E-6 YIR020C_p YIR020C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.077 8.00E-6 YNL198C_d YNL198C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.076 9.28E-6 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.075 1.23E-5 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.075 1.34E-5 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.073 2.21E-5 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.072 3.06E-5 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress